Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Clement Oyeniran"'
Autor:
Christopher D. Green, Cynthia Weigel, Clement Oyeniran, Briana N. James, Deanna Davis, Usha Mahawar, Jason Newton, Binks W. Wattenberg, Michael Maceyka, Sarah Spiegel
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100082- (2021)
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT. However, the roles of in
Externí odkaz:
https://doaj.org/article/0535935790a34defb008a718f697ca20
Autor:
Lin Cai, Clement Oyeniran, Debolina D. Biswas, Jeremy Allegood, Sheldon Milstien, Tomasz Kordula, Michael Maceyka, Sarah Spiegel
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1412-1422 (2016)
The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Although much has been learned about ceramide generation by ac
Externí odkaz:
https://doaj.org/article/b5476c5c1ae144bca1ac9d9ca819d272
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Supplementary Table from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032a5df391d5f4fa05c5afc7f2e1db25
https://doi.org/10.1158/2159-8290.22541404.v1
https://doi.org/10.1158/2159-8290.22541404.v1
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7aff3a4b13eb09415758e2513af039
https://doi.org/10.1158/2159-8290.c.6549634.v1
https://doi.org/10.1158/2159-8290.c.6549634.v1
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Supplementary Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01500e10207400a070376439f471923d
https://doi.org/10.1158/2159-8290.22541428.v1
https://doi.org/10.1158/2159-8290.22541428.v1
Autor:
Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird
Publikováno v:
Cancer Discovery
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179
Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a6f369ad5cbcb85ed2d339d7aa9050
https://cnrs.hal.science/hal-03759864/document
https://cnrs.hal.science/hal-03759864/document
Autor:
Alexandre G. Casanova, Li-Sheng Zhang, Ning Tsao, Brittany A. Townley, Nima Mosammaparast, Joshua R. Brickner, Chuan He, John A. Tainer, Rebecca Rodell, Tanveer Ahmad, Matthew D. Wood, Hua Sun, Jennifer M. Soll, Nicolas Reynoird, Clement Oyeniran, Alessandro Vindigni, Adit Ganguly, Albino Bacolla, Valentina Lukinović
Publikováno v:
Mol Cell
Molecular Cell
Molecular Cell, 2021, 81 (20), pp.4228-4242.e8. ⟨10.1016/j.molcel.2021.09.024⟩
Molecular Cell
Molecular Cell, 2021, 81 (20), pp.4228-4242.e8. ⟨10.1016/j.molcel.2021.09.024⟩
International audience; Summary Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the activation of the ASCC-ALKBH3 repair pathway is exquisitely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22341f9c122e9653e82bea7080278c0
https://europepmc.org/articles/PMC8931856/
https://europepmc.org/articles/PMC8931856/
Autor:
Rebecca Rodell, Nima Mosammaparast, Ning Tsao, Nicolas Reynoird, Li-Sheng Zhang, Alexandre G. Casanova, Valentina Lukinović, Joshua R. Brickner, Jennifer M. Soll, Adit Ganguly, Chuan He, Clement Oyeniran, John A. Tainer, Albino Bacolla
SummaryA critical question in genome stability is the nature of the chemical damage responsible for repair activation. We previously reported a novel pathway specifically activated during alkylation damage in human cells, where the E3 ubiquitin ligas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867951cfd90be837ec436deaf9848cf3
https://doi.org/10.1101/2020.08.28.271874
https://doi.org/10.1101/2020.08.28.271874
Autor:
Elisa N.D. Palladino, Cynthia Weigel, Rebecca K. Martin, Joan M. Cook-Mills, Jason Newton, Melissa A. Maczis, Briana N. James, Sally E. Wenzel, Sarah Spiegel, Joseph C. Lownik, Clement Oyeniran, Jamie Sturgill, Sheldon Milstien, Erhard Bieberich, John B. Trudeau
Publikováno v:
J Allergy Clin Immunol
Background Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity. Objective We sought to investigate the functional role of ceramide in mouse models of allergic airwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0161d35ba7204b7db26838b37071320
https://pubmed.ncbi.nlm.nih.gov/33130063
https://pubmed.ncbi.nlm.nih.gov/33130063
Autor:
Michael Field, Patrick M. Lombardi, Renana Rabe, Clement Oyeniran, Jozef Gecz, Jessica Jackson, Yu Zhao, Cathrine Broberg Vågbø, Geir Slupphaug, Meagan E Sullender, Cynthia Wolberger, Joshua R. Brickner, Jennifer M. Soll, Alessandro Vindigni, Elyse M Blazosky, Nima Mosammaparast, Mark A. Corbett, Andrea K. Byrum, Miranda C. Mudge
Publikováno v:
Nature
DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms for repairing several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b972036f271efca708c243af065814
https://doi.org/10.1038/nature24484
https://doi.org/10.1038/nature24484