Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Clayton T. Cuddington"'
Autor:
Cynthia R. Muller, Alexander T. Williams, Allyn M. Eaker, Cynthia Walser, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116789- (2024)
The widespread adoption of high-calorie, high-fat, high-sucrose diets (HFHSD) has become a global health concern, particularly due to their association with cardiovascular diseases and metabolic disorders. These comorbidities increase susceptibility
Externí odkaz:
https://doaj.org/article/b20cb5ee5fce46bfbb87368a929784a2
Autor:
Cynthia R. Muller, Alexander T. Williams, Cynthia Walser, Allyn M. Eaker, Jose Luis Sandoval, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as vasoconstriction, oxidative injury, and cardiac toxicity have prevented clinical approval of
Externí odkaz:
https://doaj.org/article/7392dcbf710e404e92a253d0ccde2b43
Autor:
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI is particularly challenging because the two therapeutic treatment strategies for TBI and HS often conflict. Ischemia/reperfusi
Externí odkaz:
https://doaj.org/article/498e933377124b19800d64b418baa677
Autor:
Zaofeng Yang, Bradley S. Heater, Clayton T. Cuddington, Andre F. Palmer, Marianne M.M. Lee, Michael K. Chan
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101158- (2020)
Summary: The effectiveness of cancer radiotherapy is frequently hindered by the hypoxia of the tumor microenvironment. Direct delivery of oxygen to hypoxic tumor tissues is an attractive strategy to overcome this hypoxia-associated radioresistance. H
Externí odkaz:
https://doaj.org/article/3f8d2c60168d45ba8c95bcbcbaf3b784
Autor:
Clayton T. Cuddington, Savannah R. Wolfe, Donald A. Belcher, Megan Allyn, Alisyn Greenfield, Xiangming Gu, Richard Hickey, Shuwei Lu, Tanmay Salvi, Andre F. Palmer
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(12)
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the oxygen (Osub2/sub) carrying capacity of PolyhHb makes it appealing as an Osub2/subthera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcd2c97ed594a7e990c48282ce3de42
https://pubmed.ncbi.nlm.nih.gov/36120842
https://pubmed.ncbi.nlm.nih.gov/36120842
Autor:
Cynthia R. Muller, Vasiliki Courelli, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Pedro Cabrales
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a241626ac45ec951268e994a6491ab
https://doi.org/10.1096/fasebj.2022.36.s1.r4206
https://doi.org/10.1096/fasebj.2022.36.s1.r4206
Autor:
Andre F. Palmer, Xiangming Gu, Donald A. Belcher, Ivan S. Pires, Chintan Savla, Crystal Bolden-Rush, Clayton T. Cuddington
Publikováno v:
Biotechnol Bioeng
Previously, our lab developed high molecular weight (MW) tense (T) quaternary state glutaraldehyde polymerized bovine hemoglobins (PolybHbs) that exhibited reduced vasoactivity in several small animal models. In this work, we prepared PolybHb in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68572d3160cd60fd485e9f681738b8a2
https://doi.org/10.1002/bit.27382
https://doi.org/10.1002/bit.27382
Autor:
Clayton T. Cuddington, Katelyn E Swindle-Reilly, Pengfei Jiang, Francisco J. Chaparro, Matthew Ohr, Andre F. Palmer, John J. Lannutti
Publikováno v:
Journal of Controlled Release. 320:442-456
Vascular endothelial growth factor (VEGF) is a key regulator of abnormal blood vessel growth. As such, bevacizumab-based inhibition of VEGF has been the clinically adopted strategy to treat colorectal and breast cancers as well as age-related macular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c605e309788d2f39af7d6fbf9da115
https://doi.org/10.1016/j.jconrel.2020.01.036
https://doi.org/10.1016/j.jconrel.2020.01.036
Publikováno v:
Bioconjugate Chemistry. 31:605-621
Polymerized human hemoglobins (PolyhHbs) are a promising class of red blood cell substitute for use in transfusion medicine. Unfortunately, the application of the commonly used glutaraldehyde cross-linking chemistry to synthesize these materials resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e421a850af5c19819d4e8a137d21c15f
https://doi.org/10.1021/acs.bioconjchem.9b00766
https://doi.org/10.1021/acs.bioconjchem.9b00766
Autor:
Cynthia R, Muller, Alexander T, Williams, Cynthia, Walser, Allyn M, Eaker, Jose Luis, Sandoval, Clayton T, Cuddington, Savannah R, Wolfe, Andre F, Palmer, Pedro, Cabrales
Publikováno v:
Scientific reports. 12(1)
For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as vasoconstriction, oxidative injury, and cardiac toxicity have prevented clinical approval of HBOCs. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1d74e797594400dd0eaade03987629c
https://pubmed.ncbi.nlm.nih.gov/36443351
https://pubmed.ncbi.nlm.nih.gov/36443351