Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Claus Lindbjerg Andersen"'
Publikováno v:
The Lancet Regional Health. Europe, Vol 47, Iss , Pp 101093- (2024)
Summary: Background: The incidence of colorectal cancer (CRC) in individuals younger than 50 years of age (early-onset CRC) is increasing. Early-onset CRC often present at advanced stage, suggesting a more aggressive cancer course compared to late-on
Externí odkaz:
https://doaj.org/article/9e18131120ca402295220b45464c01d6
Autor:
Amanda Frydendahl, Mads Heilskov Rasmussen, Sarah Østrup Jensen, Tenna Vesterman Henriksen, Christina Demuth, Mathilde Diekema, Henrik Jørn Ditzel, Sara Witting Christensen Wen, Jakob Skou Pedersen, Lars Dyrskjøt, Claus Lindbjerg Andersen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4252 (2024)
Circulating tumor DNA (ctDNA) is a promising biomarker, reflecting the presence of tumor cells. Sequencing-based detection of ctDNA at low tumor fractions is challenging due to the crude error rate of sequencing. To mitigate this challenge, we develo
Externí odkaz:
https://doaj.org/article/f0e8dc6688e6430d80d24522c8c8ca28
Autor:
Victor E Velculescu, Gerrit A Meijer, Peter B Bach, Jamie E Medina, Nicholas C Dracopoli, Anna Lau, Robert B Scharpf, Claus Lindbjerg Andersen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Rapid advancements in the area of early cancer detection have brought us closer to achieving the goals of finding cancer early enough to treat or cure it, while avoiding harms of overdiagnosis. We evaluate progress in the development of early cancer
Externí odkaz:
https://doaj.org/article/8a3871bd88f74ac89f56f9ee74a059dd
Autor:
Tenna Vesterman Henriksen, Thomas Reinert, Mads Heilskov Rasmussen, Christina Demuth, Uffe Schou Løve, Anders Husted Madsen, Kåre Andersson Gotschalck, Lene Hjerrild Iversen, Claus Lindbjerg Andersen
Publikováno v:
Molecular Oncology, Vol 16, Iss 20, Pp 3654-3665 (2022)
Circulating tumour DNA (ctDNA) detection for postoperative risk stratification in cancer patients has great clinical potential. However, low ctDNA abundances complicates detection. Multitarget (MT) detection strategies have been developed to increase
Externí odkaz:
https://doaj.org/article/e7eb84fa40c94606a7b732033305c0d1
Autor:
Laia Simó-Riudalbas, Sandra Offner, Evarist Planet, Julien Duc, Laurence Abrami, Sagane Dind, Alexandre Coudray, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Claus Lindbjerg Andersen, Jesper Bertram Bramsen, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, the authors characterise cancer-specific transposable element-driven transpochimeric gene transcripts and highlight the role of POU5F1B in CRC grow
Externí odkaz:
https://doaj.org/article/a38569d1cb844be0bc2d549b4ade75f9
Autor:
Martín Santamarina-García, Jenifer Brea-Iglesias, Jesper Bertram Bramsen, Mar Fuentes-Losada, Francisco Javier Caneiro-Gómez, José Ángel Vázquez-Bueno, Héctor Lázare-Iglesias, Natalia Fernández-Díaz, Laura Sánchez-Rivadulla, Yoel Z. Betancor, Miriam Ferreiro-Pantín, Pablo Conesa-Zamora, José Ramón Antúnez-López, Masahito Kawazu, Manel Esteller, Claus Lindbjerg Andersen, Jose M.C. Tubio, Rafael López-López, Juan Ruiz-Bañobre
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106127- (2023)
Summary: Deficiency in DNA MMR activity results in tumors with a hypermutator phenotype, termed microsatellite instability (MSI). Beyond its utility in Lynch syndrome screening algorithms, today MSI has gained importance as predictive biomarker for v
Externí odkaz:
https://doaj.org/article/83da6a3eac0640c8b90364fbec5aee49
Autor:
Dimitrios Mathios, Jakob Sidenius Johansen, Stephen Cristiano, Jamie E. Medina, Jillian Phallen, Klaus R. Larsen, Daniel C. Bruhm, Noushin Niknafs, Leonardo Ferreira, Vilmos Adleff, Jia Yuee Chiao, Alessandro Leal, Michael Noe, James R. White, Adith S. Arun, Carolyn Hruban, Akshaya V. Annapragada, Sarah Østrup Jensen, Mai-Britt Worm Ørntoft, Anders Husted Madsen, Beatriz Carvalho, Meike de Wit, Jacob Carey, Nicholas C. Dracopoli, Tara Maddala, Kenneth C. Fang, Anne-Renee Hartman, Patrick M. Forde, Valsamo Anagnostou, Julie R. Brahmer, Remond J. A. Fijneman, Hans Jørgen Nielsen, Gerrit A. Meijer, Claus Lindbjerg Andersen, Anders Mellemgaard, Stig E. Bojesen, Robert B. Scharpf, Victor E. Velculescu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung
Externí odkaz:
https://doaj.org/article/fce9b8c82ce14c3ea1c846a1133812f2
Autor:
Gabriel Renaud, Maibritt Nørgaard, Johan Lindberg, Henrik Grönberg, Bram De Laere, Jørgen Bjerggaard Jensen, Michael Borre, Claus Lindbjerg Andersen, Karina Dalsgaard Sørensen, Lasse Maretty, Søren Besenbacher
Publikováno v:
eLife, Vol 11 (2022)
Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-mutational alterations. Recent work has shown that the length distribution of cfDNA fragments from a cancer patient can inform tumor
Externí odkaz:
https://doaj.org/article/e14d113e4d2845209c264adbdcb21fe7
Autor:
Jonas Kabel, Tenna Vesterman Henriksen, Christina Demuth, Amanda Frydendahl, Mads Heilskov Rasmussen, Jesper Nors, Nicolai J. Birkbak, Anders Husted Madsen, Uffe S. Løve, Per Vadgaard Andersen, Thomas Kolbro, Alessio Monti, Ole Thorlacius-Ussing, Mikail Gögenur, Jeppe Kildsig, Nis Hallundbæk Schlesinger, Peter Bondeven, Lene Hjerrild Iversen, Kåre Andersson Gotschalck, Claus Lindbjerg Andersen
Publikováno v:
Cancers, Vol 15, Iss 4, p 1136 (2023)
Objective: Circulating tumor DNA (ctDNA) is a candidate biomarker of cancer with practice-changing potential in the detection of both early and residual disease. Disease stage and tumor size affect the probability of ctDNA detection, whereas little i
Externí odkaz:
https://doaj.org/article/3db263193a9e4a52b8612dbf7384a127
Autor:
Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, Michael Knudsen, Maria Bach Laursen, Anders Husted Madsen, Lene Hjerrild Iversen, Kåre Gotschalck Sunesen, Mads Heilskov Rasmussen, Claus Lindbjerg Andersen
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemother
Externí odkaz:
https://doaj.org/article/90060eda57db48bc8f45e239d40eccb9