Zobrazeno 1 - 10
of 473
pro vyhledávání: '"Clemente Capasso"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
This study refers to the intricate world of Acinetobacter baumannii, a resilient pathogenic bacterium notorious for its propensity at antibiotic resistance in nosocomial infections. Expanding upon previous findings that emphasised the bifunctional en
Externí odkaz:
https://doaj.org/article/2695134eb484442e93e679573d836733
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Toxoplasmosis, induced by the intracellular parasite Toxoplasma gondii, holds considerable implications for global health. While treatment options primarily focusing on folate pathway enzymes have notable limitations, current research endeavours conc
Externí odkaz:
https://doaj.org/article/f91536a23fc84dd687c7b04590f9c026
Autor:
Alessandro Bonardi, Alessio Nocentini, Viviana de Luca, Clemente Capasso, Eslam B. Elkaeed, Wagdy M. Eldehna, Claudiu T. Supuran
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10006 (2024)
This study proposes a novel therapeutic strategy for cancer management by combining the antitumor effects of hydrogen sulfide (H2S) and inhibition of carbonic anhydrases (CAs; EC 4.2.1.1), specifically isoforms IV, IX, and XII. H2S has demonstrated c
Externí odkaz:
https://doaj.org/article/d5b33b5349d549c3826178c32030e9d2
Autor:
Letizia Giampietro, Beatrice Marinacci, Alice Della Valle, Ilaria D’Agostino, Aldo Lauro, Mattia Mori, Simone Carradori, Alessandra Ammazzalorso, Barbara De Filippis, Cristina Maccallini, Andrea Angeli, Clemente Capasso, Santolo Francati, Adriano Mollica, Rossella Grande, Claudiu T. Supuran
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1027 (2024)
Research into novel anti-Helicobacter pylori agents represents an important approach for the identification of new treatments for chronic gastritis and peptic ulcers, which are associated with a high risk of developing gastric carcinoma. In this resp
Externí odkaz:
https://doaj.org/article/e8bcd8f3bb00451a977dcf04b8008312
Autor:
Marialuigia Fantacuzzi, Ilaria D’Agostino, Simone Carradori, Francesco Liguori, Fabrizio Carta, Mariangela Agamennone, Andrea Angeli, Filomena Sannio, Jean-Denis Docquier, Clemente Capasso, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Vibrio cholerae causes life-threatening infections in low-income countries due to the rise of antibacterial resistance. Innovative pharmacological targets have been investigated and carbonic anhydrases (CAs, EC: 4.2.1.1) encoded by V. cholerae (VchCA
Externí odkaz:
https://doaj.org/article/2b2ee7385c74438ea7ee86320973175f
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The γ-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium, Mammaliicoccus (Staphylococcus) sciuri (MscCAγ) was recently cloned and purified by our groups. Here we investigated inhibition of this enzyme with (in)organic simple and comp
Externí odkaz:
https://doaj.org/article/37083c9acd3742bf945bb361909dda21
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and
Externí odkaz:
https://doaj.org/article/78761aff2ac64346a46d67d671031268
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2092-2098 (2022)
Carbonic anhydrases, catalysing the reversible CO2 hydration reaction, contribute in all living organisms to the maintenance of stable metabolic functions depending on intracellular concentrations of carbon dioxide, bicarbonate, and protons. Recent s
Externí odkaz:
https://doaj.org/article/c24a82beb06d4e3fbdd07d88c98bb8a8
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2786-2792 (2022)
A β-carbonic anhydrase (CA, EC 4.2.1.1) previously annotated to be present in the genome of Staphylococcus aureus, SauBCA, has been shown to belong to another pathogenic bacterium, Mammaliicoccus (Staphylococcus) sciuri. This enzyme, MscCA, has been
Externí odkaz:
https://doaj.org/article/e18514fffad44559bc26538e46288bea
Autor:
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 333-338 (2022)
Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs. Here we demonstrate that such enzymes from the bacterial pathogens Neiss
Externí odkaz:
https://doaj.org/article/28b2248586f446c9ba2b17701ba77732