Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Claus Tornby Christoffersen"'
Autor:
Ralf Köhler, José María Abad Díez, Lars Kyhn Rasmussen, María D. Díaz-de-Villegas, Jan Kehler, Claus Tornby Christoffersen, Alejandro Castán, José A. Gálvez, Ramón Badorrey
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Two series of novel chiral hexahydro-2H-furo[3,2-b]pyrroles, 4-(7,8-dimethoxyquinazolin-4-yl) series A and 4-(6,7- dimethoxyquinazolin-4-yl) series B, were synthesized in enantiomerically pure form and evaluated for their inhibitory effects on phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04d1dd40bc2fd5623e30b52a4b5d555
http://hdl.handle.net/10261/220552
http://hdl.handle.net/10261/220552
Autor:
Oliver Griesbeck, Dahdjim Betolngar, Jan Kehler, Liliana R. V. Castro, Charlotte Hougaard, Pierre Vincent, Jun Yang, Élia Mota, Arne Fabritius, Claus Tornby Christoffersen, Jacob Nielsen
Publikováno v:
Cerebral Cortex
Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
The calcium-regulated phosphodiesterase 1 (PDE1) family is highly expressed in the brain, but its functional role in neurones is poorly understood. Using the selective PDE1 inhibitor Lu AF64196 and biosensors for cyclic nucleotides including a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58574bad650f7c419ae1faba3dcbb1
https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B
https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B
Autor:
Rasmus P. Clausen, Claus Tornby Christoffersen, Mauro Marigo, Karsten Juhl, Kasper Fjelbye, Erling B. Jørgensen
Publikováno v:
MedChemComm. 9:893-896
P-Glycoprotein (Pgp)-mediated cellular efflux is recognized as a common challenge in CNS drug discovery. In this study, the influence of replacing a hydrogen atom with fluorine on the pKa and Pgp-mediated efflux is elucidated for a series of PDE9 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc7ea26ebb78dfccd2c50f318b6e9408
https://doi.org/10.1039/c8md00114f
https://doi.org/10.1039/c8md00114f
Autor:
Jacob Nielsen, Thomas Dalsgaard, Dorte Clausen, Lasse Folkersen, Lars Kyhn Rasmussen, Makhala M. Khammy, Claus Tornby Christoffersen, Peter Hjørringgaard Larsen, Morten Grunnet, Jan Kehler, Christian Aalkjaer
Publikováno v:
British Journal of Pharmacology. 174:4186-4198
Background and Purpose PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed48d77c724ef4e0d3657e422ae2bcb
https://doi.org/10.1111/bph.14034
https://doi.org/10.1111/bph.14034
Autor:
Ulf Simonsen, Christoffer Bundgaard, Tomas Mow, Susie Mogensen, Estéfano Pinilla, Morten Grunnet, Jan Kehler, Morten Laursen, Claus Tornby Christoffersen, Lilliana Beck, Jakob S. Knudsen, Elise R. Hedegaard
Publikováno v:
British Journal of Pharmacology. 174:2563-2575
Background and purpose Phosphodiesterase enzymes (PDE1-11) break down cyclic nucleotides and are important in the regulation of the cardiovascular system. The purpose of the present study was to investigate the effect on the cardiovascular system of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd379087ddb01a34b9b4760977398c2
https://doi.org/10.1111/bph.13868
https://doi.org/10.1111/bph.13868
Autor:
Makhala Michell, Khammy, Thomas, Dalsgaard, Peter Hjørringgaard, Larsen, Claus Tornby, Christoffersen, Dorte, Clausen, Lars Kyhn, Rasmussen, Lasse, Folkersen, Morten, Grunnet, Jan, Kehler, Christian, Aalkjaer, Jacob, Nielsen
Publikováno v:
British journal of pharmacology. 174(22)
PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This study used isoform-preferri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d2d56b1897d8e6598073509726cd1e6
https://pubmed.ncbi.nlm.nih.gov/28910498
https://pubmed.ncbi.nlm.nih.gov/28910498
Asc-1 transporter regulation of synaptic activity via the tonic release of D-serine in the forebrain
Autor:
Hazem Safory, Eitan Kaplan, Jean-Marie Billard, Christoffer Bundgaard, Christian Thomsen, Avi Avital, Hagit Sason, Salman Zubedat, Samah Neame, Kenneth Vielsted Christensen, Dina Rosenberg, Claus Tornby Christoffersen, Garrick Paul Smith, Herman Wolosker, Veronika N. Foltyn
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩
d-Serine is a co-agonist of NMDA receptors (NMDARs) whose activity is potentially regulated by Asc-1 (SLC7A10), a transporter that displays high affinity for d-serine and glycine. Asc-1 operates as a facilitative transporter and as an antiporter, tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e811a43353d2e0dd0cbd67c9faf985c
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027
Autor:
Jacob Nielsen, Arne Mørk, Claus Tornby Christoffersen, Michael Didriksen, Thomas Werge, Peter H. Larsen, Dorte Clausen, Pekka Kallunki, Florence Sotty, Vibeke Nielsen, Kenneth Vielsted Christensen, Jan Egebjerg, Kim Fejgin, Jes B. Lauridsen, Leonid Yavich
Publikováno v:
Nielsen, J, Fejgin, K, Sotty, F, Nielsen, V, Mørk, A, Christoffersen, C T, Yavich, L, Lauridsen, J B, Clausen, D, Larsen, P H, Egebjerg, J, Werge, T M, Kallunki, P, Christensen, K V & Didriksen, M 2017, ' A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission ', Translational Psychiatry, vol. 7, 1261 . https://doi.org/10.1038/s41398-017-0011-8
Translational Psychiatry, Vol 7, Iss 11, Pp 1-12 (2017)
Translational Psychiatry
Translational Psychiatry, Vol 7, Iss 11, Pp 1-12 (2017)
Translational Psychiatry
1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model (Df(h1q21)/+) and characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88cec9bd5b427c9276fe6632f567c56
https://erepo.uef.fi/handle/123456789/5774
https://erepo.uef.fi/handle/123456789/5774
Autor:
Morten Langgård, Claus Tornby Christoffersen, Gérard Aimé Pinna, Battistina Asproni, Antonio Dore, Jan Kehler, Alessia Scampuddu
Publikováno v:
European Journal of Medicinal Chemistry. 84:181-193
Novel pyrazolo[5,1-f][1,6]naphthyridines, pyrazolo[5,1-a][2,6]naphthyridines, pyrazolo[5,1-a][2,7]naphthyridines and pyrazolo[5,1-a]isoquinolines phenylimidazole/benzimidazole ethylene-linked were designed and synthesized for PDE10A interaction. An A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa892d65afd61d6421377053d12d109
https://doi.org/10.1016/j.ejmech.2014.07.020
https://doi.org/10.1016/j.ejmech.2014.07.020
Autor:
Kasper Harpsøe, Claus Tornby Christoffersen, Jan Kehler, P. Brøsen, Niels Krogsgaard-Larsen, Thomas Balle
Publikováno v:
Neurochemical Research. 39:1997-2007
The scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that became the template for design and synthesis of dopamine D2 agonists during the following four d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9e333ceeecb19f3f918d0fc58b3c61
https://doi.org/10.1007/s11064-014-1314-2
https://doi.org/10.1007/s11064-014-1314-2