Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy: A Randomized Clinical Trial.

Autor: Bestle MH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-North Zealand, Hilleroed, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Stensballe J; Capital Region Blood Bank, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Anesthesiology and Trauma, Centre of Head and Ortopaedics, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Lange T; Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Clausen NE; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Søe-Jensen P; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Pedersen KH; Capital Region Blood Bank, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Gybel-Brask M; Capital Region Blood Bank, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Kjær MN; Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Steensen CO; Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Jensen DB; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Gärtner R; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Schønemann-Lund M; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-North Zealand, Hilleroed, Denmark., Kristiansen KT; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark., Lindhardt A; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Zealand University Hospital, Koege, Denmark., Johansson PI; Capital Region Blood Bank, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Perner A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.

Publikováno v: JAMA network open [JAMA Netw Open] 2024 Sep 03; Vol. 7 (9), pp. e2432444. Date of Electronic Publication: 2024 Sep 03.

Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU).

Autor: Anthon CT; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Pène F; Médecine Intensive and Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Cité, Paris, France., Perner A; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Médecine Intensive and Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France., Azoulay E; Médecine Intensive and Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France., Puxty K; Department of Intensive Care, Glasgow Royal Infirmary, Glasgow, UK., Van De Louw A; Division of Pulmonary and Critical Care, Penn State University College of Medicine, Hershey, PA, USA., Barratt-Due A; Department of Anaesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Chawla S; Critical Care Medicine Service, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA., Castro P; Medical Intensive Care Unit, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain., Póvoa P; Department of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal.; Nova Medical School, CHRC, New University of Lisbon, Lisbon, Portugal.; Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, Odense University Hospital, Odense, Denmark., Coelho L; Department of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal.; Nova Medical School, CHRC, New University of Lisbon, Lisbon, Portugal., Metaxa V; Department of Critical Care, King's College Hospital NHS Foundation Trust, London, UK., Kochanek M; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Liebregts T; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Kander T; Department of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden.; Department of Clinical Sciences, Lund University, Lund, Sweden., Hästbacka J; Department of Perioperative and Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Anaesthesiology and Intensive Care, Tampere University Hospital and Tampere University, Tampere, Finland., Andreasen JB; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Péju E; Médecine Intensive and Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Cité, Paris, France., Nielsen LB; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark., Hvas CL; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Dufranc E; Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Paris, France., Canet E; Médecine Intensive Réanimation, CHU de Nantes, Université de Nantes, Nantes, France., Lundqvist L; Department of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden., Wright CJ; Critical Care Unit, Elizabeth University Hospital, Glasgow, Queen, UK., Schmidt J; Service de Réanimation Médico-Chirurgicale, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France., Uhel F; Médecine Intensive Réanimation, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, DMU ESPRIT, Paris, France.; Institut Necker-Enfants Malades, Université Paris Cité, INSERMUMR-S1151, CNRSUMR-S8253, Paris, France., Ait-Oufella H; Service de Médecine Intensive-Réanimation, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France., Krag M; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Intensive Care, Holbaek Hospital, Holbaek, Denmark., Cos Badia E; Department of Intensive Care, Hospital General Granollers, Barcelona, Spain., Díaz-Lagares C; Intensive Care Department, Vall d'Hebron Hospital Universitari, Barcelona, Spain.; SODIR Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Menat S; Service de Médecine Intensive-Réanimation, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France., Voiriot G; Service de Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Centre de Recherche Saint-Antoine UMRS_938 INSERM, Paris, France., Clausen NE; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Lorentzen K; Department of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Kvåle R; Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.; Faculty of Medicine, University of Bergen, Bergen, Norway., Hildebrandt T; Department of Intensive Care, Zealand University Hospital - Roskilde, Roskilde, Denmark., Holten AR; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Strand K; Department of Intensive Care, Stavanger University Hospital, Stavanger, Norway., Tzalavras A; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Bestle MH; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark., Klepstad P; Department of Intensive Care Medicine, St. Olav's University Hospital, Trondheim, Norway.; Department Circulation and Medical Imaging, Norwegian University of Technology and Science, Trondheim, Norway., Fernandez S; Medical Intensive Care Unit, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Vimpere D; Médecine Intensive and Réanimation, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France., Paulino C; Nova Medical School, CHRC, New University of Lisbon, Lisbon, Portugal.; Department of Intensive Care, Hospital da Luz Lisboa, Lisbon, Portugal., Graça C; Department of Intensive Care, Hospital Central do Funchal, Funchal, Portugal., Lueck C; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Juhl CS; Department of Anaesthesiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Costa C; Intensive Care Unit, Hospital Professor Doutor Fernando Fonseca, EPE, Amadora, Portugal., Bådstøløkken PM; Department of Intensive Care B203, Akershus University Hospital, Lorenskog, Norway., Miranda T; Department of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal., Lêdo LSA; Department of Intensive Care Medicine-Unit 2, Hospital Egas Moniz-CHLO, EPE, Lisbon, Portugal., Sousa Torres JC; Department of Intensive Care Medicine-Unit 1, Hospital Egas Moniz-CHLO, EPE, Lisbon, Portugal., Granholm A; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Møller MH; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Russell L; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. lene.russell@mail.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. lene.russell@mail.dk.; Médecine Intensive and Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France. lene.russell@mail.dk.; Department of Intensive Care, Copenhagen University Hospital - Gentofte, Hellerup, Denmark. lene.russell@mail.dk.

Publikováno v: Intensive care medicine [Intensive Care Med] 2024 Jan; Vol. 50 (1), pp. 154-155.

The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection.

Autor: Vigstedt M; Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark. Electronic address: martin.vigstedt@regionh.dk., Søe-Jensen P; Department of Intensive Care, Herlev Hospital, Copenhagen, Denmark., Bestle MH; Department of Intensive Care, Copenhagen University Hospital - North Zealand, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Clausen NE; Department of Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark., Kristiansen KT; Department of Intensive Care, Hvidovre Hospital, Copenhagen, Denmark., Lange T; Department of Biostatistics, University of Copenhagen, Denmark., Stensballe J; Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark; Department of Anaesthesiology, Center of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark., Perner A; Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Johansson PI; Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Journal of critical care [J Crit Care] 2022 Jun; Vol. 69, pp. 154010. Date of Electronic Publication: 2022 Feb 17.

Prostacyclin in Intubated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized Clinical Trial.

Autor: Johansson PI; Department of Clinical Immunology.; Department of Clinical Medicine and., Søe-Jensen P; Department of Intensive Care, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Bestle MH; Department of Intensive Care, Copenhagen University Hospital-North Zealand, Copenhagen, Denmark.; Department of Clinical Medicine and., Clausen NE; Department of Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Kristiansen KT; Department of Intensive Care. Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark; and., Lange T; Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Stensballe J; Department of Clinical Immunology.; Department of Anaesthesiology, Center of Head and Orthopaedics., Perner A; Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine and.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Feb 01; Vol. 205 (3), pp. 324-329.

Efficacy and safety of iloprost in patients with septic shock-induced endotheliopathy-Protocol for the multicenter randomized, placebo-controlled, blinded, investigator-initiated trial.

Autor: Bestle MH; Department of Intensive Care, Nordsjaellands Hospital, Hillerod, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Clausen NE; Department of Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark., Søe-Jensen P; Department of Intensive Care, Herlev Hospital, Herlev, Denmark., Kristiansen KT; Department of Intensive Care, Hvidovre Hospital, Hvidovre, Denmark., Lange T; Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Johansson PI; Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark., Stensballe J; Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark.; Department of Anaesthesiology and Trauma, Centre of Head and Ortopaedics, Rigshospitalet, Copenhagen, Denmark., Perner A; Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark.

Publikováno v: Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2020 May; Vol. 64 (5), pp. 705-711. Date of Electronic Publication: 2020 Feb 03.