Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cleta D'Sa"'
Autor:
John W. Olney, Tatyana Tenkova, Krikor Dikranian, Louis J. Muglia, Walter J. Jermakowicz, Cleta D'Sa, Kevin A. Roth
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 2, Pp 205-219 (2002)
Recently several methods have been described for triggering extensive apoptotic neurodegeneration in the developing in vivo mammalian brain. These methods include treatment with drugs that block NMDA glutamate receptors, drugs that promote GABAA neur
Externí odkaz:
https://doaj.org/article/d8b4c8078c3c4af2818a4f5c9b66c340
Publikováno v:
Cell Death & Differentiation. 9:1063-1068
Bcl-X(L) mice display a similar neurodevelopmental phenotype as rb, DNA ligase IV, and XRCC4 mutant embryos, suggesting that endogenous Bcl-X(L) expression may protect immature neurons from death caused by DNA damage and/or cell cycle dysregulation.
Autor:
Cleta D'Sa, Louis J. Muglia, John W. Olney, Krikor Dikranian, Kevin A. Roth, Walter J. Jermakowicz, Tatyana Tenkova
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 2, Pp 205-219 (2002)
Recently several methods have been described for triggering extensive apoptotic neurodegeneration in the developing in vivo mammalian brain. These methods include treatment with drugs that block NMDA glutamate receptors, drugs that promote GABA(A) ne
Publikováno v:
Oncogene. 20:8281-8286
Neural precursor cells (NPCs) populate the embryonic ventricular zone and persist in the subependymal zone of the adult brain. We hypothesized that hereditary and/or acquired mutations in apoptosis-associated genes, such as p53 and caspases, may prot
Publikováno v:
Developmental Brain Research. 128:187-190
Bid is a BH3 domain only pro-apoptotic member of the Bcl-2 family which interacts with Bax to regulate apoptosis. Bax-deficient embryos show decreased neuronal programmed cell death in vivo and resistance to cytosine arabinoside (AraC)-induced neuron
Autor:
Kevin A. Roth, Cleta D'Sa
Publikováno v:
Mental Retardation and Developmental Disabilities Research Reviews. 7:261-266
Neuronal cell death in the embryonic brain was first recognized almost a century ago. Its significance for normal nervous system development and function has been a major focus of neuroscientific investigation ever since. Remarkable progress has been
Autor:
Cleta D'Sa-Eipper, G. Chinnadurai
Publikováno v:
Oncogene. 16:3105-3114
The human Bfl-1 gene codes for a 175-amino acid BCL-2 family protein that has an anti-apoptosis activity and is overexpressed in certain human epithelial and hematopoietic malignancies. Bfl-1 efficiently suppresses apoptosis induced by the p53 tumor
Autor:
Cleta D'Sa-Eipper, Thirugnana Subramanian, L.K. Venkatesh, B Elangovan, G. Chinnadurai, Janice M. Boyd, Ute Schaeper, Scott Malstrom
Publikováno v:
Cell. 79:341-351
Adenovirus E1B 19 kDa protein protects against cell death induced by viral infection and certain external stimuli. The Bcl-2 protein can functionally substitute for the E1B 19 kDa protein. To identify cellular targets for the 19 kDa protein, we used
Autor:
Tulia Lindsten, Kevin A. Roth, Francesco Cecconi, Barbara J. Klocke, Cleta D'Sa, Stanley J. Korsmeyer, Craig B. Thompson, Richard A. Flavell
Publikováno v:
Journal of neuroscience research. 74(3)
Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain. We have shown previously that the apoptotic
Publikováno v:
Journal of neuropathology and experimental neurology. 61(8)
Targeted gene disruptions have revealed significant roles for caspase family members in the regulation of neuronal programmed cell death. Both caspase-3- and caspase-9-deficient mice exhibit a variably severe neurodevelopmental phenotype that may inc