Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Claus Spitzfaden"'
Autor:
Eleonora Lekova, Wioleta M. Zelek, David Gower, Claus Spitzfaden, Isabelle H. Osuch, Elen John-Morris, Lasse Stach, Darren Gormley, Andrew Sanderson, Angela Bridges, Elizabeth R. Wear, Sebastien Petit-Frere, Michael N. Burden, Richard Priest, Trevor Wattam, Semra J. Kitchen, Maria Feeney, Susannah Davis, B. Paul Morgan, Eva-Maria Nichols
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Myasthenia Gravis (MG) is mediated by autoantibodies against acetylcholine receptors that cause loss of the receptors in the neuromuscular junction. Eculizumab, a C5-inhibitor, is the only approved treatment for MG that mechanistically addresses comp
Externí odkaz:
https://doaj.org/article/7143005e8ec646f3bc662008740e1e30
Autor:
Michael M. Hann, Claus Spitzfaden, Claudine Mayer, Alexandra Aubry, Alka Agrawal, Mélanie Roué, Stéphanie Petrella, Benjamin D. Bax
Publikováno v:
Biochemical Journal. 456:263-273
DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA duplex and transporting another DNA duplex [T-DNA (transported DNA)] through this break. The ATPase domains dimerize, in the presence of ATP, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f43c26c77cb631a175bbde22ead99b0
https://doi.org/10.1042/bj20130538
https://doi.org/10.1042/bj20130538
Autor:
Colin J. Suckling, Claus Spitzfaden, Andrew N. Hobbs, Craig Jamieson, Peter Francis, Robert J. Young, Ian Churcher, Sophie M. Bertrand, Ryan P. Bingham, Sarah E. Smith, Donald O. Somers, Nicolas Ancellin, Nerina Dodic, Paul S. Carter, Chun-wa Chung, Charlène Fournier, Jennifer A. Borthwick, Stephen D. Pickett
Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a combination of STD-NMR, thermal melt (Tm), and biochemical assays to identify compounds that bound t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019a009ff86efad911c0ace056f53ba5
https://strathprints.strath.ac.uk/55944/1/Borthwick_etal_JMC_2016_structurally_diverse_mitochondrial_branched_chain_aminotransferase_BCATm_leads_with_varying_binding_modes_identified_by_fragment_screening.pdf
https://strathprints.strath.ac.uk/55944/1/Borthwick_etal_JMC_2016_structurally_diverse_mitochondrial_branched_chain_aminotransferase_BCATm_leads_with_varying_binding_modes_identified_by_fragment_screening.pdf
Autor:
Michael N. Gwynn, Jianzhong Huang, Martin Hibbs, Claus Spitzfaden, Jason Pizzollo, Haifeng Cui, Velupillai Srikannathasan, Robert Tanner, Karen A. Ingraham, Robert A. Stavenger, Pan F. Chan, Minghua Gu, Carol Shen, Paul Homes, Andrew J. Theobald, Andrew P. Fosberry, Anthony Shillings, Michael M. Hann, Benjamin D. Bax
Publikováno v:
Nature Communications
New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by creating transient double-strand DNA breaks. Here we report the first co-crystal struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b4c3994d8361a48efe0cd59325b97
https://doi.org/10.1038/ncomms10048
https://doi.org/10.1038/ncomms10048
Autor:
Ian Churcher, Sarah E. Smith, Ryan P. Bingham, Clare I. Hobbs, Donald O. Somers, Eric Boursier, Chun Wa Chung, Charlène Fournier, Yoshiaki Washio, Peter Francis, Claus Spitzfaden, Iain H. Reid, Stephen D. Pickett, Sophie M. Bertrand, Graham L. Simpson, Andrew N. Hobbs, Klára Valkó, Laura A. Gummer, Robert J. Young, Nicolas Ancellin, Craig Jamieson, Colin J. Suckling, Anne Bénédicte Boullay, Lisa A. Sloan, Kenny Herry, Paul S. Carter, Nerina Dodic, Paul Homes, Edwige Nicodeme, Jennifer A. Borthwick, Benjamin Beaufils, Marie Helene Fouchet
Publikováno v:
Journal of medicinal chemistry. 58(18)
The hybridization of hits, identified by complementary fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-benzylamino-pyrazolo[1,5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce49f6995b13621d1b99ef02fe9002a
https://pubmed.ncbi.nlm.nih.gov/26339805
https://pubmed.ncbi.nlm.nih.gov/26339805
Autor:
Claus Spitzfaden, Paul Homes, Andrew P. Fosberry, Jianzhong Huang, Martin Hibbs, Michael N. Gwynn, Anthony Shillings, Alexandre Wohlkonig, Andrew J. Theobald, Pan F. Chan, Velupillai Srikannathasan, Onkar M. P. Singh, Benjamin D. Bax
Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10eeb8df12cca74374d1610c9aeae7
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
Autor:
Harry John Wadsworth, Fiona Godfrey, Claus Spitzfaden, Stephen J. Wood, Kevin H. Jennings, Amanda E. Perry, Roger Edward Markwell, Jane E. Swatton, David R. Howlett
Publikováno v:
Biochemical Journal. 340:283-289
A series of benzofuran derivatives have been identified as inhibitors of fibril formation in the β-amyloid peptide. The activity of these compounds has been assessed by a novel fibril-formation-specific immunoassay and for their effects on the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49c2883d557da0fe9d17efd76b1de2c
https://doi.org/10.1042/bj3400283
https://doi.org/10.1042/bj3400283
Publikováno v:
Journal of Molecular Biology. 270:763-770
The homologous ninth and tenth type III modules of human fibronectin share identical topologies and nearly identical core structures. Despite these structural similarities, the refolding characteristics of the two modules, which have a sequence ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670337191776b27a47f6ac000a0e3da3
https://doi.org/10.1006/jmbi.1997.1148
https://doi.org/10.1006/jmbi.1997.1148
Publikováno v:
Journal of Biological Chemistry. 272:6159-6166
The ninth and tenth type III domains of fibronectin each contain specific cell binding sequences, RGD in FIII10 and PHSRN in FIII9, that act synergistically in mediating cell adhesion. We investigated the relationship between domain-domain orientatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76effeda15da9abddd92e4ceefed874
https://doi.org/10.1074/jbc.272.10.6159
https://doi.org/10.1074/jbc.272.10.6159
Publikováno v:
Journal of Molecular Biology. 265:565-579
The structure of mosaic proteins depends on the nature and strength of interactions between individual modules. Here we investigated the structural significance of module-module interactions in the RGD-depen dent cell binding region of human fibronec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c271a7d830eaf5c330d272602ca5954c
https://doi.org/10.1006/jmbi.1996.0736
https://doi.org/10.1006/jmbi.1996.0736