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CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches.

Autor: Tang J; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zheng Q; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Wang Q; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhao Y; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Ananthanarayanan P; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Reina C; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Šabanović B; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Jiang K; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Yang MH; Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan., Meny CC; 2(nd) Institute for Pathology and Experimental Oncology Research, Semmelweis University, 1085 Budapest, Hungary., Wang H; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Agerbaek MØ; Centre for Translational Medicine and Parasitology (CMP) at Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen N, Denmark; VarCT Diagnostics, Ole Maaloes vej 3, 2200 Copenhagen, Denmark., Clausen TM; Centre for Translational Medicine and Parasitology (CMP) at Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen N, Denmark., Gustavsson T; Centre for Translational Medicine and Parasitology (CMP) at Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen N, Denmark; VAR2Pharmaceuticals, Ole Maaloes vej 3, 2200 Copenhagen, Denmark., Wen C; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Borghi F; Department of Surgical Oncology, Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Mellano A; Department of Surgical Oncology, Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Fenocchio E; Department of Medical Oncology, Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Gregorc V; Department of Medical Oncology, Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Sapino A; Department of Pathology, Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy., Theander TG; Centre for Translational Medicine and Parasitology (CMP) at Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen N, Denmark., Fu D; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Aicher A; Precision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan; Immunology Research and Development Center, China Medical University, Taichung 404328, Taiwan., Salanti A; Centre for Translational Medicine and Parasitology (CMP) at Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen N, Denmark., Shen B; Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: shenby@shsmu.edu.cn., Heeschen C; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, 10060 Candiolo, Turin, Italy. Electronic address: christopher.heeschen@icloud.com.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Sep 17; Vol. 5 (9), pp. 101692. Date of Electronic Publication: 2024 Aug 19.

Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.

Autor: Vidal-Calvo EE; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. elena@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. elena@sund.ku.dk., Martin-Salazar A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Choudhary S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Dagil R; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Raghavan SSR; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Duvnjak L; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Nordmaj MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Clausen TM; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Skafte A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Oberkofler J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Wang K; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Agerbæk MØ; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Løppke C; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Jørgensen AM; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Ropac D; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Mujollari J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Willis S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Garcias López A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Karlsson RTG; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goerdeler F; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chen YH; GlycoDisplay ApS, Copenhagen, Denmark., Colaço AR; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wang Y; College of Life Sciences, Zhejiang University, Hangzhou, China., Lavstsen T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Martowicz A; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Nelepcu I; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Marzban M; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Oo HZ; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Ørum-Madsen MS; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Wang Y; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Nielsen MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Clausen H; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wierer M; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wolf D; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Gögenur I; Center for Surgical Science, Department of Surgery, Zealand University Hospital Køge, Køge, Denmark., Theander TG; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Al-Nakouzi N; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Gustavsson T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Daugaard M; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. mads.daugaard@ubc.ca.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. mads.daugaard@ubc.ca., Salanti A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. salanti@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. salanti@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 30; Vol. 15 (1), pp. 7553. Date of Electronic Publication: 2024 Aug 30.

Identification of global inhibitors of cellular glycosylation.

Autor: Sørensen DM; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Büll C; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.; Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University, 6525 AJ, Nijmegen, The Netherlands., Madsen TD; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Lira-Navarrete E; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.; The Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, 50018, Zaragoza, Spain.; Fundación ARAID, 50018, Zaragoza, Spain., Clausen TM; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.; John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Clark AE; Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Garretson AF; Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Karlsson R; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Pijnenborg JFA; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA., Miller RL; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA., Boltje TJ; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Schjoldager KT; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Vakhrushev SY; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Halim A; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Carlin AF; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Hurtado-Guerrero R; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.; The Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, 50018, Zaragoza, Spain.; Fundación ARAID, 50018, Zaragoza, Spain., Weigert R; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Clausen H; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. hclau@sund.ku.dk., Narimatsu Y; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. yoshiki@sund.ku.dk.; GlycoDisplay ApS, Copenhagen, Denmark. yoshiki@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 20; Vol. 14 (1), pp. 948. Date of Electronic Publication: 2023 Feb 20.

Spike-heparan sulfate interactions in SARS-CoV-2 infection.

Autor: Kearns FL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/fiona_chembot., Sandoval DR; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Casalino L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/LCasalino88., Clausen TM; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Rosenfeld MA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/mia_rosenfeld., Spliid CB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Amaro RE; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/RommieAmaro., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jesko@health.ucsd.edu.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2022 Oct; Vol. 76, pp. 102439. Date of Electronic Publication: 2022 Jul 06.