Macrophages coordinate immune response to laser-induced injury via extracellular traps

Autor: Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt, Volker Enzmann

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)

Abstract Background Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of resident microglia and

Externí odkaz: https://doaj.org/article/916c1fd49e544c4fb67ae384fc06888f

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis

Autor: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio, Felipe Simon

Publikováno v: Biological Research, Vol 56, Iss 1, Pp 1-32 (2023)

Abstract Background Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulati

Externí odkaz: https://doaj.org/article/c033d5e45ec04f8db7623330081fc0fe

Image-guided transplantation of single cells in the bone marrow of live animals

Autor: Raphaël Turcotte, Clemens Alt, Judith M. Runnels, Kyoko Ito, Juwell W. Wu, Walid Zaher, Luke J. Mortensen, Lev Silberstein, Daniel C. Côté, Andrew L. Kung, Keisuke Ito, Charles P. Lin

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Transplantation of a single hematopoietic stem cell is an important method for its functional characterization, but the standard transplantation protocol relies on cell homing to the bone marrow after intravenous injection. Here, we present

Externí odkaz: https://doaj.org/article/9ecda607d1944f4292e9b9f4fd7e0a35

Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.

Autor: Emmanuel S Buys, Yu-Chieh Ko, Clemens Alt, Sarah R Hayton, Alexander Jones, Laurel T Tainsh, Ruiyi Ren, Andrea Giani, Maeva Clerté, Emma Abernathy, Robert E T Tainsh, Dong-Jin Oh, Rajeev Malhotra, Pankaj Arora, Nadine de Waard, Binglan Yu, Raphael Turcotte, Daniel Nathan, Marielle Scherrer-Crosbie, Stephanie J Loomis, Jae H Kang, Charles P Lin, Haiyan Gong, Douglas J Rhee, Peter Brouckaert, Janey L Wiggs, Meredith S Gregory, Louis R Pasquale, Kenneth D Bloch, Bruce R Ksander

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e60156 (2013)

Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the α1 subunit of the nitric oxide receptor soluble guanyla

Externí odkaz: https://doaj.org/article/cdb4e77ca1f6419cb61140dd1cfbf975

Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Autor: Carare, Roxana O., Aldea, Roxana, Agarwal, Nivedita, Bacskai, Brian J., Bechman, Ingo, Boche, Delphine, Bu, Guojun, Bulters, Diederik, Clemens, Alt, Counts, Scott E., de Leon, Mony J., Eide, Per Kristian, Fossati, Silvia, Greenberg, Steven M., Hamel, Edith, Hawkes, Cheryl A., Koronyo-Hamaoui, Maya, Hainsworth, Atticus H., Holtzman, David, Ihara, Masafumi, Jefferson, Angela, Kalaria, Raj N., Kipps, Christopher M., Kanninen, Katja M., Leinonen, Ville, McLaurin, JoAnne, Miners, Scott, Malm, Tarja, Nicoll, James A. R., Piazza, Fabrizio, Paul, Gesine, Rich, Steven M., Saito, Satoshi, Shih, Andy, Scholtzova, Henrieta, Snyder, Heather, Snyder, Peter, Thormodsson, Finnbogi Rutur, van Veluw, Susanne J., Weller, Roy O., Werring, David, Wilcock, Donna, Wilson, Mark R., Zlokovic, Berislav V., Verma, Ajay

Publikováno v: Carare, Roxana O. Aldea, Roxana Agarwal, Nivedita Bacskai, Brian J. Bechman, Ingo Boche, Delphine Bu, Guojun Bulters, Diederik Clemens, Alt Counts, Scott E. de Leon, Mony J. Eide, Per Kristian Fossati, Silvia Greenberg, Steven M. Hamel, Edith Hawkes, Cheryl A. Koronyo-Hamaoui, Maya Hainsworth, Atticus H. Holtzman, David Ihara, Masafumi Jefferson, Angela Kalaria, Raj N. Kipps, Christopher M. Kanninen, Katja M. Leinonen, Ville McLaurin, JoAnne Miners, Scott Malm, Tarja Nicoll, James A. R. Piazza, Fabrizio Paul, Gesine Rich, Steven M. Saito, Satoshi Shih, Andy Scholtzova, Henrieta Snyder, Heather Snyder, Peter Thormodsson, Finnbogi Rutur van Veluw, Susanne J. Weller, Roy O. Werring, David Wilcock, Donna Wilson, Mark R. Zlokovic, Berislav V. Verma, Ajay . Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2020, 12(1)
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Externí odkaz: http://hdl.handle.net/10852/85305
https://www.duo.uio.no/bitstream/handle/10852/85305/2/Clearance%2Bof%2Binterstitial%2Bfluid%2B%2528ISF%2529%2Band%2BCSF%2B%2528CLIC%2529%2Bgroup.pdf