Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Clayton D. Knox"'
Autor:
Clayton D. Knox, Pieter‐Jan deKam, Karim Azer, Peggy Wong, Antwan G. Ederveen, Diane Shevell, Christopher Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean Francois Denef, Anna Mitselos, Daniel Jonathan, David E. Gutstein, Kaushik Mitra, Shu Yu Sun, Michael Man‐Chu Lo, Doris Cully, Amjad Ali
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri
Externí odkaz:
https://doaj.org/article/7cd174d677244bd59548edc692b1ac0a
Autor:
Clayton D. Knox, Amit Mahipal, Heather Hirsch, Neeta Somaiah, Andrew J. Wagner, Amy O. Johnson-Levonas, Giuseppe Russo, David S. Hong, Raymond L. H. Lam, Shelonitda Rose, Udai Banerji, Craig Fancourt, Amy Meister
Publikováno v:
Journal of Clinical Oncology. 35:1304-1311
Purpose To evaluate MK-8242 in patients with wild-type TP53 advanced solid tumors. Patients and Methods MK-8242 was administered orally twice a day on days 1 to 7 in 21-day cycles. The recommended phase II dose (RP2D) was determined on the basis of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d77afcdf8e2fbafe41e84e2fec7e76
https://doi.org/10.1200/jco.2016.70.7117
https://doi.org/10.1200/jco.2016.70.7117
Autor:
David E. Gutstein, Christopher J. Morabito, Anna Mitselos, Kaushik Mitra, Wen Liu, Peggy H. Wong, Doris F. Cully, Karim Azer, Shu Yu Sun, Clayton D. Knox, Antwan G. Ederveen, Pieter‐Jan de Kam, Michael Man-Chu Lo, Tom Reynders, Alan G. Meehan, Daniel Jonathan, Amjad Ali, Jean Francois Denef, Diane Shevell
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e3bef922e3d1888227722e6fba249
http://europepmc.org/articles/PMC5079016
http://europepmc.org/articles/PMC5079016
Autor:
Hagop M. Kantarjian, Clayton D. Knox, Raoul Tibes, Ivana Gojo, Farhad Ravandi, Craig Fancourt, Amy O. Johnson-Levonas, Raymond L. H. Lam, Shelonitda Rose, Mary Beth Jones, Mark D. Minden, Payal Shah Patel, Mrinal M. Patnaik
Publikováno v:
Leukemia research. 48
Objective Evaluate safety/tolerability/efficacy of MK-8242 in subjects with refractory/recurrent AML. Methods MK-8242 was dosed p.o. QD (30–250 mg) or BID (120–250 mg) for 7on/7off in 28-day cycle. Dosing was modified to 7on/14off, in 21-day cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a147272212bd5e2de79d7d48cc4d9
https://pubmed.ncbi.nlm.nih.gov/27544076
https://pubmed.ncbi.nlm.nih.gov/27544076
Autor:
Andrey E. Belous, Truman M. Earl, Clayton D. Knox, Ian B. Nicoud, Christopher D. Anderson, Ravi S. Chari, Janene Pierce, Christopher M. Jones
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G623-G630
Ischemia-reperfusion (I/R) injury is a commonly encountered clinical problem in liver surgery and transplantation. The pathogenesis of I/R injury is multifactorial, but mitochondrial Ca2+ overload plays a central role. We have previously defined a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e778a37124110184d1967ad477da90
https://doi.org/10.1152/ajpgi.00521.2006
https://doi.org/10.1152/ajpgi.00521.2006
Autor:
Janene Pierce, Christopher D. Anderson, Clayton D. Knox, Christopher M. Jones, Ian B. Nicoud, Andrey E. Belous, Ravi S. Chari
Publikováno v:
Transplantation. 81:567-572
Background. Graft failure due to cold ischemia (CI) injury remains a significant problem during liver transplantation. During CI, the consumption ofATP and the increase in cellular Ca 2+ concentration may result in mitochondrial Ca 2+ (mCa 2+ ) overl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032ae91cadb13db41fb6ab99374b6097
https://doi.org/10.1097/01.tp.0000199267.98971.77
https://doi.org/10.1097/01.tp.0000199267.98971.77
Autor:
Christopher D. Anderson, Janene Pierce, Ian B. Nicoud, Clayton D. Knox, Andrey E. Belous, Ravi S. Chari
Publikováno v:
Liver Transplantation. 11:663-668
Hepatic warm ischemia and reperfusion (IR) injury occurs in many clinical situations and has an important link to subsequent hepatic failure. The pathogenesis of this injury involves numerous pathways, including mitochondrial-associated apoptosis. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7cc0dcdafec96919a814d2146d914c
https://doi.org/10.1002/lt.20407
https://doi.org/10.1002/lt.20407
Autor:
Andrey E. Belous, Clayton D. Knox, C. Wright Pinson, Aya Wakata, Christopher D. Anderson, Ian B. Nicoud, Ravi S. Chari, Janene Pierce
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 287:G533-G540
Mitochondrial Ca2+(mCa2+) handling is an important regulator of liver cell function that controls events ranging from cellular respiration and signal transduction to apoptosis. Cytosolic Ca2+enters mitochondria through the ruthenium red-sensitive mCa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6122c582a21dc96efa3e5510c73379
https://doi.org/10.1152/ajpgi.00050.2004
https://doi.org/10.1152/ajpgi.00050.2004
Autor:
C. Wright Pinson, Aya Wakata, Ravi S. Chari, Christopher D. Anderson, Clayton D. Knox, Andrey E. Belous, Ian B. Nicoud, Janene Pierce
Publikováno v:
American Journal of Transplantation. 4:352-362
Mitochondrial calcium (mCa + 2) overload occurs during cold preservation and is an integral part of mitochondrial-dependent apoptotic pathways. We investigated the role of mCa + 2 overload in cell death following hypothermic storage using HepG2 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da582f694418f6ee09b583561ba30ce
https://doi.org/10.1111/j.1600-6143.2004.00357.x
https://doi.org/10.1111/j.1600-6143.2004.00357.x
Autor:
Christopher D. Anderson, Clayton D. Knox, Ravi S. Chari, Andrey E. Belous, C. Wright Pinson, Janene Pierce, Ian B. Nicoud
Publikováno v:
Transplantation. 75:1717-1723
Graft dysfunction as a result of preservation injury remains a major clinical problem in liver transplantation. This is related in part to accumulation of mitochondrial calcium. In an attempt to sustain cell and mitochondrial integrity during ischemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054a04facbee7e6c83338d59abd9f4ff
https://doi.org/10.1097/01.tp.0000063829.35871.ce
https://doi.org/10.1097/01.tp.0000063829.35871.ce