Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Clemens Löwik"'
Autor:
Natasa Gaspar, Maryana Handula, Marcus C. M. Stroet, Kranthi Marella-Panth, Joost Haeck, Thomas A. Kirkland, Mary P. Hall, Lance P. Encell, Simone Dalm, Clemens Lowik, Yann Seimbille, Laura Mezzanotte
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8206 (2024)
Multimodality reporter gene imaging combines the sensitivity, resolution and translational potential of two or more signals. The approach has not been widely adopted by the animal imaging community, mainly because its utility in this area is unproven
Externí odkaz:
https://doaj.org/article/f73bbc45e77c492891789fc83031b3cc
Autor:
Giorgia Zambito, Siyuan Deng, Joost Haeck, Natasa Gaspar, Uwe Himmelreich, Roberta Censi, Clemens Löwik, Piera Di Martino, Laura Mezzanotte
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Tumor-associated macrophages (TAMs) promote cancer growth and metastasis, but their role in tumor development needs to be fully understood due to the dynamic changes of tumor microenvironment (TME). Here, we report an approach to visualize TAMs by op
Externí odkaz:
https://doaj.org/article/4f227a9a207c40e39d4159e458eeda96
Autor:
Giorgia Zambito, Mary P. Hall, Monika G. Wood, Natasa Gaspar, Yanto Ridwan, Fabio F. Stellari, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101986- (2021)
Summary: For in vivo multicolor bioluminescence applications, red and near-infrared signals are desirable over shorter wavelength signals because they are not as susceptible to light attenuation by blood and tissue. Herein, we describe the developmen
Externí odkaz:
https://doaj.org/article/5e26075b737543d6944527aebd715e28
Autor:
Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Red-shifted bioluminescence emission is needed to improve deep tissue imaging resolution. Here, the authors develop a click beetle red luciferase mutant and two naphthyl-luciferin substrates, and show the ability of the new luciferin/luciferase pairi
Externí odkaz:
https://doaj.org/article/f3b823b85af24f64b68c08d10040b682
Autor:
Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Non-invasive imaging technologies to visualize the location and functionality of T cells are of great value in immunology. Here, we describe the design and generation of a transgenic mouse in which all T cells constitutively express green-emitting cl
Externí odkaz:
https://doaj.org/article/77df4fbc1b0a4f46ae5f8867a008bea7
Autor:
Laura Mezzanotte, Juvita Delancy Iljas, Ivo Que, Alan Chan, Eric Kaijzel, Rob Hoeben, Clemens Löwik
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Biodistribution and fate of transplanted stem cells via longitudinal monitoring has been successfully achieved in the last decade using optical imaging. However, sensitive longitudinal imaging of transplanted stem cells in deep tissue like the brain
Externí odkaz:
https://doaj.org/article/e087aab4ac854de993ed6b138df774c6
Autor:
Marion Selt, Annette Tennstaedt, Andreas Beyrau, Melanie Nelles, Gabriele Schneider, Clemens Löwik, Mathias Hoehn
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156626 (2016)
Brain-infiltrating monocyte-derived macrophages are one of the key players in the local immune response after stroke. It is now widely accepted that the inflammatory response is not an exclusively destructive process. However, the underlying molecula
Externí odkaz:
https://doaj.org/article/a9fb51e58db5493daa359e2f9d8708cc
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19277 (2011)
BACKGROUND: Despite a plethora of bioluminescent reporter genes being cloned and used for cell assays and molecular imaging purposes, the simultaneous monitoring of multiple events in small animals is still challenging. This is partly attributable to
Externí odkaz:
https://doaj.org/article/b5740c1fd64a4bcc95d2b430caf472f6
Autor:
Peter ten Dijke, Gabri van der Pluijm, Clemens Löwik, Ivo Que, Jeroen Buijs, Maarten van Dinther, Martine Deckers
Transforming growth factor β (TGF-β) can act as suppressor and promoter of cancer progression. Intracellular Smad proteins (i.e., receptor regulated Smads and common mediator Smad4) play a pivotal role in mediating antimitogenic and proapoptotic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b988b55c7476479512beab905b9621
https://doi.org/10.1158/0008-5472.c.6494984.v1
https://doi.org/10.1158/0008-5472.c.6494984.v1
Autor:
Peter ten Dijke, Gabri van der Pluijm, Clemens Löwik, Ivo Que, Jeroen Buijs, Maarten van Dinther, Martine Deckers
Supplementary Methods, Figures 1-3 and Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ad9d2c16496aa3a75980a4c7331293
https://doi.org/10.1158/0008-5472.22366088
https://doi.org/10.1158/0008-5472.22366088