Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Clemens D Cohen"'
Autor:
Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR‐β activation, we developed a model of primary ren
Externí odkaz:
https://doaj.org/article/ac0b8d90d0994948bb0f71372a3ae50d
Autor:
Harald Seeger, Maja T Lindenmeyer, Clemens D Cohen, Carsten Jaeckel, Peter J Nelson, Jin Chen, Ilka Edenhofer, Nicolas Kozakowski, Heinz Regele, Georg Boehmig, Simone Brandt, Rudolf P Wuethrich, Mathias Heikenwalder, Thomas Fehr, Stephan Segerer
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189396 (2018)
The kidney is the most frequently transplanted solid organ. Recruitment of inflammatory cells, ranging from diffuse to nodular accumulations with defined microarchitecture, is a hallmark of acute and chronic renal allograft injury. Lymphotoxins (LTs)
Externí odkaz:
https://doaj.org/article/4d7d4d5599734c94ad237674422087b7
Autor:
Niko Braun, M Dominik Alscher, Peter Fritz, Joerg Latus, Ilka Edenhofer, Fabian Reimold, Seth L Alper, Martin Kimmel, Dagmar Biegger, Maja Lindenmeyer, Clemens D Cohen, Rudolf P Wüthrich, Stephan Segerer
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53382 (2012)
Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients
Externí odkaz:
https://doaj.org/article/3780375f658d4381bb982752e7694866
Autor:
Julia Lichtnekert, Onkar P Kulkarni, Shrikant R Mulay, Khader Valli Rupanagudi, Mi Ryu, Ramanjaneyulu Allam, Volker Vielhauer, Dan Muruve, Maja T Lindenmeyer, Clemens D Cohen, Hans-Joachim Anders
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26778 (2011)
IL-1β and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1β and IL-18 are mediators of intrinsic glomerular inflammation is unknown. In contrast to other cytokines the secretion of IL-1β and IL-
Externí odkaz:
https://doaj.org/article/521a8555240c476bb5f687afcf4bc6cf
Autor:
Peter Y Chuang, Yan Dai, Ruijie Liu, Helen He, Matthias Kretzler, Belinda Jim, Clemens D Cohen, John C He
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23566 (2011)
The number of kidney podocytes is reduced in diabetic nephropathy. Advanced glycation end products (AGEs) accumulate in patients with diabetes and promote the apoptosis of podocyte by activating the forkhead box O4 (Foxo4) transcription factor to inc
Externí odkaz:
https://doaj.org/article/c7f5ae50360e4b479665339a4480a223
Autor:
Heather N Reich, David Tritchler, Daniel C Cattran, Andrew M Herzenberg, Felix Eichinger, Anissa Boucherot, Anna Henger, Celine C Berthier, Viji Nair, Clemens D Cohen, James W Scholey, Matthias Kretzler
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13451 (2010)
Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether
Externí odkaz:
https://doaj.org/article/296a7428f6cb4c5d94f4e0b5a93a8c95
Autor:
Sandhya Xavier, Victoria Gilbert, Maria Pia Rastaldi, Stefanie Krick, Dmitrij Kollins, Anand Reddy, Erwin Bottinger, Clemens D Cohen, Detlef Schlondorff
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12995 (2010)
BAMBI (BMP and Activin Membrane Bound Inhibitor) is considered to influence TGFβ and Wnt signaling, and thereby fibrosis. Surprisingly data on cell type-specific expression of BAMBI are not available. We therefore examined the localization, gene reg
Externí odkaz:
https://doaj.org/article/c4f821be38ab4a76900f37ccce53b3e4
Autor:
Maja T Lindenmeyer, Felix Eichinger, Kontheari Sen, Hans-Joachim Anders, Ilka Edenhofer, Deborah Mattinzoli, Matthias Kretzler, Maria P Rastaldi, Clemens D Cohen
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11545 (2010)
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal g
Externí odkaz:
https://doaj.org/article/7690114fa61e42f888e5d91181bab6f3
Autor:
Anton G Moll, Maja T Lindenmeyer, Matthias Kretzler, Peter J Nelson, Ralf Zimmer, Clemens D Cohen
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4702 (2009)
Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide p
Externí odkaz:
https://doaj.org/article/ce0bc073a8e840c7af9ee4df66a8ba92
Autor:
Clemens D Cohen, Maja T Lindenmeyer, Felix Eichinger, Alexander Hahn, Martin Seifert, Anton G Moll, Holger Schmid, Eva Kiss, Elisabeth Gröne, Hermann-Josef Gröne, Matthias Kretzler, Thomas Werner, Peter J Nelson
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2937 (2008)
BACKGROUND: Diabetic nephropathy (DN) is a complex and chronic metabolic disease that evolves into a progressive fibrosing renal disorder. Effective transcriptomic profiling of slowly evolving disease processes such as DN can be problematic. The chan
Externí odkaz:
https://doaj.org/article/0947138999c84e41bcbc4877c7f3cd7e