Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Clayton E Friedman"'
Autor:
Alexander Loiben, Clayton E. Friedman, Wei-Ming Chien, April Stempien-Otero, Shin Lin, Kai-Chun Yang
Publikováno v:
Stem Cell Research, Vol 66, Iss , Pp 102987- (2023)
Arrhythmogenic cardiomyopathy is an inheritable heart disease characterized by lethal heart rhythms and abnormal contractile function. Mutations in desmoplakin (DSP), a protein linking the cardiac desmosome with intermediate filaments, are associated
Externí odkaz:
https://doaj.org/article/08fde0cbcf024d3289ecd1a94d9ae755
Autor:
Michael Alexanian, Daniel Maric, Stephen P. Jenkinson, Marco Mina, Clayton E. Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L. Leib, Nathan J. Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripoten
Externí odkaz:
https://doaj.org/article/0401f32188554c209d1d26fb94e3d2e8
Autor:
Alexander M. Loiben, Wei-Ming Chien, Clayton E. Friedman, Leslie S.-L. Chao, Gerhard Weber, Alex Goldstein, Nathan J. Sniadecki, Charles E. Murry, Kai-Chun Yang
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4909
Volume 24
Issue 5
Pages: 4909
Missense mutations in myosin heavy chain 7 (MYH7) are a common cause of hypertrophic cardiomyopathy (HCM), but the molecular mechanisms underlying MYH7-based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db90e91ad91356ad01ca00d3b57e854
Autor:
Clayton E. Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Linda Tran, Leslie Chao, Ashley Mckinstry, Elaheh Karbassi, Aidan M. Fenix, Alexander Loiben, Charles E. Murry, Lea M. Starita, Douglas M. Fowler, Kai-Chun Yang
Publikováno v:
bioRxiv
SUMMARYStandard transgenic cell line generation requires screening 100-1000s of colonies to isolate correctly edited cells. We describeCRISPRaOn-TargetEditingRetrieval (CRaTER) which enriches for cells with on-target knock-in of a cDNA-fluorescent re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44853a4cf343a890681fde377732f725
https://doi.org/10.1101/2023.01.25.525582
https://doi.org/10.1101/2023.01.25.525582
Autor:
Alexander M. Loiben, Wei-Ming Chien, Clayton E. Friedman, Leslie S-L. Chao, Gerhard Weber, Alex Goldstein, Nathan Sniadecki, Charles E. Murry, Kai-Chun Yang
Publikováno v:
bioRxiv
Missense mutations in myosin heavy chain 7 (MYH7) are a common cause of hyper-trophic cardiomyopathy (HCM), but the molecular mechanisms underlyingMYH7-based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2828e46a648c7d4941318907d1c5b7
https://doi.org/10.1101/2023.01.24.525458
https://doi.org/10.1101/2023.01.24.525458
Autor:
Holly K. Voges, Simon R. Foster, Liam Reynolds, Benjamin L. Parker, Lynn Devilée, Gregory A. Quaife-Ryan, Patrick R.J. Fortuna, Ellen Mathieson, Rebecca Fitzsimmons, Mary Lor, Christopher Batho, Janice Reid, Mark Pocock, Clayton E. Friedman, Dalia Mizikovsky, Mathias Francois, Nathan J. Palpant, Elise J. Needham, Marina Peralta, Gonzalo del Monte-Nieto, Lynelle K. Jones, Ian M. Smyth, Neda R. Mehdiabadi, Francesca Bolk, Vaibhao Janbandhu, Ernestene Yao, Richard P. Harvey, James J.H. Chong, David A. Elliott, Edouard G. Stanley, Sophie Wiszniak, Quenten Schwarz, David E. James, Richard J. Mills, Enzo R. Porrello, James E. Hudson
Refereed/Peer-reviewed Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction, and utility in disease modeling. Herein w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998951ca54fee675a01326833731eca
https://hdl.handle.net/11541.2/34444
https://hdl.handle.net/11541.2/34444
Autor:
Clayton E. Friedman, Seth W. Cheetham, Richard J. Mills, Masahito Ogawa, Meredith A. Redd, Han Sheng Chiu, Sophie Shen, Yuliangzi Sun, Dalia Mizikovsky, Romaric Bouveret, Xiaoli Chen, Holly Voges, Scott Paterson, Jessica E. De Angelis, Stacey B. Andersen, Sohye Yoon, Geoffrey J. Faulkner, Kelly A. Smith, Richard P. Harvey, Benjamin M. Hogan, Quan Nguyen, Kazu Kikuchi, James E. Hudson, Nathan J. Palpant
SUMMARYThis study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. Time-course single-cell gene expression with genome-wide footprinting r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353c9ee00ea26014ac95e0d230bf6bcb
https://doi.org/10.1101/2022.04.17.488603
https://doi.org/10.1101/2022.04.17.488603
Publikováno v:
Circulation Research. 129
Introduction: Familial hypertrophic cardiomyopathy (HCM), affecting 1 in 500 adults, is characterized by idiopathic thickening of the heart and occasional impaired systolic function. Mechanisms through which cardiac sarcomeric mutations manifest in H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb7dae9ff8699b01627981578cf02cd1
https://doi.org/10.1161/res.129.suppl_1.p491
https://doi.org/10.1161/res.129.suppl_1.p491
Autor:
Jing-Dong J. Han, Charles E. Murry, Anne Senabouth, Patrick P.L. Tam, Naihe Jing, Ziv Bar-Joseph, Nathan J. Palpant, Guangdun Peng, Shengbao Suo Suo, Clayton E. Friedman, Quan Nguyen, Timothy J. C. Bruxner, Angelika N. Christ, Jun Ding, Joseph E. Powell, James E. Hudson, Holly K. Voges, Han Sheng Chiu, Emily S. W. Wong, Yuliang Wang, Greg J. Baillie, Pierre Osteil, Samuel W. Lukowski, Abbigail Helfer
Publikováno v:
SSRN Electronic Journal.
Differentiation into diverse cell lineages requires orchestration of gene regulatory networks guiding cell fate choices. Here, we present the dissection of cellular composition and gene networks from transcriptomic data of 43,168 cells across five di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfce161c2d58e09ad44aa4c4ac7a37d
https://doi.org/10.2139/ssrn.3155757
https://doi.org/10.2139/ssrn.3155757
Autor:
Clayton E Friedman, Quan Nguyen, Samuel W Lukowski, Han Sheng Chiu, Abbigail Helfer, Jason Miklas, Shengbao Suo Suo, Jing-Dong Jackie Han, Pierre Osteil, Guangdun Peng, Naihe Jing, Greg J Baillie, Anne Senabouth, Angelika N Christ, Timothy J Bruxner, Charles E Murry, Emily S Wong, Jun Ding, Yuliang Wang, James Hudson, Hannele Ruohola-Baker, Ziv Bar-Joseph, Patrick P L Tam, Joseph E Powell, Nathan J Palpant
Differentiation into diverse cell lineages requires the orchestration of gene regulatory networks guiding diverse cell fate choices. Utilizing human pluripotent stem cells, we measured expression dynamics of 17,718 genes from 43,168 cells across five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b015ad971c0b6834570f4c0c3ac71a7d
https://doi.org/10.1101/229294
https://doi.org/10.1101/229294