Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Clemence Simonin"'
Autor:
Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, Séverine Bleuse, Antoine Marchand, Alessia Sarchione, Coline Leghay, Alexandre Kreisler, Clémence Simonin, James Koprich, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Alain Destée, Marie-Christine Chartier-Harlin
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or pharmacodynamic biomarkers. The main objective of this study is therefore to assess the LRRK2-Rab pathway
Externí odkaz:
https://doaj.org/article/b7e9bd2df83248dc86dcac1c9f1e4ea1
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 83(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb61b4c652c4456a61d39584c4b6d6a4
https://pubmed.ncbi.nlm.nih.gov/22773852
https://pubmed.ncbi.nlm.nih.gov/22773852
Autor:
Moncef Jendoubi, Sanjay Aurora, Chunhua Yang, John H. Wolfe, Jonathan D. Flax, Clemence Simonin, Seung U. Kim, Ann Marie Wills, Richard L. Sidman, Lori L. Billinghurst, Evan Y. Snyder
Publikováno v:
Nature biotechnology. 16(11)
Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. These self-renewing clones give rise to all fundamental neural lineages in vitro. Following transplantation into germinal zones of the newborn mouse brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c8e850d7a9645c7b8976feaece68b6
https://pubmed.ncbi.nlm.nih.gov/9831031
https://pubmed.ncbi.nlm.nih.gov/9831031
Autor:
Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotelle
Publikováno v:
Cells, Vol 11, Iss 22, p 3631 (2022)
The Hippo pathway consists of a cascade of kinases that controls the phosphorylation of the co-activators YAP/TAZ. When unphosphorylated, YAP and TAZ translocate into the nucleus, where they mainly bind to the TEAD transcription factor family and act
Externí odkaz:
https://doaj.org/article/88352385c66045fe8c08001e4d4ad092
Autor:
Aurore Nkiliza, Eugénie Mutez, Clémence Simonin, Frédéric Leprêtre, Aurélie Duflot, Martin Figeac, Céline Villenet, Pierre Semaille, Thomas Comptdaer, Alexandre Genet, Bernard Sablonnière, David Devos, Luc Defebvre, Alain Destée, Marie-Christine Chartier-Harlin
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 312-322 (2016)
CAG triplet expansions in Ataxin-2 gene (ATXN2) cause spinocerebellar ataxia type 2 and have a role that remains to be clarified in Parkinson's disease (PD). To study the molecular events associated with these expansions, we sequenced them and analyz
Externí odkaz:
https://doaj.org/article/4297e03be61d441d96a390b2a4d9cf64
Autor:
Clémence Simonin, Cécile Duru, Julia Salleron, Pascale Hincker, Perrine Charles, Arnaud Delval, Katia Youssov, Sylvie Burnouf, Jean-Philippe Azulay, Christophe Verny, Clarisse Scherer, Christine Tranchant, Cyril Goizet, Sabrina Debruxelles, Luc Defebvre, Bernard Sablonnière, Monique Romon-Rousseaux, Luc Buée, Alain Destée, Olivier Godefroy, Alexandra Dürr, Bernhard Landwehrmeyer, Anne-Catherine Bachoud-Levi, Florence Richard, David Blum, Pierre Krystkowiak
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 179-182 (2013)
Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental evidence support that ARs play a role in Huntington's disease (HD) raising
Externí odkaz:
https://doaj.org/article/c66d747e16594f4389dca9b322499c97
Autor:
Ruth de Diego-Balaguer, Catherine Schramm, Isabelle Rebeix, Emmanuel Dupoux, Alexandra Durr, Alexis Brice, Perrine Charles, Laurent Cleret de Langavant, Katia Youssov, Christophe Verny, Vincent Damotte, Jean-Philippe Azulay, Cyril Goizet, Clémence Simonin, Christine Tranchant, Patrick Maison, Amandine Rialland, David Schmitz, Charlotte Jacquemot, Bertrand Fontaine, Anne-Catherine Bachoud-Lévi, French Speaking Huntington Group
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161106 (2016)
Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorph
Externí odkaz:
https://doaj.org/article/ce1eff47281e424abe8ed33bbb731069
Autor:
Laurent Cleret de Langavant, Sophie Sudraud, Christophe Verny, Pierre Krystkowiak, Clémence Simonin, Philippe Damier, Jean-François Demonet, Frédéric Supiot, Amandine Rialland, David Schmitz, Patrick Maison, Katia Youssov, Anne-Catherine Bachoud-Lévi
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128209 (2015)
There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Feta
Externí odkaz:
https://doaj.org/article/fb66a675a70a413f8333d73ceb1f30a9
Autor:
Gaëlle Désaméricq, Guillaume Dolbeau, Christophe Verny, Perrine Charles, Alexandra Durr, Katia Youssov, Clémence Simonin, Jean-Philippe Azulay, Christine Tranchant, Cyril Goizet, Philippe Damier, Emmanuel Broussolle, Jean-François Demonet, Graca Morgado, Laurent Cleret de Langavant, Isabelle Macquin-Mavier, Anne-Catherine Bachoud-Lévi, Patrick Maison
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85430 (2014)
PURPOSE: Huntington's disease is a rare condition. Patients are commonly treated with antipsychotics and tetrabenazine. The evidence of their effect on disease progression is limited and no comparative study between these drugs has been conducted. We
Externí odkaz:
https://doaj.org/article/b0e736cfbe4b459c9c01b06ee883f3e5
Autor:
Claire-Marie Dhaenens, Sylvie Burnouf, Clémence Simonin, Edwige Van Brussel, Alain Duhamel, Luc Defebvre, Cécile Duru, Isabelle Vuillaume, Cécile Cazeneuve, Perrine Charles, Patrick Maison, Sabrina Debruxelles, Christophe Verny, Hélène Gervais, Jean-Philippe Azulay, Christine Tranchant, Anne-Catherine Bachoud-Levi, Alexandra Dürr, Luc Buée, Pierre Krystkowiak, Bernard Sablonnière, David Blum
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 474-476 (2009)
Based on the pathophysiological role of adenosine A2A receptors in HD, we have evaluated the association of the 1976C/T single-nucleotide polymorphism in the ADORA2A gene (rs5751876) with residual age at onset (AAO) in HD. The study population consis
Externí odkaz:
https://doaj.org/article/57362044a4d4474ea38082c4323bdee7