Zobrazeno 1 - 10 of 120 pro vyhledávání: '"Clement T Loy"'
1
Akademický článek
C9ORF72 repeat expansion in Australian and Spanish frontotemporal dementia patients.
Autor: Carol Dobson-Stone, Marianne Hallupp, Clement T Loy, Elizabeth M Thompson, Eric Haan, Carolyn M Sue, Peter K Panegyres, Cristina Razquin, Manuel Seijo-Martínez, Ramon Rene, Jordi Gascon, Jaume Campdelacreu, Birgit Schmoll, Alexander E Volk, William S Brooks, Peter R Schofield, Pau Pastor, John B J Kwok
Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56899 (2013)
A hexanucleotide repeat expansion in C9ORF72 has been established as a common cause of frontotemporal dementia (FTD). However, the minimum repeat number necessary for disease pathogenesis is not known. The aims of our study were to determine the freq
Externí odkaz: https://doaj.org/article/34d9fa3edd3248f2999405cb91c6ba3c
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2
Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates
Autor: Michael H, Connors, Armando, Teixeira-Pinto, Clement T, Loy
Publikováno v: The Journal of Neuropsychiatry and Clinical Neurosciences. 35:69-76
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease resulting in motor disturbances, dementia, and psychiatric symptoms. Apathy is a common manifestation and rated as one of the most impactful by patients and caregivers. It c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edee86ef66a557b60d6ff43f6e6b7ad1
https://doi.org/10.1176/appi.neuropsych.21070191
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3
Akademický článek
The complex relationship between genotype, pathology and phenotype in familial dementia
Autor: John B. Kwok, Clement T. Loy, Carol Dobson-Stone, Glenda M. Halliday
Publikováno v: Neurobiology of Disease, Vol 145, Iss , Pp 105082- (2020)
Causative genes involved in familial forms of dementias, including Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) and dementia with Lewy bodies (DLB), as well as amyotrophic lateral sclerosis and prion diseases where dementia is p
Externí odkaz: https://doaj.org/article/11491c70bdf2446ea0ead6b42af55778
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7
Data from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Autor: Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microsco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458dcb870e35eaa46251de3f99e9798
https://doi.org/10.1158/1535-7163.c.6531162
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10
Akademický článek
Huntington Disease: The Complexities of Making and Disclosing a Clinical Diagnosis After Premanifest Genetic Testing
Autor: Elizabeth A. McCusker, Clement T. Loy
Publikováno v: Tremor and Other Hyperkinetic Movements, Vol 7 (2017)
The management of patients and families affected by Huntington disease (HD) is complicated by several factors, both practical and ethical. It can be difficult to determine the onset of clinically manifest HD (mHD). In addition, it can be challenging
Externí odkaz: https://doaj.org/article/84ee773a9b8f41b380900f9d654b2b70
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