Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Clemens Giegerich"'
Autor:
Nathalie Paul, Venetia Karamitsou, Clemens Giegerich, Afshin Sadeghi, Moritz Lücke, Britta Wagenhuber, Alexander Kister, Markus Rehberg
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
In the context of in silico clinical trials, mechanistic computer models for pathophysiology and pharmacology (here Quantitative Systems Pharmacology models, QSP) can greatly support the decision making for drug candidates and elucidate the (potentia
Externí odkaz:
https://doaj.org/article/60fdcd65671c491d81e430f1da7b0bf0
Autor:
Chiara Dalla Man, Roberto Visentin, Jochen Sieber, Clemens Giegerich, Claudio Cobelli, Michele Schiavon, Thomas Klabunde
Publikováno v:
Diabetes Technology & Therapeutics
Background: Second-generation long-acting insulin glargine 300 U/mL (Gla-300) and degludec 100 U/mL (Deg-100) provide novel basal insulin therapies for the treatment of type 1 diabetes (T1D). Both offer a flatter pharmacokinetic (PK) profile than the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d349ce4e7c9d5909703b43963be8003
https://doi.org/10.1089/dia.2020.0027
https://doi.org/10.1089/dia.2020.0027
Autor:
Chiara Dalla Man, Claudio Cobelli, Roberto Visentin, Clemens Giegerich, Thomas Klabunde, Michele Schiavon
Publikováno v:
IEEE Transactions on Biomedical Engineering. 67:624-631
Objective: Subcutaneous (sc) administration of long-acting insulin analogs is often employed in multiple daily injection (MDI) therapy of type 1 diabetes (T1D) to cover patient's basal insulin needs. Among these, insulin glargine 100 U/mL (Gla-100) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e568d20aef042abcc2d1d169cb11bf72
https://doi.org/10.1109/tbme.2019.2919250
https://doi.org/10.1109/tbme.2019.2919250
Autor:
Hubert van Hoogstraten, Clemens Giegerich, Markus Rehberg, Santos Castañeda, Melitza Iglesias-Rodriguez, Jacques-Eric Gottenberg, Ernest Choy, Andreas Schwarting, A. Praestgaard, Jeffrey R. Curtis, Andrea Rubbert-Roth
Publikováno v:
Rheumatology and Therapy. 8:1921-1922
In rheumatoid arthritis, time spent using ineffective medications may lead to irreversible disease progression. Despite availability of targeted treatments, only a minority of patients achieve sustained remission, and little evidence exists to direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05728d0e46a566ba3fc31312cc81f114
https://doi.org/10.1007/s40744-021-00389-7
https://doi.org/10.1007/s40744-021-00389-7
Autor:
Thomas Klabunde, Clemens Giegerich
Background and objectiveIn March 2020 the SARS-CoV-2 outbreak has been declared as global pandemic. Most countries have implemented numerous “social distancing” measures in order to limit its transmission and control the outbreak. This study aims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227814b4a029e4d2aa1531fb62737a82
Autor:
Roberto Visentin, Claudio Cobelli, Chiara Dalla Man, Thomas Klabunde, Clemens Giegerich, Michele Schiavon
Publikováno v:
IEEE transactions on bio-medical engineering. 66(10)
Objective: Glargine 100 U/mL (Gla-100) and 300 U/mL (Gla-300) are long-acting insulin analogs providing basal insulin supply in multiple daily injection (MDI) therapy of type 1 diabetes (T1D). Both insulins require extensive testing to arrive at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9ee4dc06080b55435efa022e730943
https://pubmed.ncbi.nlm.nih.gov/30735983
https://pubmed.ncbi.nlm.nih.gov/30735983
Autor:
Chiara Dalla Man, Claudio Cobelli, Clemens Giegerich, Thomas Klabunde, Roberto Visentin, Michele Schiavon
Publikováno v:
EMBC
The University of Virginia /Padova Type 1 Diabetes (TID) simulator has been widely used for testing artificial pancreas controllers, and, recently, novel insulin formulations and glucose sensors. However, a module describing the pharmacokinetics of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069edbdc1940dd8a03be62299938a659
https://doi.org/10.1109/embc.2018.8513234
https://doi.org/10.1109/embc.2018.8513234
Autor:
Robert Jäger, Raphael Dahmen, Roberto Visentin, Anders Boss, Marshall Grant, Chiara Dalla Man, Claudio Cobelli, Thomas Klabunde, Clemens Giegerich
Publikováno v:
Diabetes Technology & Therapeutics
Background: Technosphere® insulin (TI), an inhaled human insulin with a fast onset of action, provides a novel option for the control of prandial glucose. We used the University of Virginia (UVA)/Padova simulator to explore in-silico the potential b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beda43b6c7f1d4be997209906a7a465
http://hdl.handle.net/11577/3228977
http://hdl.handle.net/11577/3228977
Autor:
Hans Matter, Clemens Giegerich, Karl-Heinz Baringhaus, Stefan Güssregen, Gerhard Hessler, Lennart T. Anger
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5352-5365
The pregnane X receptor (PXR), a member of the nuclear hormone superfamily, regulates the expression of several enzymes and transporters involved in metabolically relevant processes. The significant induction of CYP450 enzymes by PXR, in particular C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d14ded3cff935f6bce3b0ea52171dd
https://doi.org/10.1016/j.bmc.2012.04.020
https://doi.org/10.1016/j.bmc.2012.04.020