Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Cleo J. C. Connolly"'
Autor:
Jack J. Kinsora, Jared B.J. Milbank, Rachel M. Brooker, Christopher S. Knauer, Kenneth S. Kilgore, Cleo J. C. Connolly, John A. Wendt, Corinne E. Augelli-Szafran, Koji Yamagata, Susan E. Bove, Mickelson John, Paul Galatsis, Roy D. Schwarz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6525-6528
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99bb1ead705ce7ec70a6e5c13920183
https://doi.org/10.1016/j.bmcl.2007.09.083
https://doi.org/10.1016/j.bmcl.2007.09.083
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8a8aa89569f777c79f4224db99ed
https://doi.org/10.1016/j.bmcl.2007.05.083
https://doi.org/10.1016/j.bmcl.2007.05.083
Autor:
Alan J. Kraker, William L. Elliott, Sheila M. Crean, Tawny K. Dahring, Charles W. Moore, Patrick J. Grohar, Cleo J. C. Connolly, Mark R. Barvian, Gina Lu, H. D. Hollis Showalter, Patrick Vincent, Terry C. Major, and Annette M. Doherty, Robert L. Panek, Denise L. Driscoll, James M. Hamby, Mel C. Schroeder, Stacey L. Boushelle, Brian L. Batley, R. Thomas Winters
Publikováno v:
Journal of medicinal chemistry. 44(12)
In continuing our search for medicinal agents to treat proliferative diseases, we have discovered 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas as a novel class of soluble, potent, broadly active tyrosine kinase (TK) inhibitors. An efficient r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404cfa4f92f436aa35b392e52070e9a2
https://pubmed.ncbi.nlm.nih.gov/11384237
https://pubmed.ncbi.nlm.nih.gov/11384237