Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption

Autor: Napimoga, MH, Rocha, EP, Trindade-da-Silva, CA, Demasi, APD, Martinez, EF, Macedo, CG, Abdalla, HB, Bettaieb, A, Haj, FG, Clemente-Napimoga, JT, Inceoglu, B, Hammock, BD

Publikováno v: Journal of periodontal research, vol 53, iss 5

BACKGROUND AND OBJECTIVE:Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::254d9068643070ebc44a3451911b0c01
https://escholarship.org/uc/item/91z5h1xn

Novel apocynin regulates TRPV1 activity in the trigeminal system and controls pain in a temporomandibular joint neurogenic model.

Autor: Machado TMMM; Faculdade São Leopoldo Mandic, Campinas, SP, Brazil., Aquino IG; Faculdade São Leopoldo Mandic, Campinas, SP, Brazil., Franchin M; School of Dentistry, Federal University of Alfenas (Unifal-MG), Alfenas, MG, Brazil; Bioactivity and Applications Lab, Department of Biological Sciences, Faculty of Science and Engineering, School of Natural Sciences, University of Limerick, Limerick, Ireland., Zarraga MO; Department of Organic Chemistry, Faculty of Chemical Sciences, Universidad de Concepcion, Concepcion, Chile., Bustos D; Centro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca, Chile; Laboratorio de Bioinformática y Química Computacional (LBQC), Escuela de Bioingeniería Médica, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile., Spada FP; Department of Agri-Food Industry, Food, and Nutrition, Luiz de Queiroz College of Agriculture, University of São Paulo (USP), Piracicaba, SP, Brazil., Napimoga MH; Faculdade São Leopoldo Mandic, Campinas, SP, Brazil., Clemente-Napimoga JT; Faculdade São Leopoldo Mandic, Campinas, SP, Brazil., Alencar SM; Department of Agri-Food Industry, Food, and Nutrition, Luiz de Queiroz College of Agriculture, University of São Paulo (USP), Piracicaba, SP, Brazil., Benso B; School of Dentistry, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. Electronic address: bruna.benso@uc.cl., Abdalla HB; Faculdade São Leopoldo Mandic, Campinas, SP, Brazil. Electronic address: henrique.abdalla@slmandic.edu.br.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Nov 01; Vol. 985, pp. 177093. Date of Electronic Publication: 2024 Nov 01.

Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor.

Autor: Trindade-da-Silva CA; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil; Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA., Yang J; Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA; EicOsis LLC, Davis, CA, USA., Fonseca F; Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA., Pham H; Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA., Napimoga MH; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil., Abdalla HB; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil., Aver G; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil., De Oliveira MJA; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil., Hammock BD; Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA; EicOsis LLC, Davis, CA, USA., Clemente-Napimoga JT; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, Brazil. Electronic address: juliana.napimoga@slmandic.edu.br.

Publikováno v: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2024 Mar; Vol. 1869 (2), pp. 159432. Date of Electronic Publication: 2023 Nov 19.

Sema4D is diminished in leukocyte platelet-rich fibrin and impairs pre-osteoblastic MC3T3-E1 cells' functionality.

Autor: Smanio Neto H; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Implantology, Campinas, SP, Brazil., Moy PK; UCLA, Department of Oral & Maxillofacial Surgery, Los Angeles, CA, USA., Martinez EF; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Oral Pathology and Cell Biology, Campinas, SP, Brazil., Pelegrine AA; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Implantology, Campinas, SP, Brazil., Abdalla HB; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Neuroimmune Interface of Pain Research Lab, Campinas, SP, Brazil., Clemente-Napimoga JT; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Neuroimmune Interface of Pain Research Lab, Campinas, SP, Brazil., Napimoga MH; Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Neuroimmune Interface of Pain Research Lab, Campinas, SP, Brazil. Electronic address: marcelo.napimoga@slmandic.edu.br.

Publikováno v: Archives of oral biology [Arch Oral Biol] 2023 Nov; Vol. 155, pp. 105778. Date of Electronic Publication: 2023 Jul 29.

Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity.

Autor: Abdalla HB; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA.; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil., Alvarez C; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA., Wu YC; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA.; Harvard School of Dental Medicine, Boston, Massachusetts, USA., Rojas P; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA., Hammock BD; Department of Entomology and UCD Comprehensive Cancer Center, University of California, Davis, California, USA., Maddipati KR; Department of Pathology, Wayne State University, Detroit, Michigan, USA., Trindade-da-Silva CA; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil., Soares MQS; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil., Clemente-Napimoga JT; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil., Kantarci A; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA., Napimoga MH; Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil., Van Dyke TE; Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts, USA.; Department of Oral Medicine, Infection, and Immunity, Faculty of Medicine, Harvard University, Boston, Massachusetts, USA.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2023 Jun; Vol. 180 (12), pp. 1597-1615. Date of Electronic Publication: 2023 Jan 30.