Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Cleavage site prediction"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background MicroRNAs (miRNAs) are a class of non-coding RNAs that play a pivotal role as gene expression regulators. These miRNAs are typically approximately 20 to 25 nucleotides long. The maturation of miRNAs requires Dicer cleavage at spec
Externí odkaz:
https://doaj.org/article/da523028fc604264a044ac6d7099ff0c
Akademický článek
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Autor:
Fuyi Li, Andre Leier, Quanzhong Liu, Yanan Wang, Dongxu Xiang, Tatsuya Akutsu, Geoffrey I. Webb, A. Ian Smith, Tatiana Marquez-Lago, Jian Li, Jiangning Song
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 18, Iss 1, Pp 52-64 (2020)
Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and recycling of proteins, which is essential
Externí odkaz:
https://doaj.org/article/eee55d04a1354046a2a0f1cddc8e5385
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Understanding the substrate specificity of HIV-1 protease plays an essential role in the prevention of HIV infection. A variety of computational models have thus been developed to predict substrate sites that are cleaved by HIV-1 protease, but most o
Externí odkaz:
https://doaj.org/article/b18f69ce2ba447758ccb171d615575b2
Akademický článek
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Autor:
Noémi Miltner, Gergő Kalló, Éva Csősz, Márió Miczi, Tibor Nagy, Mohamed Mahdi, János András Mótyán, József Tőzsér
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3236
Volume 24
Issue 4
Pages: 3236
The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in its life cycle. The Mpro-mediated limited proteolysis of the viral polyproteins is necessary for the replication of the virus, and cleava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469c8212b4596772c115a94b6ceea27b
Akademický článek
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Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Understanding the substrate specificity of HIV-1 protease plays an essential role in the prevention of HIV infection. A variety of computational models have thus been developed to predict substrate sites that are cleaved by HIV-1 protease, but most o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcda1bf0238d85383f2fc25bc94c2b82
https://pubmed.ncbi.nlm.nih.gov/33868387
https://pubmed.ncbi.nlm.nih.gov/33868387
Autor:
Miczi, Márió, Golda, Mária, Kunkli, Balázs, Nagy, Tibor, Tőzsér, József, Mótyán, János András
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9523, p 9523 (2020)
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9523, p 9523 (2020)
Volume 21
Issue 24
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease-19 (COVID-19) being associated with severe pneumonia. Like with other viruses, the interaction of SARS-CoV-2 with host cell proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00015e9cf08e1b5b9e9e1ea2b1625b89
http://europepmc.org/articles/PMC7765187
http://europepmc.org/articles/PMC7765187
In silico modelling of cascade enzymatic proteolysis is an exceedingly complex and challenging task. Here, we study partial proteolysis of insulin by pepsin: a process leading to the release of a highly amyloidogenic two chain 'H-fragment'. The H-fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676bbe6a20f77401012438d4029c343b
https://ruj.uj.edu.pl/xmlui/handle/item/158876
https://ruj.uj.edu.pl/xmlui/handle/item/158876
