Zobrazeno 1 - 10 of 159 pro vyhledávání: '"Clay C C Wang"'
1
Akademický článek
The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.
Autor: Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175471 (2017)
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules
Externí odkaz: https://doaj.org/article/24cfec8821904a04985a5c129a085c71
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2
Akademický článek
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.
Autor: Erwin Berthier, Fang Yun Lim, Qing Deng, Chun-Jun Guo, Dimitrios P Kontoyiannis, Clay C C Wang, Julie Rindy, David J Beebe, Anna Huttenlocher, Nancy P Keller
Publikováno v: PLoS Pathogens, Vol 9, Iss 4, p e1003289 (2013)
The secondary metabolome provides pathogenic fungi with a plethoric and versatile panel of molecules that can be deployed during host ingress. While powerful genetic and analytical chemistry methods have been developed to identify fungal secondary me
Externí odkaz: https://doaj.org/article/8ae9616b3bbb4715a47a40d4e4c2844a
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3
Akademický článek
Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation.
Autor: Wan-Chi Lin, Yu-Chi Chuang, Yung-Sheng Chang, Ming-Derg Lai, Yen-Ni Teng, Ih-Jen Su, Clay C C Wang, Kuan-Han Lee, Jui-Hsiang Hung
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e39120 (2012)
Induction of apoptosis by endoplasmic reticulum (ER) stress is implicated as the major factor in the development of multiple diseases. ER stress also appears to be a potentially useful major response to many chemotherapeutic drugs and environmental c
Externí odkaz: https://doaj.org/article/ace8b12eed0745f39a79c9c97ba08134
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4
Akademický článek
Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells.
Autor: Jui-Hsiang Hung, Yen-Ni Teng, Lily Hui-Ching Wang, Ih-Jen Su, Clay C C Wang, Wenya Huang, Kuan-Han Lee, Kuan-Ying Lu, Lyu-Han Wang
Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28977 (2011)
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor prognosis due to resistance to conventional chemotherapy and limited efficacy of radiotherapy. Our previous studies have indicated that expression o
Externí odkaz: https://doaj.org/article/a56e360a66b14670ab1252aab9fb6bc9
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6
Manipulation of the Global Regulator
Autor: Bo, Yuan, Nancy P, Keller, Berl R, Oakley, Jason E, Stajich, Clay C C, Wang
Publikováno v: ACS chemical biology. 17(10)
Genome sequencing of filamentous fungi has demonstrated that most secondary metabolite biosynthetic gene clusters (BGCs) are silent under standard laboratory conditions. In this work, we have established an in vitro CRISPR-Cas9 system in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::643cf52720bd40fbfa9cd60adebb125f
https://pubmed.ncbi.nlm.nih.gov/36197945
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