Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Cleo, Kontoravdi"'
Autor:
Konstantinos Flevaris, Joseph Davies, Shoh Nakai, Frano Vučković, Gordan Lauc, Malcolm G. Dunlop, Cleo Kontoravdi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1234-1243 (2024)
Effective management of chronic diseases and cancer can greatly benefit from disease-specific biomarkers that enable informative screening and timely diagnosis. IgG N-glycans found in human plasma have the potential to be minimally invasive disease-s
Externí odkaz:
https://doaj.org/article/72332fe12d9c4affa08d4777944d1896
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3639-3655 (2023)
Mammalian cells produce up to 80 % of the commercially available therapeutic proteins, with Chinese Hamster Ovary (CHO) cells being the primary production host. Manufacturing involves a train of reactors, the last of which is typically run in fed-bat
Externí odkaz:
https://doaj.org/article/c65e841a9026490c8b1353f955eb166e
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1543-1549 (2023)
With the plethora of omics data becoming available for mammalian cell and, increasingly, human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful tool for their organisation and analysis. The systems biology community has dev
Externí odkaz:
https://doaj.org/article/3f7b863c96e24bb7b883128ca9c43006
Publikováno v:
International Journal of Technology, Vol 13, Iss 8, Pp 1630-1639 (2022)
The need to increase the COVID-19 vaccine manufacturing capacity at low to middle-income countries (LMIC) led to a growing focus on Novavax (NVX-CoV2373), a thermostable protein subunit vaccine manufactured using a baculovirus and insect cell syst
Externí odkaz:
https://doaj.org/article/35265d2e8bf640d69fc737e18ae26548
Autor:
Dauda Ibrahim, Zoltán Kis, Maria M. Papathanasiou, Cleo Kontoravdi, Benoît Chachuat, Nilay Shah
Publikováno v:
Vaccines, Vol 12, Iss 2, p 158 (2024)
The simultaneous administration of SARS-CoV-2 and influenza vaccines is being carried out for the first time in the UK and around the globe in order to mitigate the health, economic, and societal impacts of these respiratory tract diseases. However,
Externí odkaz:
https://doaj.org/article/f8bb2990b3454db2a84d949ad010a983
Autor:
Zoltán Kis, Kyungjae Tak, Dauda Ibrahim, Maria M. Papathanasiou, Benoît Chachuat, Nilay Shah, Cleo Kontoravdi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Rapid global COVID-19 pandemic response by mass vaccination is currently limited by the rate of vaccine manufacturing. This study presents a techno-economic feasibility assessment and comparison of three vaccine production platform technolog
Externí odkaz:
https://doaj.org/article/e1b37826b3134561808f377e5c002226
Autor:
Damien van de Berg, Zoltán Kis, Carl Fredrik Behmer, Karnyart Samnuan, Anna K. Blakney, Cleo Kontoravdi, Robin Shattock, Nilay Shah
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Rapid-response vaccine production platform technologies, including RNA vaccines, are being developed to combat viral epidemics and pandemics. A key enabler of rapid response is having quality-oriented disease-agnostic manufacturing protocols
Externí odkaz:
https://doaj.org/article/07c8cff71bf445a6a6254505e668c398
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3287-3300 (2020)
With omics data being generated at an unprecedented rate, genome-scale modelling has become pivotal in its organisation and analysis. However, machine learning methods have been gaining ground in cases where knowledge is insufficient to represent the
Externí odkaz:
https://doaj.org/article/4189688ff16a4a0da3323dbea16a5dde
Autor:
Sakhr Alhuthali, Cleo Kontoravdi
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265886 (2022)
Monoclonal antibodies (mAbs) have been extensively studied for their wide therapeutic and research applications. Increases in mAb titre has been achieved mainly by cell culture media/feed improvement and cell line engineering to increase cell density
Externí odkaz:
https://doaj.org/article/42fa65078fb54df9973e44c77e2aae99
Autor:
Elena Palmieri, Zoltán Kis, James Ozanne, Roberta Di Benedetto, Beatrice Ricchetti, Luisa Massai, Martina Carducci, Davide Oldrini, Gianmarco Gasperini, Maria Grazia Aruta, Omar Rossi, Cleo Kontoravdi, Nilay Shah, Fatme Mawas, Francesca Micoli
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1034 (2022)
Group A Streptococcus (GAS) causes about 500,000 annual deaths globally, and no vaccines are currently available. The Group A Carbohydrate (GAC), conserved across all GAS serotypes, conjugated to an appropriate carrier protein, represents a promising
Externí odkaz:
https://doaj.org/article/51ad062515b741b4afe2d444e2ee2b4a