Výsledky vyhledávání - "Claus-Henning Nagel"

Akademický článek

Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo.

Autor: Julia S Czechowicz, Claus-Henning Nagel, Maike Voges, Michael Spohn, Martha M Eibl, Joachim Hauber

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0201880 (2018)

Herpes Simplex Virus type 2 (HSV-2) is a neurotropic human pathogen. Upon de novo infection, the viral infected cell protein 0 (ICP0) is immediately expressed and interacts with various cellular components during the viral replication cycle. ICP0 is

Externí odkaz: https://doaj.org/article/9e3aace9aca547289871f655255a221e

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Akademický článek

Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting.

Autor: Anna Buch, Oliver Müller, Lyudmila Ivanova, Katinka Döhner, Dagmara Bialy, Jens B Bosse, Anja Pohlmann, Anne Binz, Maike Hegemann, Claus-Henning Nagel, Martin Koltzenburg, Abel Viejo-Borbolla, Bodo Rosenhahn, Rudolf Bauerfeind, Beate Sodeik

Publikováno v: PLoS Pathogens, Vol 13, Iss 12, p e1006813 (2017)

Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid

Externí odkaz: https://doaj.org/article/7853ec5c48814a7b820f749a27354cd0

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Akademický článek

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.

Autor: Christina Funk, Melanie Ott, Verena Raschbichler, Claus-Henning Nagel, Anne Binz, Beate Sodeik, Rudolf Bauerfeind, Susanne M Bailer

Publikováno v: PLoS Pathogens, Vol 11, Iss 6, p e1004957 (2015)

Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of t

Externí odkaz: https://doaj.org/article/062ec7a02563460b9ba6588e79d855f3

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Akademický článek

A herpes simplex virus-derived replicative vector expressing LIF limits experimental demyelinating disease and modulates autoimmunity.

Autor: Michaela Nygårdas, Henrik Paavilainen, Nadine Müther, Claus-Henning Nagel, Matias Röyttä, Beate Sodeik, Veijo Hukkanen

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64200 (2013)

Herpes simplex virus type 1 (HSV-1) has properties that can be exploited for the development of gene therapy vectors. The neurotropism of HSV enables delivery of therapeutic genes to the nervous system. Using a bacterial artificial chromosome (BAC),

Externí odkaz: https://doaj.org/article/f68e157352fd47a3830a6bacbd134747

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Akademický článek

Improper tagging of the non-essential small capsid protein VP26 impairs nuclear capsid egress of herpes simplex virus.

Autor: Claus-Henning Nagel, Katinka Döhner, Anne Binz, Rudolf Bauerfeind, Beate Sodeik

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e44177 (2012)

To analyze the subcellular trafficking of herpesvirus capsids, the small capsid protein has been labeled with different fluorescent proteins. Here, we analyzed the infectivity of several HSV1(17(+)) strains in which the N-terminal region of the non-e

Externí odkaz: https://doaj.org/article/da6205618c52485b82a16495e0e3252d

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Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner

Autor: Sangar Srivaratharajan, Antonio Alcami, Abel Viejo-Borbolla, Katinka Döhner, Alberto Domingo López-Muñoz, Beate Sodeik, Birgit Ritter, Alberto Rastrojo, Akshay Dhingra, Claus-Henning Nagel, Kai A. Kropp, Rocío Martín, Julia S. Czechowicz

Publikováno v: Journal of Virology
Digital.CSIC. Repositorio Institucional del CSIC
instname

Herpes simplex virus 2 (HSV-2) is a prevalent human pathogen that establishes lifelong latency in neurons of the peripheral nervous system. Colonization of neurons is required for HSV-2 persistence and pathogenesis. The viral and cellular factors req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca4c1be83fa511e0a9c6b0fb529a0dc
https://pubmed.ncbi.nlm.nih.gov/32669337

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Biological Relevance and Therapeutic Potential of the Hypusine Modification System

Autor: Melanie Neumann, Henning Sievert, Claus-Henning Nagel, Michael Preukschas, Michaela Schweizer, Stefan Balabanov, Christian Hagel, Eugenia Haralambieva, Irm Hermans-Borgmeyer, Carsten Bokemeyer, Nora Pällmann, Peter J. Wild, Melanie Braig, Joachim Hauber

Publikováno v: Journal of Biological Chemistry. 290:18343-18360

Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial regulator in cancer, infections, and inflammation. Although its contribution in translational regulation of proline repeat-rich proteins has been sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fda458582d82310426d2e405348c78e
https://doi.org/10.1074/jbc.m115.664490

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Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting

Autor: Dagmara Bialy, Martin Koltzenburg, Oliver Müller, Beate Sodeik, Katinka Döhner, Jens B. Bosse, Bodo Rosenhahn, Maike Hegemann, Anne Binz, Rudolf Bauerfeind, Claus-Henning Nagel, Lyudmila Ivanova, Anja Pohlmann, Anna Buch, Abel Viejo-Borbolla

Publikováno v: PLoS Pathogens 13 (2017), Nr. 12
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 12, p e1006813 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cf400437d9a14cd559fb40d7ed689b
https://www.repo.uni-hannover.de/handle/123456789/5395

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Protein-protein-interaction Network Organization of the Hypusine Modification System

Autor: Reinhard Walther, Kent E. Duncan, Joachim Hauber, Martin Schaletzky, Ralf Pörtner, Oscar Platas-Barradas, Stefan Balabanov, Melanie Braig, Claus-Henning Nagel, Carsten Bokemeyer, Vishnu M. Dhople, Simone Venz, Nora Pällmann, Henning Sievert, Tim H. Brümmendorf, Michael Preukschas

Publikováno v: Molecular & cellular proteomics : MCP 11 (11): 1289-1305 (2012)
Molecular & Cellular Proteomics : MCP

Hypusine modification of eukaryotic initiation factor 5A (eIF-5A) represents a unique and highly specific post-translational modification with regulatory functions in cancer, diabetes, and infectious diseases. However, the specific cellular pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ae31ebc0a28b58a5fe895f18192889
https://doi.org/10.1074/mcp.m112.019059

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The C Terminus of the Large Tegument Protein pUL36 Contains Multiple Capsid Binding Sites That Function Differently during Assembly and Cell Entry of Herpes Simplex Virus

Autor: Anne Binz, Claus-Henning Nagel, Anja Pohlmann, Julia Schipke, Beate Sodeik, Rudolf Bauerfeind, Kathrin Rudolph, Randi Diestel

Publikováno v: Journal of Virology. 86:3682-3700

The largest tegument protein of herpes simplex virus type 1 (HSV1), pUL36, is a multivalent cross-linker between the viral capsids and the tegument and associated membrane proteins during assembly that upon subsequent cell entry releases the incoming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45635add5631f79da13ade7f70de9b0
https://doi.org/10.1128/jvi.06432-11

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