Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Clemens Holz"'
Autor:
Anna Richter, Sandra Lange, Clemens Holz, Luisa Brock, Thomas Freitag, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Rico Schwarz, Burkhard Hinz, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Dysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized b
Externí odkaz:
https://doaj.org/article/f965715f9603445aaf305e682578afd1
Autor:
Clemens Holz, Sandra Lange, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Hugo Murua Escobar, Christian Junghanss, Anna Richter
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1359 (2023)
Numerous hematologic neoplasms, including acute B-lymphoblastic leukemia (B-ALL), are characterized by overexpression of anti-apoptotic BCL-2 family proteins. Despite the high clinical efficacy of the specific BCL-2 inhibitor venetoclax in acute myel
Externí odkaz:
https://doaj.org/article/f7717778f5544ab8a8bbb6b1b39740c6
Autor:
Anna Richter, Elisabeth Fischer, Clemens Holz, Julia Schulze, Sandra Lange, Anett Sekora, Gudrun Knuebel, Larissa Henze, Catrin Roolf, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2771 (2021)
Aberrant PI3K/AKT signaling is a hallmark of acute B-lymphoblastic leukemia (B-ALL) resulting in increased tumor cell proliferation and apoptosis deficiency. While previous AKT inhibitors struggled with selectivity, MK-2206 promises meticulous pan-AK
Externí odkaz:
https://doaj.org/article/b5ee4ac4ca1641bbae64c63f204c56a3
Autor:
Vahid Momeni, Zahra Shahroodi, Margarete Hufnagl, Joamin Gonzalez-Gutierrez, Ivica Duretek, Stephan Schuschnigg, Christian Kukla, Clemens Holzer
Publikováno v:
Results in Engineering, Vol 23, Iss , Pp 102692- (2024)
Metal material extrusion (MMEX) involves the systematic deposition of material layer by layer, followed by debinding and sintering to produce fully dense metallic parts. The feedstocks, initially comprising metal powder and a binder system, are pivot
Externí odkaz:
https://doaj.org/article/728ef27743f04731847b634a2e96c609
Autor:
Mahrukh Sadaf, Santiago Cano, Mario Bragaglia, Stephan Schuschnigg, Christian Kukla, Clemens Holzer, Lilla Vály, Michael Kitzmantel, Francesca Nanni, Joamin Gonzalez-Gutierrez
Publikováno v:
Journal of Materials Research and Technology, Vol 29, Iss , Pp 4433-4444 (2024)
In the realm of material innovation, the remarkable versatility of thermoplastic-based highly filled composites emerges as a pivotal advantage for fabricating metal parts, seamlessly integrating design flexibility. This study delves into the fusion o
Externí odkaz:
https://doaj.org/article/d6ed7d17f20c4530be8c79902272573d
Autor:
Michael Habenbacher, Ulrich Moser, Ahmed Abaira, Peter Valentin Tomazic, Peter Kiss, Clemens Holzmeister, Jakob Pock, Katharina Walla, Angelika Lang, Alexandros Andrianakis
Publikováno v:
Nutrients, Vol 16, Iss 17, p 2982 (2024)
Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts quality of life and often presents therapeutic challenges, with biologics like dupilumab showing promise in managing severe, uncontrolled cases. The aim of this study was to asse
Externí odkaz:
https://doaj.org/article/4c32039929cd44c592ea550e95b0c42a
Autor:
Anett Sekora, Hugo Murua Escobar, Julia Schulze, Sandra Lange, Catrin Roolf, Anna Richter, Elisabeth Fischer, Gudrun Knuebel, Larissa Henze, Clemens Holz, Christian Junghanss
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2771, p 2771 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences
Volume 22
Issue 5
Aberrant PI3K/AKT signaling is a hallmark of acute B-lymphoblastic leukemia (B‑ALL) resulting in increased tumor cell proliferation and apoptosis deficiency. While previous AKT inhibitors struggled with selectivity, MK‑2206 promises meticulous pa
Autor:
Vahid Momeni, Sorana Luca, Joamin Gonzalez-Gutierrez, Santiago Cano, Emilie Sueur, Zahra Shahroodi, Stephan Schuschnigg, Christian Kukla, Clemens Holzer
Publikováno v:
Applied Sciences, Vol 14, Iss 13, p 5638 (2024)
The applications of Nd-Fe-B-based magnets are experiencing significant diversification to achieve efficiency and miniaturization in different technologies. Metal injection molding (MIM) provides new opportunities to manufacture Nd-Fe-B magnets with h
Externí odkaz:
https://doaj.org/article/53eed9b856e841c396f7aa996d53119e
Publikováno v:
Journal of Manufacturing and Materials Processing, Vol 8, Iss 2, p 81 (2024)
In the last fifteen years, several groups have investigated metal injection moulding (MIM) of NdFeB powder to produce isotropic or anisotropic rare earth magnets of greater geometric complexity than that achieved by the conventional pressing and sint
Externí odkaz:
https://doaj.org/article/0210d54b6aa245b1aec19af06b2bd6c8
Publikováno v:
Polymers, Vol 15, Iss 22, p 4410 (2023)
Hydrogen is recognized as a significant potential energy source and energy carrier for the future. On the one hand, storing hydrogen is a challenging task due to its low volumetric density, on the other hand, a particular type of hydrogen in the form
Externí odkaz:
https://doaj.org/article/631b4178a3c1428d9a55a4c34065847f