Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Clemens Hermann"'
Autor:
Michael O. Okpara, Clemens Hermann, Pauline J. van der Watt, Shaun Garnett, Jonathan M. Blackburn, Virna D. Leaner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Karyopherin beta 1 (Kpnβ1) is the principal nuclear importer of cargo proteins and plays a role in many cellular processes. Its expression is upregulated in cancer and essential for cancer cell viability, thus the identification of its bind
Externí odkaz:
https://doaj.org/article/b5127d1a5c7c4cec910262b86e65a9d5
Autor:
Naadir Ganief, Jessica Sjouerman, Claudia Albeldas, Kehilwe C. Nakedi, Clemens Hermann, Bridget Calder, Jonathan M. Blackburn, Nelson C. Soares
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-17 (2018)
Abstract Mycobacterium manages to evade the host cell immune system, partially owing to its ability to survive redox stress after macrophage engulfment. Exposure to redox stress has been linked to later replication, persistence, and latent infection.
Externí odkaz:
https://doaj.org/article/8b980161001e4601b85ff65570834909
Autor:
Clemens Hermann, Alexander D. Giddey, Andrew J.M. Nel, Nelson C. Soares, Jonathan M. Blackburn
Publikováno v:
MethodsX, Vol 5, Iss , Pp 475-484 (2018)
The comprehensive characterisation of the cell wall proteome of mycobacteria is of considerable relevance to both the discovery of new drug targets as well as to the design of new vaccines against Mycobacterium tuberculosis. However, due to its extre
Externí odkaz:
https://doaj.org/article/27321a622f864be680ca486b007bb655
Autor:
F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle
Publikováno v:
eLife, Vol 7 (2018)
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in com
Externí odkaz:
https://doaj.org/article/d267f215987a4db2b173a8b9f985aef6
Autor:
Andreas Neerincx, Clemens Hermann, Robin Antrobus, Andy van Hateren, Huan Cao, Nico Trautwein, Stefan Stevanović, Tim Elliott, Janet E Deane, Louise H Boyle
Publikováno v:
eLife, Vol 6 (2017)
Recently, we revealed that TAPBPR is a peptide exchange catalyst that is important for optimal peptide selection by MHC class I molecules. Here, we asked whether any other co-factors associate with TAPBPR, which would explain its effect on peptide se
Externí odkaz:
https://doaj.org/article/c132d87a727842aba0f630db881afb89
Autor:
Clemens Hermann, Andy van Hateren, Nico Trautwein, Andreas Neerincx, Patrick J Duriez, Stefan Stevanović, John Trowsdale, Janet E Deane, Tim Elliott, Louise H Boyle
Publikováno v:
eLife, Vol 4 (2015)
Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whe
Externí odkaz:
https://doaj.org/article/ada3abf3139b4cf88664e56269726921
Autor:
Paul E Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman
Publikováno v:
eLife, Vol 4 (2015)
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell sur
Externí odkaz:
https://doaj.org/article/401c28ae24f148d385a2c6b49fd379e2
Autor:
Jacob Cardenas, Jonathan M. Blackburn, Anil Pooran, Jinghua Gu, Phindile Gina, Aliasgar Esmail, Thearith Koeuth, Tawanda Gumbo, Michele Tomasicchio, Clemens Hermann, Keertan Dheda, Malika Davids, Jason Limberis, Shashikant Srivastava, L. Mottay, Fawziyah Thompson, Bridget Calder, Richard Meldau
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:1277-1291
Rationale: A human model to better understand tuberculosis immunopathogenesis and facilitate vaccine development is urgently needed.Objectives: We evaluated the feasibility, safety, and immunogenic...
The World Health Organization (WHO) estimates that Mycobacterium tuberculosis, the most pathogenic mycobacterium species to humans, has infected up to a quarter of the world's population, with the occurrence of multidrug-resistant strains on the rise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a9aec87891e90b448a4e3e7dad8d9d
https://nrc-publications.canada.ca/eng/view/object/?id=a1149c3c-6743-4d55-a12e-a6419da0a374
https://nrc-publications.canada.ca/eng/view/object/?id=a1149c3c-6743-4d55-a12e-a6419da0a374
Autor:
F. Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E. Deane, Louise H. Boyle
Publikováno v:
Molecular Immunology. 150:2