Scalable, compressed phenotypic screening using pooled perturbations.

Autor: Liu N; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Kattan WE; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Mead BE; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Kummerlowe C; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Cheng T; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Ingabire S; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vrcic A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McIninch JK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Triana S; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Guzman M; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Dao TT; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Peters JM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Lowder KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana Farber Cancer Institute, Boston, MA, USA., Crawford L; Microsoft Research, Cambridge, MA, USA.; Center for Computational Biology, Brown University, Providence, RI, USA.; Department of Biostatistics, Brown University, Providence, RI, USA., Amini AP; Microsoft Research, Cambridge, MA, USA., Blainey PC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Hahn WC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cleary B; Faculty of Computing and Data Sciences, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Department of Biology, Boston University, Boston, MA, USA., Bryson B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Winter PS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Raghavan S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Shalek AK; Institute for Medical Engineering and Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.; Program in Immunology, Harvard Medical School, Boston, MA, USA. shalek@mit.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. shalek@mit.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.

Key success factors in implementing allied health outreach services.

Autor: Cullenward J; Marathon Health, Dubbo, New South Wales, Australia., Hall L; Marathon Health, Dubbo, New South Wales, Australia., Cook A; Marathon Health, Dubbo, New South Wales, Australia., Ambler D; Marathon Health, Dubbo, New South Wales, Australia., Cleary B; Marathon Health, Dubbo, New South Wales, Australia., Smith T; Birrang Enterprise Development, Orange, New South Wales, Australia., Thomas M; Marathon Health, Dubbo, New South Wales, Australia.; School of Psychology, Charles Sturt University, Bathurst, New South Wales, Australia.; School of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.

Publikováno v: The Australian journal of rural health [Aust J Rural Health] 2024 Oct; Vol. 32 (5), pp. 1072-1075. Date of Electronic Publication: 2024 Sep 21.

Paternal Valproate Treatment and Risk of Childhood Neurodevelopmental Disorders: Precautionary Regulatory Measures Are Insufficiently Substantiated.

Autor: Garey JD; Reproductive Toxicology Center, A Non-Profit Foundation, Washington, DC, USA., Damkier P; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark., Scialli AR; Reproductive Toxicology Center, A Non-Profit Foundation, Washington, DC, USA., Lusskin S; Division of Medical Genetics, Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, Missouri, USA., Braddock SR; Regional Center of Pharmacovigilance, Department of Pharmacology, Cochin Port Royal Hospital, APHP, Paris, France., Chouchana L; The Rotunda Hospital, Dublin, Ireland., Cleary B; School of Pharmacy and Biomedical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Psychiatry and Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Conover EA; Division of Clinical Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA., Diav-Citrin O; The Israeli Teratology Information Service, Ministry of Health, Jerusalem, Israel.; The Hebrew University Hadassah Medical School, Jerusalem, Israel., Dragovich RS; Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA., Garcia-Bournissen F; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Hodson K; UK Teratology Information Service, Newcastle upon Tyne, UK., Kennedy D; Royal Hospital for Women, Randwick, New South Wales, Australia., Lamm SH; Center for Epidemiology and Maternal-Child Health (CEOH), Washington, DC, USA., Lavigne SA; MotherToBaby Connecticut, Division of Medical Genetics, UConn Health, Farmington, Connecticut, USA., Običan SG; Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Panchaud A; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Service of Pharmacy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Perrotta K; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA., Romeo AN; MotherToBaby Utah, Utah Department of Health, Salt Lake City, Utah, USA., Shechtman S; The Israeli Teratology Information Service, Ministry of Health, Jerusalem, Israel., Weber-Schoendorfer C; Charité - Universitätsmedizin Berlin, Pharmakovigilanzzentrum Embryonaltoxikologie, Institut für Klinische Pharmakologie und Toxikologie, Berlin, Germany.

Publikováno v: Birth defects research [Birth Defects Res] 2024 Aug; Vol. 116 (8), pp. e2392.

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VTE risk assessment, prevention and diagnosis in pregnancy.

Autor: Lutfi A; Cork University Maternity Hospital, Cork, Ireland. Electronic address: ahmed.lutfi@hse.ie., O'Rourke E; Dept of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland., Crowley M; Cork University Hospital, Cork, Ireland., Craig E; Rotunda Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland., Worrall A; Rotunda Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland., Kevane B; University College Dublin, Dublin, Ireland., O'Shaughnessy F; Rotunda Hospital, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Donnelly J; Rotunda Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland., Cleary B; Rotunda Hospital, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Áinle FN; Rotunda Hospital, Dublin, Ireland; University College Dublin, Dublin, Ireland.

Publikováno v: Thrombosis research [Thromb Res] 2024 Mar; Vol. 235, pp. 164-174. Date of Electronic Publication: 2024 Feb 03.