Výsledky vyhledávání - "Clay B. Frederick"

Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes

Autor: Sudha S. Shankar, Chan R. Beals, Deborah L. Miller, S. Aubrey Stoch, Amy K. O’Dowd, Barnali Pramanik, Lori A. Mixson, Clay B. Frederick, Helmut O. Steinberg, R. Ravi Shankar, David E. Kelley, Donna M. Williams

Publikováno v: Diabetes. 67(6)

Oxyntomodulin (OXM), an enteroendocrine hormone, causes appetite suppression, increased energy expenditure, and weight loss in obese humans via activation of GLP-1 and glucagon receptors. However, the effects of OXM on glucose homeostasis remain ill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c44efd78479307a191f27b4c9f349
https://pubmed.ncbi.nlm.nih.gov/29545266

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Characterization of the Exocrine Pancreas in the Male Zucker Diabetic Fatty Rat Model of Type 2 Diabetes Mellitus Following 3 Months of Treatment With Sitagliptin

Autor: Daniel J. Holder, Clay B. Frederick, Adam Smith, Caron L. Cunningham, Xiaorui Yao, Srinivasa Prahalada, Markus Dey, Thomas Forest

Publikováno v: Endocrinology. 155:783-792

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor-based incretin therapy intended for the treatment of type 2 diabetes mellitus (T2DM), has not been linked to adverse effects on the pancreas in prospective clinical trials or in nonclinical toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb38b29a3d81601998cfc200fa55fef4
https://doi.org/10.1210/en.2013-1781

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Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats

Autor: Jeffery W Lawrence, Clay B. Frederick, William H. Schaefer, Dana A. Stoffregen, Amy F Loughlin, Dennis C. Dean, George R. Lankas, Nathan X. Yu, Lori Mixson, Conrad E. Raab

Publikováno v: Toxicology and Applied Pharmacology. 194:10-23

As a class, hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors can potentially cause skeletal myopathy. One statin, cerivastatin, has recently been withdrawn from the market due to an unacceptably high incidence of rhabdomyolysis. The me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad9b70146d06ef54ddd496575cdb829
https://doi.org/10.1016/j.taap.2003.08.013

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Physiologically Based Pharmacokinetic (PBPK) Models for Nasal Tissue Dosimetry of Organic Esters: Assessing the State-of-Knowledge and Risk Assessment Applications with Methyl Methacrylate and Vinyl Acetate

Autor: Trevor Green, Melvin E. Andersen, Matthew S. Bogdanffy, Clay B. Frederick

Publikováno v: Regulatory Toxicology and Pharmacology. 36:234-245

Mathematical models have been developed to describe nasal epithelial tissue dosimetry with two compounds, vinyl acetate (VA) and methyl methacrylate (MMA), that cause toxicity in these tissues These models couple computational fluid dynamics (CFD) ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8efa87409cb75f691d9592698684d2e
https://doi.org/10.1006/rtph.2002.1576

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Improving Risk Assessment: Toxicological Research Needs

Autor: Ellen Silbergeld, Ronald Melnick, Paul Foster, Matthew S. Bogdanffy, Harri Vainio, Kevin Morgan, Mark Toraason, Val Schaeffer, William Slikker, Roger O. McClellan, David Dankovic, Clay B. Frederick, Lynne T. Haber, Mel Andersen, Steven C. Lewis, Elaine Faustman, Frank Mirer, James Swenberg, Carole A. Kimmel

Publikováno v: Human and Ecological Risk Assessment: An International Journal. 8:1405-1419

A workshop convened to define research needs in toxicology identified several deficiencies in data and methods currently applied in risk assessment. The workshop panel noted that improving the link between chemical exposure and toxicological response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6105489fe4ef74f1247f46ad64b13d8f
https://doi.org/10.1080/20028091057439

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A HYBRID COMPUTATIONAL FLUID DYNAMICS AND PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR COMPARISON OF PREDICTED TISSUE CONCENTRATIONS OF ACRYLIC ACID AND OTHER VAPORS IN THE RAT AND HUMAN NASAL CAVITIES FOLLOWING INHALATION EXPOSURE

Autor: Ultman Js, Morris Jb, Finch L, Subramaniam Rp, Black Ka, Gentry Pr, Bush Ml, Julia S. Kimbell, Morgan Kt, Clay B. Frederick, Lomax Lg

Publikováno v: Inhalation Toxicology. 13:359-376

To assist in interspecies dosimetry comparisons for risk assessment of the nasal effects of organic acids, a hybrid computational fluid dynamics (CFD) and physiologically based pharmacokinetic (PBPK) dosimetry model was constructed to estimate the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2483fb726aa93a06ba88a9f86349608e
https://doi.org/10.1080/08958370151126248

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Application of a Hybrid CFD-PBPK Nasal Dosimetry Model in an Inhalation Risk Assessment: An Example with Acrylic Acid

Autor: Ramesh Sarangapani, Tammie R. Covington, Harvey J. Clewell, Melvin E. Andersen, Robinan Gentry, Clay B. Frederick

Publikováno v: Scopus-Elsevier

The available inhalation toxicity information for acrylic acid (AA) suggests that lesions to the nasal cavity, specifically olfactory degeneration, are the most sensitive end point for developing a reference concentration (RfC). Advances in physiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee5fb37772ed76db1780b190709e6f8
https://doi.org/10.1093/toxsci/57.2.312

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DOSIMETRIC ADJUSTMENT FACTORS FOR METHYL METHACRYLATE DERIVED FROM A STEADY-STATE ANALYSIS OF A PHYSIOLOGICALLY BASED CLEARANCE-EXTRACTION MODEL

Autor: Melvin E. Andersen, Ramesh Sarangapani, Julia S. Kimbell, Clay B. Frederick

Publikováno v: Inhalation Toxicology. 11:899-926

Cells within the epithelial lining of the nasal cavity metabolize a variety of low-molecular-weight, volatile xenobiotics. In common with terminology developed for other metabolizing organs, the nose extracts these chemicals from the airstream, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0f0785d693426a1da1df05f90b356b
https://doi.org/10.1080/089583799196709

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