Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Clement T, Loy"'
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105082- (2020)
Causative genes involved in familial forms of dementias, including Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) and dementia with Lewy bodies (DLB), as well as amyotrophic lateral sclerosis and prion diseases where dementia is p
Externí odkaz:
https://doaj.org/article/11491c70bdf2446ea0ead6b42af55778
Publikováno v:
The Journal of Neuropsychiatry and Clinical Neurosciences. 35:69-76
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease resulting in motor disturbances, dementia, and psychiatric symptoms. Apathy is a common manifestation and rated as one of the most impactful by patients and caregivers. It c
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. S1 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0595d9ccc193c5c4dd6436ba0d3685f7
https://doi.org/10.1158/1535-7163.22483554
https://doi.org/10.1158/1535-7163.22483554
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Methods from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4016373736a2af88b93a483de1380
https://doi.org/10.1158/1535-7163.22483524
https://doi.org/10.1158/1535-7163.22483524
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Table S3 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4404bcc724ec46d0dc423beee96d7d8a
https://doi.org/10.1158/1535-7163.22483515
https://doi.org/10.1158/1535-7163.22483515
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458dcb870e35eaa46251de3f99e9798
https://doi.org/10.1158/1535-7163.c.6531162
https://doi.org/10.1158/1535-7163.c.6531162
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b3ed18a9fbe5dab79cee17aedfa7a
https://doi.org/10.1158/1535-7163.22483527.v1
https://doi.org/10.1158/1535-7163.22483527.v1
Autor:
Elizabeth A. McCusker, Clement T. Loy
Publikováno v:
Neurology. 100:993-994
Autor:
Elizabeth A. McCusker, Clement T. Loy
Publikováno v:
Tremor and Other Hyperkinetic Movements, Vol 7 (2017)
The management of patients and families affected by Huntington disease (HD) is complicated by several factors, both practical and ethical. It can be difficult to determine the onset of clinically manifest HD (mHD). In addition, it can be challenging
Externí odkaz:
https://doaj.org/article/84ee773a9b8f41b380900f9d654b2b70
Autor:
Wei Yin Lim, Clement T. Loy, Stephanie A Ward, Carole Parsons, Bernadette McGuinness, Carmel Hughes, Peter Passmore
Publikováno v:
Cochrane Database Syst Rev
Parsons, C, Ward, S, McGuinness, B, Passmore, P, Hughes, C, Loy, C & Lim, W Y 2021, ' Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia ', Cochrane database of systematic reviews (Online), vol. 2021, no. 1, CD009081 . https://doi.org/10.1002/14651858.CD009081.pub2
Parsons, C, Ward, S, McGuinness, B, Passmore, P, Hughes, C, Loy, C & Lim, W Y 2021, ' Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia ', Cochrane database of systematic reviews (Online), vol. 2021, no. 1, CD009081 . https://doi.org/10.1002/14651858.CD009081.pub2
Background:Dementia is a progressive syndrome characterised by deterioration in memory, thinking and behaviour, and by impaired ability to perform daily activities. Two classes of drug ‐ cholinesterase inhibitors (donepezil, galantamine and rivasti