Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Claus Bornæs"'
Autor:
Cathrine K. Fog, Paola Zago, Erika Malini, Lukasz M. Solanko, Paolo Peruzzo, Claus Bornaes, Raffaella Magnoni, Arnela Mehmedbasic, Nikolaj H.T. Petersen, Bruno Bembi, Johannes F.M.G. Aerts, Andrea Dardis, Thomas Kirkegaard
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 142-153 (2018)
Background: Gaucher Disease is caused by mutations of the GBA gene which encodes the lysosomal enzyme acid beta-glucosidase (GCase). GBA mutations commonly affect GCase function by perturbing its protein homeostasis rather than its catalytic activity
Externí odkaz:
https://doaj.org/article/73a0c1f67b9c4c39af175f9198dbb0e8
Autor:
Lukasz Michael Solanko, Paola Zago, Thomas Kirkegaard, Arnela Mehmedbasic, Andrea Dardis, Paolo Peruzzo, Claus Bornæs, Bruno Bembi, Johannes F.M.G. Aerts, Cathrine K. Fog, Erika Malini, Raffaella Magnoni, Nikolaj H.T. Petersen
Publikováno v:
EBioMedicine
EBioMedicine, 38, 142-153
EBioMedicine, 38, 142-153
Background Gaucher Disease is caused by mutations of the GBA gene which encodes the lysosomal enzyme acid beta-glucosidase (GCase). GBA mutations commonly affect GCase function by perturbing its protein homeostasis rather than its catalytic activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ea87fc92fe3eb2578318a7059e73fc
https://hdl.handle.net/1887/68305
https://hdl.handle.net/1887/68305
Autor:
Claus Bornæs, Nikolaj H.T. Petersen, Cathrine Kolster Fog-Tonnesen, Thomas Kirkegaard, Andrea Dardis, Lukasz Michael Solanko, Raffaella Magnoni, Erika Malini, Paolo Peruzzo, Bruno Bembi, Paola Zago
Gaucher Disease (GD) is caused by mutations of the GBA gene which encodes the lysosomal enzyme acid beta-glucosidase (GCase). GBA mutations commonly affect GCase function by perturbing its protein homeostasis rather than its catalytic activity. Heat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3401af6c1f6cbf89f126be08216f0f7c
Autor:
Frances M. Platt, Claus Bornæs, Christoph Arenz, Svetlana Drndarski, Ole Dines Olsen, James Gray, Thomas Kirkegaard, David J. Begley, Nikolaj H.T. Petersen, Marja Jäättelä, Linda Ingemann, Alexander Klein, David A. Priestman, David Smith, Anders Mørkeberg Hinsby, Kerri-Lee Wallom, Jennifer Atkins, Signe Humle Jørgensen
Lysosomal diseases often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We recently demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a29989410adc57d6fdf53ea7181920
https://ora.ox.ac.uk/objects/uuid:4ac3bf8e-231c-4e41-9f8c-90172d2dcde0
https://ora.ox.ac.uk/objects/uuid:4ac3bf8e-231c-4e41-9f8c-90172d2dcde0
Publikováno v:
Pharmaceutical research. 22(6)
Therapeutic proteins may induce antibodies that inhibit their efficacy or have other serious biological effects. There is a great need for strategies to predict whether a certain formulation will induce an immune response. In principle, conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ee0b63a18d4fcf6cad4b3a2a12dd85
https://pubmed.ncbi.nlm.nih.gov/15948027
https://pubmed.ncbi.nlm.nih.gov/15948027
Publikováno v:
Pharmaceutical Research; Jun2005, Vol. 22 Issue 6, p847-851, 5p
Autor:
Steen Holmberg, Claus Bornaes, Morten C. Kielland-Brandt, Torsten Nilsson-Tillgren, Jens G. Litske Petersen
Publikováno v:
Europe PubMed Central
The catabolic L-serine (L-threonine) deaminase of Saccharomyces cerevisiae allows the yeast to grow on media with L-serine or L-threonine as sole nitrogen source. A mutant, cha1 (catabolism of hydroxyamino acids), lacking this enzyme activity has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a32278a132670525ad777c820626f26
https://europepmc.org/articles/PMC1203438/
https://europepmc.org/articles/PMC1203438/
Autor:
Linda Ingemann, Frances M. Platt, James Gray, Thomas Kirkegaard, Signe Humle Jørgensen, Svetlana Drndarski, Ian D. Williams, David J. Begley, Christoph Arenz, Kerri-Lee Wallom, David Smith, Jennifer Atkins, David A. Priestman, Anders Mørkeberg Hinsby, Lauren Morris, Nikolaj H.T. Petersen, Claus Bornæs, Alexander Klein, Ole Dines Olsen, Marja Jäättelä
Publikováno v:
Science translational medicine. 8(355)
Lysosomal storage diseases (LSDs) often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfc6fcb3ac51bde9b4bce3bb65a2a09
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
DeWeerdt, Sarah
Publikováno v:
Nature; 9/22/2016 Supplement, Vol. 537 Issue 7621, pS154-S157, 4p, 3 Color Photographs
Autor:
Kirkegaard, Thomas, Gray, James, Priestman, David A., Wallom, Kerri-Lee, Atkins, Jennifer, Olsen, Ole Dines, Klein, Alexander, Drndarski, Svetlana, Petersen, Nikolaj H. T., Ingemann, Linda, Smith, David A., Morris, Lauren, Bornæs, Claus, Jørgensen, Signe Humle, Williams, Ian, Hinsby, Anders, Arenz, Christoph, Begley, David, Jäättelä, Marja, Platt, Frances M.
Publikováno v:
Science Translational Medicine; 9/7/2016, Vol. 8 Issue 355, p1-16, 16p, 1 Chart, 6 Graphs