Biochemical and metabolic characterization of a G6PC2 inhibitor.

Autor: Hawes EM; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Rahim M; Department of Chemical and Biomolecular Engineering, Vanderbilt School of Engineering, Nashville, TN, 37232, USA., Haratipour Z; Austin Peay State University, 601 College St, Clarksville, TN 37044, USA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Orun AR; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., O'Rourke ML; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Oeser JK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Kim K; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 37232, USA., Claxton DP; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Blind RD; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA., Young JD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; Department of Chemical and Biomolecular Engineering, Vanderbilt School of Engineering, Nashville, TN, 37232, USA., O'Brien RM; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA. Electronic address: richard.obrien@vanderbilt.edu.

Publikováno v: Biochimie [Biochimie] 2024 Jul; Vol. 222, pp. 109-122. Date of Electronic Publication: 2024 Mar 01.

Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model.

Autor: Sinclair M; Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Stein RA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.; Center for Applied Artificial Intelligence in Protein Dynamics, Vanderbilt University, Nashville, TN 37240, USA., Sheehan JH; Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA., Hawes EM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., O'Brien RM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Tajkhorshid E; Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Claxton DP; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.; Center for Applied Artificial Intelligence in Protein Dynamics, Vanderbilt University, Nashville, TN 37240, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2024 Jan 29; Vol. 3 (2), pp. pgae036. Date of Electronic Publication: 2024 Jan 29 (Print Publication: 2024).

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.

Autor: Overway EM; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Bosma KJ; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Claxton DP; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Oeser JK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Singh K; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Breidenbach LB; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Davis LK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., O'Brien RM; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address: richard.obrien@vanderbilt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Feb; Vol. 298 (2), pp. 101534. Date of Electronic Publication: 2021 Dec 23.

Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters.

Autor: Claxton DP; Department of Molecular Physiology and Biophysics, Vanderbilt University, 747 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA., Jagessar KL; Department of Molecular Physiology and Biophysics, Vanderbilt University, 747 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA., Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University, 747 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: hassane.mchaourab@vanderbilt.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2021 Aug 06; Vol. 433 (16), pp. 166959. Date of Electronic Publication: 2021 Mar 24.

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy.

Autor: Han B; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Porta JC; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Hanks JL; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Peskova Y; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Binshtein E; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Dryden K; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Claxton DP; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Karakas E; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Ohi MD; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. mohi@umich.edu akk7hp@virginia.edu.; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Kenworthy AK; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA. mohi@umich.edu akk7hp@virginia.edu.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Publikováno v: Science advances [Sci Adv] 2020 Dec 02; Vol. 6 (49). Date of Electronic Publication: 2020 Dec 02 (Print Publication: 2020).