ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol

Autor: Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)

Abstract Background Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue.

Externí odkaz: https://doaj.org/article/a0a91910609c4671b33a0c05325c0a1c

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Autor: Anne Louise Højmark Bisgaard, Carsten Brink, Maja Lynge Fransen, Tine Schytte, Claus P. Behrens, Ivan Vogelius, Henrik Dahl Nissen, Faisal Mahmood

Publikováno v: Physics and Imaging in Radiation Oncology, Vol 21, Iss , Pp 146-152 (2022)

Background and purpose: Diffusion-Weighted Magnetic Resonance imaging (DWI) quantifies water mobility through the Apparent Diffusion Coefficient (ADC), a promising radiotherapy response biomarker. ADC measurements depend on manual delineation of a re

Externí odkaz: https://doaj.org/article/2d42492020634609a01cca93b877a160

Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer

Autor: Astrid Zedlitz Johansen, Marco Carretta, Marie-Louise Thorseth, Shawez Khan, Klaire Yixin Fjæstad, Christian Beltoft Brøchner, Hannes Linder, Christina Ankjærgaard, Marco Donia, Inna Chen, Dorte Lisbet Nielsen, Claus Preibisch Behrens, Daniel Hargbøl Madsen

Publikováno v: Pharmaceutics, Vol 14, Iss 5, p 1046 (2022)

YKL-40 (also named chitinase 3 like-1 protein [CHI3L1]) is a secreted chitinase-like protein which is upregulated in cancers and suggested to have pro-tumorigenic activity. YKL-40 lacks enzymatic function, but it can bind carbohydrates such as chitin

Externí odkaz: https://doaj.org/article/78186d8268bd442d8ea8f1b9fe7ac71e

Online adaptive radiotherapy of urinary bladder cancer with full re-optimization to the anatomy of the day:initial experience and dosimetric benefits

Autor: Lina M. Åström, Claus P. Behrens, Lucie Calmels, David Sjöström, Poul Geertsen, Lene Sonne Mouritsen, Eva Serup-Hansen, Henriette Lindberg, Patrik Sibolt

Publikováno v: Åström, L M, Behrens, C P, Calmels, L, Sjöström, D, Geertsen, P, Mouritsen, L S, Serup-Hansen, E, Lindberg, H & Sibolt, P 2022, ' Online adaptive radiotherapy of urinary bladder cancer with full re-optimization to the anatomy of the day : initial experience and dosimetric benefits ', Radiotherapy and Oncology, vol. 171, pp. 37-42 . https://doi.org/10.1016/j.radonc.2022.03.014

Background and purpose: Online adaptive radiotherapy (oART) potentially reduces the dose to organs at risk (OARs) as the planning target volume (PTV) margins are reduced compared to a nonadaptive approach (non-ART). This study evaluates the feasibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facf8eafe789387320a3a8157a4144f0
https://orbit.dtu.dk/en/publications/e34f43b4-b88f-49d5-b3dc-df0dc7efecc3

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Autor: Anne Louise Højmark Bisgaard, Carsten Brink, Maja Lynge Fransen, Tine Schytte, Claus P. Behrens, Ivan Vogelius, Henrik Dahl Nissen, Faisal Mahmood

Publikováno v: Bisgaard, A L H, Brink, C, Fransen, M L, Schytte, T, Behrens, C P, Vogelius, I, Nissen, H D & Mahmood, F 2022, ' Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation ', Physics and Imaging in Radiation Oncology, vol. 21, pp. 146-152 . https://doi.org/10.1016/j.phro.2022.02.014
Bisgaard, A L H, Brink, C, Fransen, M L, Schytte, T, Behrens, C F, Vogelius, I R, Nissen, H D & Mahmood, F 2022, ' Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation ', Physics and Imaging in Radiation Oncology, vol. 21, pp. 146-152 . https://doi.org/10.1016/j.phro.2022.02.014

Background and purposeDiffusion-Weighted Magnetic Resonance imaging (DWI) quantifies water mobility through the Apparent Diffusion Coefficient (ADC), a promising radiotherapy response biomarker. ADC measurements depend on manual delineation of a regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57b167191372cf5c1b8b175ba97626c
https://pubmed.ncbi.nlm.nih.gov/35284662