Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Clayton W, Winkler"'
Autor:
Clayton W. Winkler, Alyssa B. Evans, Aaron B. Carmody, Justin B. Lack, Tyson A. Woods, Karin E. Peterson
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Inflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we
Externí odkaz:
https://doaj.org/article/ded43bf8c43b416095be56e83bf5131d
Autor:
Rahul Basu, Sundar Ganesan, Clayton W. Winkler, Sarah L. Anzick, Craig Martens, Karin E. Peterson, Iain D. C. Fraser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract One of the key events in viral encephalitis is the ability of virus to enter the central nervous system (CNS). Several encephalitic viruses, including La Crosse Virus (LACV), primarily induce encephalitis in children, but not adults. This ph
Externí odkaz:
https://doaj.org/article/0f5c181a89be462b9b7e7fe061c0422c
Autor:
Alyssa B Evans, Clayton W Winkler, Sarah L Anzick, Stacy M Ricklefs, Dan E Sturdevant, Karin E Peterson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 10, p e0011657 (2023)
Since emerging in French Polynesia and Brazil in the 2010s, Zika virus (ZIKV) has been associated with fetal congenital disease. Previous studies have compared ancestral and epidemic ZIKV strains to identify strain differences that may contribute to
Externí odkaz:
https://doaj.org/article/2d7fe1e5346240ee8df74969451f67e6
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly understood. Here, we optimized the established anti-IFNAR1 treated, Rag1 −/− (AIR) mou
Externí odkaz:
https://doaj.org/article/037a6072fc4c4ab7b4c7b21e7d1e4d7c
Autor:
Rahul Basu, Vinod Nair, Clayton W. Winkler, Tyson A. Woods, Iain D. C. Fraser, Karin E. Peterson
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background A key factor in the development of viral encephalitis is a virus crossing the blood-brain barrier (BBB). We have previously shown that age-related susceptibility of mice to the La Crosse virus (LACV), the leading cause of pediatri
Externí odkaz:
https://doaj.org/article/c454f1adadeb46c8bb48913aa36125b1
Autor:
Bradley R. Groveman, Natalia C. Ferreira, Simote T. Foliaki, Ryan O. Walters, Clayton W. Winkler, Brent Race, Andrew G. Hughson, Gianluigi Zanusso, Cathryn L. Haigh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Creutzfeldt–Jakob Disease (CJD) is a fatal, currently incurable, neurodegenerative disease. The search for candidate treatments would be greatly facilitated by the availability of human cell-based models of prion disease. Recently, an indu
Externí odkaz:
https://doaj.org/article/349388bbff72452db46c3047ea9cc10f
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010384 (2022)
The California serogroup (CSG) of Orthobunyaviruses comprises several members capable of causing neuroinvasive disease in humans, including La Crosse orthobunyavirus (LACV), Jamestown Canyon orthobunyavirus (JCV), and Inkoo orthobunyavirus (INKV). De
Externí odkaz:
https://doaj.org/article/5e7b825325b243babe8cfdfc241b9222
Autor:
Clayton W. Winkler, Tyson A. Woods, Bradley R. Groveman, Aaron B. Carmody, Emily E. Speranza, Craig A. Martens, Sonja M. Best, Cathryn L. Haigh, Karin E. Peterson
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background La Crosse virus (LACV) is the leading cause of pediatric arboviral encephalitis in the USA. LACV encephalitis can result in learning and memory deficits, which may be due to infection and apoptosis of neurons in the brain. Despite
Externí odkaz:
https://doaj.org/article/ff3ab09ff3ce4d91a9e951f3612f5896
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 4, Pp 728-738 (2019)
The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of di
Externí odkaz:
https://doaj.org/article/2536165d46f94825808e0d6287cd18c5
Autor:
Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Lara Myers, Lamin B. Cham, Katrin D. Mayer-Barber, Andrea C. Bohrer, Ehydel Castro, Ying Ying Yiu, Cesar Lopez Angel, Ed Pham, Aaron B. Carmody, Ronald J. Messer, Eric Gars, Jens Kortmann, Maxim Markovic, Michaela Hasenkrug, Karin E. Peterson, Clayton W. Winkler, Tyson A. Woods, Paige Hansen, Sarah Galloway, Dhananjay Wagh, Benjamin J. Fram, Thai Nguyen, Daniel Corey, Raja Sab Kalluru, Niaz Banaei, Jayakumar Rajadas, Denise M. Monack, Aijaz Ahmed, Debashis Sahoo, Mark M. Davis, Jeffrey S. Glenn, Tom Adomati, Karl S. Lang, Irving L. Weissman, Kim J. Hasenkrug
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive compon
Externí odkaz:
https://doaj.org/article/d8f71f31b4e248b893caeb967d0cb234