Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Claus Nerlov"'
Autor:
Sophia Engelhard, Montserrat Estruch, Shuyu Qin, Christoph A. Engelhard, Francisco G. Rodriguez-Gonzalez, Martine Drilsvik, Javier Martin-Gonzalez, Jeng-Wei Lu, David Bryder, Claus Nerlov, Joachim Weischenfeldt, Kristian Reckzeh, Kim Theilgaard-Mönch
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114475- (2024)
Summary: Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lin
Externí odkaz:
https://doaj.org/article/3dfc405563e042acaabd1378d8d20651
Autor:
Alexandre Fagnan, Zakia Aid, Marie Baille, Aneta Drakul, Elie Robert, Cécile K. Lopez, Cécile Thirant, Yann Lecluse, Julie Rivière, Cathy Ignacimouttou, Silvia Salmoiraghi, Eduardo Anguita, Audrey Naimo, Christophe Marzac, Françoise Pflumio, Sébastien Malinge, Christian Wichmann, Yun Huang, Camille Lobry, Julie Chaumeil, Eric Soler, Jean‐Pierre Bourquin, Claus Nerlov, Olivier A. Bernard, Juerg Schwaller, Thomas Mercher
Publikováno v:
HemaSphere, Vol 8, Iss 6, Pp n/a-n/a (2024)
Abstract Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled E
Externí odkaz:
https://doaj.org/article/03efbfad1704429ab5fd121446f5b220
Autor:
Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A. Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C. Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J. Robson, Randy D. Blakely, Adam J. Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W. Jacobsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback
Externí odkaz:
https://doaj.org/article/45c592524cf44d3ebb3a8722a44142e6
Autor:
Edyta E. Wojtowicz, Jayna J. Mistry, Vladimir Uzun, Charlotte Hellmich, Anita Scoones, Desmond W. Chin, Laura M. Kettyle, Francesca Grasso, Allegra M. Lord, David J. Wright, Graham J. Etherington, Petter S. Woll, Mirjam E. Belderbos, Kristian M. Bowles, Claus Nerlov, Wilfried Haerty, Leonid V. Bystrykh, Sten Eirik W. Jacobsen, Stuart A. Rushworth, Iain C. Macaulay
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Background Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. Results We use lentiviral genetic labeling of mou
Externí odkaz:
https://doaj.org/article/1e471c0563ff42f9a6e250e9ee8b4611
Publikováno v:
HemaSphere, Vol 7, p e8112156 (2023)
Externí odkaz:
https://doaj.org/article/9cea260f7f0d46bfae5c901559ba3d7d
Autor:
Simona Valletta, Alexander Thomas, Yiran Meng, Xiying Ren, Roy Drissen, Hilal Sengül, Cristina Di Genua, Claus Nerlov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoiet
Externí odkaz:
https://doaj.org/article/d92c05c8ae8e4f60abab394fce4e0c0b
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-depen
Externí odkaz:
https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Curtiss, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c3c2338ac9144f60aac72e27a406a213
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a ro
Externí odkaz:
https://doaj.org/article/bcdccb1f096148578c444773d7337813
Autor:
Cristina Di Genua, Ruggiero Norfo, Alba Rodriguez-Meira, Wei Xiong Wen, Roy Drissen, Christopher A.G. Booth, Benjamin Povinelli, Emmanouela Repapi, Nicki Gray, Joana Carrelha, Laura M. Kettyle, Lauren Jamieson, Wen Hao Neo, Supat Thongjuea, Claus Nerlov, Adam J. Mead
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell (HSC) compartment, while signaling pathway
Externí odkaz:
https://doaj.org/article/63c14c0940654124844eb28a1e97c816