Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Claus Pietrzik"'
Autor:
Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidoly
Externí odkaz:
https://doaj.org/article/bf1fc4064fa54fe8be2da48d70db411d
Autor:
Jae Yoon Leem, Carlos A. Saura, Claus Pietrzik, John Christianson, Christian Wanamaker, LaShaunda T. King, Margaret L. Veselits, Taisuke Tomita, Laura Gasparini, Takeshi Iwatsubo, Huaxi Xu, William N. Green, Edward H. Koo, Gopal Thinakaran
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 64-82 (2002)
Presenilin 1 (PS1) and presenilin 2 play a critical role in the γ-secretase processing of amyloid precursor protein (APP) and Notch1. Here, we investigate maturation and intracellular trafficking of APP and other membrane proteins in cells expressin
Externí odkaz:
https://doaj.org/article/23c00155a55149cd91c9be2554087fe7
Autor:
Naira P Martínez Vera, Reinhold Schmidt, Klaus Langer, Iavor Zlatev, Robert Wronski, Ewald Auer, Daniel Havas, Manfred Windisch, Hagen von Briesen, Sylvia Wagner, Julia Stab, Motti Deutsch, Claus Pietrzik, Franz Fazekas, Stefan Ropele
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92068 (2014)
This study was performed to explore the feasibility of tracing nanoparticles for drug transport in the healthy rat brain with a clinical MRI scanner. Phantom studies were performed to assess the R1 ( = 1/T1) relaxivity of different magnetically label
Externí odkaz:
https://doaj.org/article/d4e3429bf71e4b1b9db56514734a1b24
Autor:
Grace Png, Raffaele Gerlini, Konstantinos Hatzikotoulas, Andrei Barysenka, N William Rayner, Lucija Klarić, Birgit Rathkolb, Juan A Aguilar-Pimentel, Jan Rozman, Helmut Fuchs, Valerie Gailus-Durner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Claus Pietrzik, James F Wilson, Martin Hrabe de Angelis, Christoph Becker-Pauly, Arthur Gilly, Eleftheria Zeggini
Publikováno v:
Hum. Mol. Genet., DOI: 10.1093/hmg/ddac275 (2022)
Png, G, Gerlini, R, Hatzikotoulas, K, Barysenka, A, Rayner, N W, Klarić, L, Rathkolb, B, Aguilar-Pimentel, J A, Rozman, J, Fuchs, H, Gailus-Durner, V, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Pietrzik, C, Wilson, J F, Angelis, M H, Becker-Pauly, C, Gilly, A & Zeggini, E 2022, ' Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac275
Png, G, Gerlini, R, Hatzikotoulas, K, Barysenka, A, Rayner, N W, Klarić, L, Rathkolb, B, Aguilar-Pimentel, J A, Rozman, J, Fuchs, H, Gailus-Durner, V, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Pietrzik, C, Wilson, J F, Angelis, M H, Becker-Pauly, C, Gilly, A & Zeggini, E 2022, ' Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac275
Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high public health burden. Understanding the genetically determined regulation of proteins that are dysregulated in disease can help to dissect the complex biology u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f316b3891f3dbb04c249127652ce7a
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66664
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66664
Autor:
Steffen Storck, Claus Pietrzik
The entry of blood-borne molecules into the brain is restricted by the blood brain-barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0259282d03f84de2b416637623a24a8
https://doi.org/10.21203/rs.3.rs-233246/v1
https://doi.org/10.21203/rs.3.rs-233246/v1
Autor:
Claus, Pietrzik, Christian, Behl
Publikováno v:
International journal of experimental pathology. 86(3)
To date, various strategies have been developed in order to prevent or to slow down the progression of Alzheimer's disease (AD). Despite the medical need for an effective therapeutic treatment of AD, progress towards this goal is painstakingly slow.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6457cd7f010d994099fb94eef5dfcee
https://pubmed.ncbi.nlm.nih.gov/15910551
https://pubmed.ncbi.nlm.nih.gov/15910551