Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Clemens Neufert"'
Autor:
Lars Tögel, Christoph Schubart, Sebastian Lettmaier, Clemens Neufert, Juliane Hoyer, Kerstin Wolff, Evgeny A Moskalev, Robert Stöhr, Abbas Agaimy, André Reis, Bernd Wullich, Andreas Mackensen, Marianne Pavel, Matthias W. Beckmann, Arndt Hartmann, Rainer Fietkau, Norbert Meidenbauer, Florian Haller, Silvia Spoerl
Publikováno v:
Cancers, Vol 15, Iss 24, p 5892 (2023)
Molecular Tumor Boards (MTBs) converge state-of-the-art next-generation sequencing (NGS) methods with the expertise of an interdisciplinary team consisting of clinicians, pathologists, human geneticists, and molecular biologists to provide molecularl
Externí odkaz:
https://doaj.org/article/1d75561ad9fa43f882a8b40ebf6ca511
Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease
Autor:
Diana M. Matthe, Martin Dinkel, Benjamin Schmid, Tina Vogler, Markus F. Neurath, Hendrik Poeck, Clemens Neufert, Maike Büttner-Herold, Kai Hildner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Acute graft-versus-host disease (GvHD) remains the biggest clinical challenge and prognosis-determining complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor T cells are acceptedly key mediators of alloreactivity ag
Externí odkaz:
https://doaj.org/article/98fe6b006d434d23960a867290ab3beb
Autor:
Aylin Lindemann, Dominik Roth, Kristina Koop, Clemens Neufert, Sebastian Zundler, Raja Atreya, Markus F. Neurath, Moritz Leppkes
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Background and aimsAcute severe steroid-refractory ulcerative colitis remains a medically challenging condition with frequent need of surgery. It can be treated with the calcineurin inhibitor cyclosporine A with the need for therapeutic drug monitori
Externí odkaz:
https://doaj.org/article/1cd45e5b0692471ea658653720605cdf
Autor:
Kristina Koop, Karin Enderle, Miriam Hillmann, Laura Ruspeckhofer, Michael Vieth, Gregor Sturm, Zlatko Trajanoski, Anja A. Kühl, Raja Atreya, Moritz Leppkes, Patrick Baum, Janine Roy, Andrea Martin, Markus F. Neurath, Clemens Neufert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundFibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall. The prevention and medical therapy of fibrostenotic CD is an unmet hi
Externí odkaz:
https://doaj.org/article/08cb77265210420bb89b921f76e186fd
Autor:
Martin Hohmann, Ingo Ganzleben, Alexander Grünberg, Jean Gonzales-Menezes, Florian Klämpfl, Benjamin Lengenfelder, Eva Liebing, Christina Heichler, Clemens Neufert, Christoph Becker, Markus F. Neurath, Maximilian J. Waldner, Michael Schmidt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Multi- and hyperspectral endoscopy are possibilities to improve the endoscopic detection of neoplastic lesions in the colon and rectum during colonoscopy. However, most studies in this context are performed on histological samples/biopsies o
Externí odkaz:
https://doaj.org/article/2a757e5b06084b588f75b502956d295e
Autor:
Christina Heichler, Anabel Schmied, Karin Enderle, Kristina Scheibe, Marta Murawska, Benjamin Schmid, Maximilian J. Waldner, Markus F. Neurath, Clemens Neufert
Publikováno v:
Cancers, Vol 14, Iss 6, p 1472 (2022)
Colorectal cancer (CRC) is a common disease and has limited treatment options. The importance of cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in CRC has been increasingly recognized. However, the role of CAF subsets in
Externí odkaz:
https://doaj.org/article/1b1c235652c749b6b786df365ada76d1
Autor:
Vera Buchele, Patrick Konein, Tina Vogler, Timo Kunert, Karin Enderle, Hanif Khan, Maike Büttner-Herold, Christian H. K. Lehmann, Lukas Amon, Stefan Wirtz, Diana Dudziak, Markus F. Neurath, Clemens Neufert, Kai Hildner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Inflammatory bowel diseases (IBDs) are characterized by chronic, inflammatory gastrointestinal lesions and often require life-long treatment with immunosuppressants and repetitive surgical interventions. Despite progress in respect to the characteriz
Externí odkaz:
https://doaj.org/article/b8126bfbdeea4bca8113f41e9fa8090c
Autor:
Anja Schulz-Kuhnt, Vicky Greif, Kai Hildner, Lisa Knipfer, Michael Döbrönti, Sabine Zirlik, Florian Fuchs, Raja Atreya, Sebastian Zundler, Rocío López-Posadas, Clemens Neufert, Andreas Ramming, Alexander Kiefer, Anika Grüneboom, Erwin Strasser, Stefan Wirtz, Markus F. Neurath, Imke Atreya
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymphoid cells
Externí odkaz:
https://doaj.org/article/b9a2b170082845fa8e41cb11a39c42f7
Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration
Autor:
Karin Enderle, Martin Dinkel, Eva-Maria Spath, Benjamin Schmid, Sebastian Zundler, Philipp Tripal, Markus F. Neurath, Kai Hildner, Clemens Neufert
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5148 (2021)
Intraepithelial lymphocytes (IEL) are widely distributed within the small intestinal epithelial cell (IEC) layer and represent one of the largest T cell pools of the body. While implicated in the pathogenesis of intestinal inflammation, detailed insi
Externí odkaz:
https://doaj.org/article/afc830e9c88042298bb0cae49d0e8bda
Autor:
Charlotte Lichnog, Sha Klabunde, Emily Becker, Franklin Fuh, Philipp Tripal, Raja Atreya, Entcho Klenske, Rich Erickson, Henry Chiu, Chae Reed, Shan Chung, Clemens Neufert, Imke Atreya, Jacqueline McBride, Markus F. Neurath, Sebastian Zundler
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: Anti-integrin therapy is a new frontline strategy in the treatment of inflammatory bowel diseases (IBD). The anti-β7 integrin antibody etrolizumab is currently being investigated for safety and efficacy in Crohn’s disease (CD) and ulce
Externí odkaz:
https://doaj.org/article/f1a7cedb62f746388bc1be550968ff7b