Výsledky vyhledávání - "Cleavage factor"

Akademický článek

Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation

Autor: Juan B. Rodríguez‐Molina, Matti Turtola

Publikováno v: FEBS Open Bio, Vol 13, Iss 7, Pp 1140-1153 (2023)

During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added

Externí odkaz: https://doaj.org/article/b14c7bcfd80d45ad853a6d801ec51990

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Akademický článek

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Akademický článek

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Akademický článek

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Dissertation/ Thesis

Functional analyses of Arabidopsis Cleavage Factor I

Autor: Zhang, Xiaojuan

甲第24082号
理博第4849号
新制||理||1694(附属図書館)
学位規則第4条第1項該当
Doctor of Science
Kyoto University
DGAM

Externí odkaz: http://hdl.handle.net/2433/275547

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Structural basis of RNA polymerase inhibition by viral and host factors

Autor: Thomas Fouqueau, David Prangishvili, Finn Werner, Dorota Matelska, Natalya Lukoyanova, Luis Miguel Díaz-Santín, Alan C. M. Cheung, Simona Pilotto, Soizick Lucas-Staat, Carol Sheppard

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, 2021, 12 (1), pp.5523. ⟨10.1038/s41467-021-25666-5⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

RNA polymerase inhibition plays an important role in the regulation of transcription in response to environmental changes and in the virus-host relationship. Here we present the high-resolution structures of two such RNAP-inhibitor complexes that pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae4eaf705b32f8514a4f45ed6258983
https://doi.org/10.1038/s41467-021-25666-5

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The Clp1 R140H mutation alters tRNA metabolism and mRNA 3′ processing in mouse models of pontocerebellar hypoplasia

Autor: Jeffrey H. Chuang, Scott I Adamson, Caitlin E. Monaghan, Mridu Kapur, Susan L. Ackerman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 39

Significance Mutation of CLP1 causes pontocerebellar hypoplasia type 10 (PCH10), a neurodegenerative disorder associated with intellectual and motor disability. We made two mouse models of PCH10: one homozygous for the mutation found in patients and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e48a51c74321e0c08d6ff12a049ed5
http://europepmc.org/articles/PMC8488643

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Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria

Autor: Zhe Sun, Peter C. FitzGerald, Mikhail Kashlev, Carl E. Mclntosh, Alexander V. Yakhnin

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Promoter-proximal pausing regulates eukaryotic gene expression and serves as checkpoints to assemble elongation/splicing machinery. Little is known how broadly this type of pausing regulates transcription in bacteria. We apply nascent elongating tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1413d979d9f6c0141374bee7b2c28a0b
http://europepmc.org/articles/PMC7876045

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CFIm25 in Solid Tumors: Current Research Progress

Autor: Ji Li, Xiaojie Sun, Xun Sun, Xiangwei Meng, Wanqi Liu

Publikováno v: Technology in Cancer Research & Treatment
Technology in Cancer Research & Treatment, Vol 19 (2020)

Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized. Alternative polyadenylation is an RNA-processing mechanism that generates distinct 3′-termini on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77db64895aeb5f4847c2647367d04cc1
http://europepmc.org/articles/PMC7350043

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RNA polymerase III subunits C37/53 modulate rU:dA hybrid 3′ end dynamics during transcription termination

Autor: Saurabh Mishra, Richard J. Maraia

Publikováno v: Nucleic Acids Research

RNA polymerase (RNAP) III synthesizes tRNAs and other transcripts, and mutations to its subunits cause human disorders. The RNAP III subunit-heterodimer C37/53 functions in initiation, elongation and in termination-associated reinitiation with subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895edd603689f074ad8d73be698e6a38
https://doi.org/10.1093/nar/gky1109

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