Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug‐resistant chronic lymphocytic leukemia

Autor: Fotini Kostopoulou, Clementine Gabillaud, Elise Chapiro, Beatrice Grange, Julie Tran, Simon Bouzy, Michael Degaud, Hussein Ghamlouch, Magali Le Garff‐Tavernier, Karim Maloum, Sylvain Choquet, Veronique Leblond, Jean Gabarre, Anne Lavaud, Veronique Morel, Damien Roos‐Weil, Madalina Uzunov, Romain Guieze, Olivier A. Bernard, Santos A. Susin, Olivier Tournilhac, Florence Nguyen‐Khac, the French Innovative Leukemia Organization (FILO) group

Publikováno v: Cancer Medicine, Vol 8, Iss 6, Pp 3131-3141 (2019)

Abstract The different types of drug resistance encountered in chronic lymphocytic leukemia (CLL) cannot be fully accounted for by the 17p deletion (and/or TP53 mutation), a complex karyotype (CK), immunoglobulin heavy‐chain variable region genes (

Externí odkaz: https://doaj.org/article/7d10de105bfe4bc180f4ac188592025d

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Autor: Olivier A. Bernard, Elodie Pramil, Florence Nguyen-Khac, Clementine Gabillaud, Nathalie Nadal, Elise Chapiro, Simon Bouzy, Frederic Davi, Stéphanie Struski, Damien Roos-Weil, Christine Lefebvre, Evelyne Callet-Bauchu, Magali Le Garff-Tavernier, Philippe Dessen, Virginie Eclache, Caroline Algrin, Jean-François Lesesve, Veronique Leblond, Lena Wagner, Claude Lesty, Sandra Fert-Ferrer, Melanie Yon, Ludovic Jondreville, Nathalie Auger, Jean Gabarre, Antoine Ittel, Marie-Agnès Collonge-Rame, Karim Maloum, Clémentine Dillard, M'Boyba Diop, Catherine Settegrana, Thorsten Zenz, Sebastian Scheinost, Baptiste Gaillard, Benoit Quilichini, Isabelle Radford-Weiss, Marc Muller, Nathalie Droin, Lucile Baseggio, Santos A. Susin

Publikováno v: Blood
Blood, American Society of Hematology, 2019, ⟨10.1182/blood.2019001187⟩
Blood, American Society of Hematology, 2019, 134 (21), pp.1821-1831. ⟨10.1182/blood.2019001187⟩

International audience; B-cell prolymphocytic leukemia (B-PLL) is a rare hematological disorder whose underlying oncogenic mechanisms are poorly understood. Our cytogenetic and molecular assessment of 34 patients with B-PLL revealed several disease-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0565b574ce8aff76aa9fc048905b2f
https://hal.sorbonne-universite.fr/hal-02363995/document

Genetic Characterization of B-Cell Prolymphocytic Leukemia (B-PLL): A Hierarchical Prognostic Model Involving MYC and TP53 Abnormalities. on Behalf of the Groupe Francophone De Cytogenetique Hematologique (GFCH) and the French Innovative Leukemia Organization (FILO) Group

Autor: Sandra Fert-Ferrer, Baptiste Gaillard, Nathalie Droin, Lena Wagner, Philippe Dessen, Antoine Ittel, Evelyne Callet-Bauchu, Catherine Settegrana, Benoit Quilichini, Nathalie Auger, Virginie Eclache, Melanie Yon, Nadia Bougacha, Karim Maloum, Florence Nguyen-Khac, Elodie Pramil, Elise Chapiro, Christine Lefebvre, Clementine Gabillaud, Nathalie Nadal, Claude Lesty, Frederic Davi, Simon Bouzy, Stéphanie Struski, Damien Roos-Weil, Olivier A. Bernard, Clémentine Dillard, Thorsten Zenz, Santos A. Susin, Marie-Agnès Collonge-Rame, Magali Le Garff-Tavernier, Caroline Algrin, Sebastian Scheinost, M'Boyba Diop, Lucile Baseggio, Isabelle Radford-Weiss, Marc Muller, Véronique Leblond

Publikováno v: Blood. 132:943-943

B-PLL is defined by the presence of prolymphocytes in peripheral blood exceeding 55% of lymphoid cells. The diagnosis, mainly based on clinical and morphological data, can be difficult because of overlap with other B-cell malignancies. Because of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c466a523576a67afb285bde1ab6761c8
https://doi.org/10.1182/blood-2018-99-115085

The Gain of the Short Arm of Chromosome 2 (2p+) Induces XPO1 Overexpression and Drug Resistance in Chronic Lymphocytic Leukemia

Autor: Karim Maloum, Caroline Algrin, Stéphane Leprêtre, Clementine Gabillaud, Julie Lejeune, Laurent Sutton, Véronique Leblond, Frederic Davi, Claude Lesty, Elise Chapiro, Frederik Damm, H. Merle-Beral, Madalina Uzunov, Florence Nguyen-Khac, Sylvain Choquet, Pierre Feugier, Véronique Morel, Jérôme Lambert, Hong-Anh Cung, Santos A. Susin, Adrien Cosson

Publikováno v: Blood. 126:492-492

Introduction: CLL is a heterogeneous disease in terms of response to treatment, with some patients reaching complete and prolonged remissions, while others relapsing early and requiring several lines of treatments. This highly variable course is part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90f9f53618500e9c5881d6d1332e4685
https://doi.org/10.1182/blood.v126.23.492.492