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Akademický článek

A non-canonical striatopallidal Go pathway that supports motor control

Autor: Marie A. Labouesse, Arturo Torres-Herraez, Muhammad O. Chohan, Joseph M. Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay O. Lacefield, Jordi Bonaventura, Michael Michaelides, C. Savio Chan, Ofer Yizhar, Christoph Kellendonk

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSP

Externí odkaz: https://doaj.org/article/81d980c17c3448e59ac7e2551e221f37

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Akademický článek

Protocol for in vivo imaging and analysis of brainstem neuronal activity in the dorsal raphe nucleus of freely behaving mice

Autor: Grace E. Paquelet, Kassandra Carrion, Clay O. Lacefield, Pengcheng Zhou, Rene Hen, Bradley R. Miller

Publikováno v: STAR Protocols, Vol 4, Iss 1, Pp 102074- (2023)

Summary: In vivo brainstem imaging with miniature microscopy has been challenging due to surgical difficulty, high motion, and correlated activity between neurons. Here, we present a protocol for brainstem imaging in freely moving mice using the dors

Externí odkaz: https://doaj.org/article/fbbbb997aec24f0492747bb31544f922

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Akademický článek

A device for stereotaxic viral delivery into the brains of neonatal mice

Autor: Pedro R Olivetti, Clay O Lacefield, Christoph Kellendonk

Publikováno v: BioTechniques, Vol 69, Iss 4, Pp 307-312 (2020)

The increasing interest in manipulating neural circuits in developing brains has created a demand for reliable and accurate methods for delivering viruses to newborn mice. Here we describe a novel 3D-printed mouse neonatal stereotaxic adaptor for int

Externí odkaz: https://doaj.org/article/95705d02a8334c00b98877eafc0304b2

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Akademický článek

Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex

Autor: Clay O. Lacefield, Eftychios A. Pnevmatikakis, Liam Paninski, Randy M. Bruno

Publikováno v: Cell Reports, Vol 26, Iss 8, Pp 2000-2008.e2 (2019)

Summary: The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range co

Externí odkaz: https://doaj.org/article/3af0ff659f344830b7b2b9b3818695b1

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