The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.

Autor: Baumgartner CK; AbbVie, North Chicago, IL, USA. christina.baumgartner@abbvie.com., Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Pfizer, Groton, CT, USA., Hamel KM; AbbVie, North Chicago, IL, USA., Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Davis TGR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., McGuire KA; AbbVie, North Chicago, IL, USA., Halvorsen GT; AbbVie, North Chicago, IL, USA., Avila OI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel CH; Calico Life Sciences, South San Francisco, CA, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kammula AV; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Halliwill K; AbbVie, South San Francisco, CA, USA., Geda P; AbbVie, North Chicago, IL, USA.; Bristol Myers Squibb, Summit, NJ, USA., Klinge KL; AbbVie, North Chicago, IL, USA., Xiong Z; AbbVie, North Chicago, IL, USA.; Ipsen Biosciences, Cambridge, MA, USA., Duggan R; AbbVie, North Chicago, IL, USA., Mu L; AbbVie, North Chicago, IL, USA., Yeary MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patti JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Balon TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Mathew R; AbbVie, South San Francisco, CA, USA., Backus C; AbbVie, South San Francisco, CA, USA., Kennedy DE; AbbVie, North Chicago, IL, USA., Chen A; AbbVie, North Chicago, IL, USA., Longenecker K; AbbVie, North Chicago, IL, USA., Klahn JT; AbbVie, North Chicago, IL, USA., Hrusch CL; AbbVie, North Chicago, IL, USA., Krishnan N; AbbVie, North Chicago, IL, USA.; Monte Rosa Therapeutics, Boston, MA, USA., Hutchins CW; AbbVie, North Chicago, IL, USA., Dunning JP; AbbVie, North Chicago, IL, USA., Bulic M; AbbVie, North Chicago, IL, USA., Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Colvin KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Chuong CL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kohnle IC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boghossian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Suermondt JSMT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Knudsen NH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cheruiyot CK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sen DR; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., El-Bardeesy N; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Decker JH; AbbVie, North Chicago, IL, USA., Yang Y; AbbVie, North Chicago, IL, USA., Guffroy M; AbbVie, North Chicago, IL, USA., Fossey S; AbbVie, North Chicago, IL, USA., Trusk P; AbbVie, North Chicago, IL, USA., Sun IM; Calico Life Sciences, South San Francisco, CA, USA., Liu Y; Calico Life Sciences, South San Francisco, CA, USA., Qiu W; AbbVie, North Chicago, IL, USA., Sun Q; AbbVie, North Chicago, IL, USA., Paddock MN; Calico Life Sciences, South San Francisco, CA, USA., Farney EP; AbbVie, North Chicago, IL, USA., Matulenko MA; AbbVie, North Chicago, IL, USA., Beauregard C; Calico Life Sciences, South San Francisco, CA, USA.; Vir Biotechnology, San Francisco, CA, USA., Frost JM; AbbVie, North Chicago, IL, USA. jennifer.frost@abbvie.com., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org., Kym PR; AbbVie, North Chicago, IL, USA. phil.r.kym@abbvie.com., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.

Publikováno v: Nature [Nature] 2023 Oct; Vol. 622 (7984), pp. 850-862. Date of Electronic Publication: 2023 Oct 04.

Water-soluble PDE4 inhibitors for the treatment of dry eye.

Autor: Govek SP; Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, United States. sgovek@san.rr.com, Oshiro G, Anzola JV, Beauregard C, Chen J, Coyle AR, Gamache DA, Hellberg MR, Hsien JN, Lerch JM, Liao JC, Malecha JW, Staszewski LM, Thomas DJ, Yanni JM, Noble SA, Shiau AK

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 May 01; Vol. 20 (9), pp. 2928-32. Date of Electronic Publication: 2010 Mar 07.

Keratocyte apoptosis and failure of corneal allografts.

Autor: Beauregard C; Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA., Huq SO, Barabino S, Zhang Q, Kazlauskas A, Dana MR

Publikováno v: Transplantation [Transplantation] 2006 Jun 15; Vol. 81 (11), pp. 1577-82.

Cutting edge: atopy promotes Th2 responses to alloantigens and increases the incidence and tempo of corneal allograft rejection.

Autor: Beauregard C; Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA., Stevens C, Mayhew E, Niederkorn JY

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Jun 01; Vol. 174 (11), pp. 6577-81.

Down regulation of interleukin-1beta-induced nitric oxide production in lacrimal gland acinar cells by sex steroids.

Autor: Beauregard C; Department of Medical Pharmacology and Toxicology, Texas A & M System Health Sciences Center, Texas A&M University, College Station, TX 77843-1114, USA., Brandt P

Publikováno v: Current eye research [Curr Eye Res] 2004 Jul; Vol. 29 (1), pp. 59-66.