Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Clemens Neusch"'
Autor:
Katharina Maier, Doron Merkler, Joachim Gerber, Naimeh Taheri, Antje V. Kuhnert, Sarah K. Williams, Clemens Neusch, Mathias Bähr, Ricarda Diem
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 3, Pp 514-525 (2007)
Axonal destruction and neuronal loss occur early during multiple sclerosis, an autoimmune inflammatory CNS disease that frequently manifests with acute optic neuritis. Available therapies mainly target the inflammatory component of the disease but fa
Externí odkaz:
https://doaj.org/article/2d4b984cb7c24a4187aedcb11bf1687c
Autor:
Payam Dibaj, Jana Zschüntzsch, Heinz Steffens, Jörg Scheffel, Bettina Göricke, Jochen H Weishaupt, Karim Le Meur, Frank Kirchhoff, Uwe-Karsten Hanisch, Eike D Schomburg, Clemens Neusch
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43963 (2012)
Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous, with toxicity deriving also from glia. In particular, microglia contribute to di
Externí odkaz:
https://doaj.org/article/2e89c0240a874299be60915d21fe406b
Autor:
Payam Dibaj, Heinz Steffens, Jana Zschüntzsch, Fabien Nadrigny, Eike D Schomburg, Frank Kirchhoff, Clemens Neusch
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17910 (2011)
Mutations in the enzyme superoxide dismutase-1 (SOD1) cause hereditary variants of the fatal motor neuronal disease Amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous: neurotoxicity is derived not only from mut
Externí odkaz:
https://doaj.org/article/8594083601d94213b35def1833a76df9
Publikováno v:
Muscle & Nerve. 52:911-913
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb493435f4da5608ec34e67c50510d6
https://doi.org/10.1002/mus.24751
https://doi.org/10.1002/mus.24751
Autor:
Eike D. Schomburg, Payam Dibaj, Frank Kirchhoff, Clemens Neusch, Jana Zschüntzsch, Heinz Steffens
Publikováno v:
Neuroscience Letters. 497:148-151
Pathophysiology of the motoneuron disease amyotrophic lateral sclerosis (ALS) is non-cell-autonomous. In mouse models of familiar ALS, neurotoxicity is derived not only from mutant motor neurons but also from mutant neighbouring glial cells. In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaf439719a288f446bcf1de7d5d5bba
https://doi.org/10.1016/j.neulet.2011.04.049
https://doi.org/10.1016/j.neulet.2011.04.049
Autor:
Anja Krabbenhöft, Zhe Feng, Penghong Song, Adam J. Smolka, Susan J. Hagen, Michael P. Manns, Stephanie Groos, Ursula Seidler, Brigitte Riederer, Clemens Neusch
Publikováno v:
Journal of Biological Chemistry. 286:14120-14128
Kir4.1 channels were found to colocalize with the H(+)/K(+)-ATPase throughout the parietal cell (PC) acid secretory cycle. This study was undertaken to explore their functional role. Acid secretory rates, electrophysiological parameters, PC ultrastru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28d965e23ba1de7f6aa5d964cea49fe
https://doi.org/10.1074/jbc.m110.151191
https://doi.org/10.1074/jbc.m110.151191
Autor:
Fabien Nadrigny, Eike D. Schomburg, Frank Kirchhoff, Anja Scheller, Johannes Hirrlinger, Heinz Steffens, Payam Dibaj, Clemens Neusch
Publikováno v:
Glia
Glia; Vol 58
Glia; Vol 58
To understand the pathomechanisms of spinal cord injuries will be a prerequisite to develop efficient therapies. By investigating acute lesions of spinal cord white matter in anesthetized mice with fluorescently labeled microglia and axons using in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b463f669ce82afc6ef56376915d675
https://doi.org/10.1002/glia.20993
https://doi.org/10.1002/glia.20993
Autor:
Gerald Seifert, Christian Steinhäuser, Kerstin Hüttmann, Christian Hartmann, Alexandra Wyczynski, Clemens Neusch, Devin K. Binder
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience; Vol 29
Journal of Neuroscience; Vol 29
Astrocytes in different brain regions display variable functional properties. In the hippocampus, astrocytes predominantly express time- and voltage-independent currents, but the underlying ion channels are not well defined. This ignorance is partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f788caab3fec76aa247a42655d05a582
Autor:
Ricarda Diem, Muriel B. Sättler, Sarah K. Williams, Markus Otto, Jens R. Pehlke, Mathias Bähr, Clemens Neusch
Publikováno v:
The American Journal of Pathology. 173:1496-1507
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that results in persistent impairment in young adults. During chronic progressive disease stages, there is a strong correlation between neurodegeneration and disab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d75685c5c8a65f831dd50c2c3aa4b3
https://doi.org/10.2353/ajpath.2008.080491
https://doi.org/10.2353/ajpath.2008.080491
Publikováno v:
Muscle & Nerve. 35:712-724
In classic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), the pathogenic concept of a cell-autonomous disease of motor neurons has been challenged increasingly in recent years. Macro- and microglial cells have come to the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207c26cde2d825926c7867953685c55
https://doi.org/10.1002/mus.20768
https://doi.org/10.1002/mus.20768