Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Clayton R Hunt"'
Effect of HSP25 Loss on Muscle Contractile Function and Running Wheel Activity in Young and Old Mice
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Aging is associated with an adverse decline in muscle function, often manifesting as decreased strength and increased muscle fatigability that negatively affects the overall health of the elderly. Heat shock proteins (HSPs), a family of stress induci
Externí odkaz:
https://doaj.org/article/683c69cf41f34c72852df3e1c95f8380
Autor:
Tej K Pandita, Rakesh eKumar, Nobuo eHorikoshi, Mayank eSingh, Arun eGupta, Hari S Misra, Kevin eAlbuquerque, Clayton R Hunt
Publikováno v:
Frontiers in Oncology, Vol 2 (2013)
In order to survive, cells have evolved highly effective repair mechanisms to deal with the potentially lethal DNA damage produced by exposure to endogenous as well as exogenous agents. Ionizing radiation exposure induces highly lethal DNA damage, es
Externí odkaz:
https://doaj.org/article/6e5a5496b4a04ef28d7852f9aed197d8
Autor:
Mufeeda C. Koyilot, Priyadarshini Natarajan, Clayton R. Hunt, Sonish Sivarajkumar, Romy Roy, Shreeram Joglekar, Shruti Pandita, Carl W. Tong, Shamsudheen Marakkar, Lakshminarayanan Subramanian, Shalini S. Yadav, Anoop V. Cherian, Tej K. Pandita, Khader Shameer, Kamlesh K. Yadav
Publikováno v:
Cells, Vol 11, Iss 11, p 1828 (2022)
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular. The chi
Externí odkaz:
https://doaj.org/article/ec76c407c4e24247829ad3d96f115c25
Autor:
Chandrima Das, Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini S. Yadav, Santanu Adhikary, Clayton R. Hunt, Kamlesh K. Yadav, Shruti Pandita, Siddhartha Roy, John A. Tainer, Zamal Ahmed, Tej K. Pandita
Publikováno v:
Cancer Research. 83:657-666
Therapy resistance is imposing a daunting challenge on effective clinical management of breast cancer. Although the development of resistance to drugs is multifaceted, reprogramming of energy metabolism pathways is emerging as a central but heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c22b8a4fcac05124398e184f508a3f3
https://doi.org/10.1158/0008-5472.can-22-3015
https://doi.org/10.1158/0008-5472.can-22-3015
Related Article from Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a9389b904ccfd53d99fc6f8ceb97eb
https://doi.org/10.1158/1078-0432.22443486.v1
https://doi.org/10.1158/1078-0432.22443486.v1
The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf379b8cffd2c51ad23dd50d1694b3c5
https://doi.org/10.1158/1078-0432.c.6519834.v1
https://doi.org/10.1158/1078-0432.c.6519834.v1
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Supplementary Figure Legend, Methods and Materials, Tables 1-2. Supplementary Table 1. Phase distribution in cells after enrichment by synchronization. Supplementary Table 2. Effect of Ssb1 depletion on spontaneous chromosome aberration frequency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9376887e2277d860429acc3b9d1d1a85
https://doi.org/10.1158/0008-5472.22408032.v1
https://doi.org/10.1158/0008-5472.22408032.v1
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Supplementary Figures 1-5. Supplementary Fig. 1. Analysis of single-strand G-overhang by native and denatured DNA gel electrophoresis. Supplementary Fig. 2. Telomere FISH analysis of chromosomal aberrations induced by Ssb1 depletion in mouse and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44723f8f316ecae9017804c6826b09a4
https://doi.org/10.1158/0008-5472.22408029
https://doi.org/10.1158/0008-5472.22408029
Autor:
Tej K. Pandita, John-Stephen A. Taylor, Jerry W. Shay, David Pratt, Raj K. Pandita, Saira Khan, Xuan Yue, Arun Gupta, Clayton R. Hunt, Shruti Pandita, Manjula Agarwal
Hyperthermia is a potent sensitizer of cell killing by ionizing radiation (IR); however, hyperthermia also induces heat shock protein 70 (HSP70) synthesis and HSP70 expression is associated with radioresistance. Because HSP70 interacts with the telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e44245371ba36e4685e3b9bd98ef6a9
https://doi.org/10.1158/0008-5472.c.6498411
https://doi.org/10.1158/0008-5472.c.6498411
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs and maintain telomere ends. Telomerase-expressing cells also have higher levels of the single-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d699f59cee1d137562b5d706ffd738
https://doi.org/10.1158/0008-5472.c.6507444.v1
https://doi.org/10.1158/0008-5472.c.6507444.v1