Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Claus J Loland"'
Publikováno v:
eLife, Vol 12 (2024)
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+ (Na1) contributes to the substrate binding, while the other Na+ (Na2) is tho
Externí odkaz:
https://doaj.org/article/b541b07cee2b4b2bb93fdbec258eadb3
Autor:
Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann Larsen, Jonas Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland
Publikováno v:
eLife, Vol 6 (2017)
The Neurotransmitter:Sodium Symporters (NSSs) represent an important class of proteins mediating sodium-dependent uptake of neurotransmitters from the extracellular space. The substrate binding stoichiometry of the bacterial NSS protein, LeuT, and th
Externí odkaz:
https://doaj.org/article/51197552729d4cf781d60eb7e00faffe
Autor:
Azmat Sohail, Kumaresan Jayaraman, Santhoshkannan Venkatesan, Kamil Gotfryd, Markus Daerr, Ulrik Gether, Claus J Loland, Klaus T Wanner, Michael Freissmuth, Harald H Sitte, Walter Sandtner, Thomas Stockner
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005197 (2016)
Human neurotransmitter transporters are found in the nervous system terminating synaptic signals by rapid removal of neurotransmitter molecules from the synaptic cleft. The homologous transporter LeuT, found in Aquifex aeolicus, was crystallized in d
Externí odkaz:
https://doaj.org/article/df1deda31b4c4be3b4346ef9e659d1d0
Autor:
Solveig G. Schmidt, Mette Galsgaard Malle, Anne Kathrine Nielsen, Søren S.-R. Bohr, Ciara F. Pugh, Jeppe C. Nielsen, Ida H. Poulsen, Kasper D. Rand, Nikos S. Hatzakis, Claus J. Loland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clear
Externí odkaz:
https://doaj.org/article/639e6c6d3fb94ff895a426dc699efbb4
Autor:
Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and obse
Externí odkaz:
https://doaj.org/article/7e4dd1b8938f4697aed6a531fb670e57
Autor:
Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for
Externí odkaz:
https://doaj.org/article/4706c23f56b542ffad3d502b3f12fe7e
Autor:
Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conforma
Externí odkaz:
https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
Autor:
Anne Kathrine Nielsen, Ingvar R. Möller, Yong Wang, Søren G. F. Rasmussen, Kresten Lindorff-Larsen, Kasper D. Rand, Claus J. Loland
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-ind
Externí odkaz:
https://doaj.org/article/029ceb9db51c4981be407b2faa05bd7d
Autor:
Ingvar R. Möller, Marika Slivacka, Anne Kathrine Nielsen, Søren G. F. Rasmussen, Ulrik Gether, Claus J. Loland, Kasper D. Rand
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dyna
Externí odkaz:
https://doaj.org/article/0eff74681cb349509bf0274d56961747
Autor:
Hazrat Hussain, Jonas S. Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J. Loland, Lan Guan, Brian K. Kobilka, Bernadette Byrne, Pil Seok Chae
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membrane
Externí odkaz:
https://doaj.org/article/087002c5c6c2415c9ebf4a39ab6e0c4d