Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Claus, Bruehl"'
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106306- (2023)
Glial glutamate transporters actively participate in neurotransmission and have a fundamental role in determining the ambient glutamate concentration in the extracellular space. Their expression is dynamically regulated in many diseases, including ex
Externí odkaz:
https://doaj.org/article/f35af09855c943a0a6aee17ddaa4358f
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Pessah Yampolsky, Michael Koenen, Matias Mosqueira, Pascal Geschwill, Sebastian Nauck, Monika Witzenberger, Claudia Seyler, Thomas Fink, Mathieu Kruska, Claus Bruehl, Alexander P. Schwoerer, Heimo Ehmke, Rainer H. A. Fink, Andreas Draguhn, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice an
Externí odkaz:
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
Autor:
Pascal Geschwill, Isabel Weigl, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer, Farbod Sedaghat-Hamedani, Claus Bruehl, Miriam Reiss, Michael Koenen, Andreas Draguhn, Benjamin Meder
Publikováno v:
Biochemical and Biophysical Research Communications
Atrial fibrillation (AF) is the most frequent sustained arrhythmia and can lead to structural cardiac changes, known as tachycardia-induced cardiomyopathy (TIC). HCN4 is implicated in spontaneous excitation of the sinoatrial node, while channel dysfu
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Hugo A. Katus, Matias Mosqueira, Pascal Geschwill, Claudia Seyler, Rainer H. A. Fink, Dierk Thomas, Pessah Yampolsky, Monika Witzenberger, Michael Koenen, Thomas Fink, Patrick A. Schweizer, Mathieu Kruska, Sebastian Nauck, Claus Bruehl, Andreas Draguhn, Heimo Ehmke, Alexander P. Schwoerer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
HCN channels underlie the depolarizing funny current (If) that contributes importantly to cardiac pacemaking. If is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mi
Autor:
Patrick Lugenbiel, Claus Bruehl, Hugo A. Katus, Ann-Kathrin Rahm, Pascal Syren, Norbert Frey, Dierk Thomas, Patrick A. Schweizer
Publikováno v:
Life sciences. 281
Aims Heart failure (HF) is linked to electrical remodeling that promotes ventricular arrhythmias. Underlying molecular signaling is insufficiently understood, in particular concerning patients with early disease stages. Previous observations suggest
Autor:
Dierk Thomas, Claus Bruehl, Katharina Govorov, Patrick Most, Nadine Weiberg, Tanja Weis, Maximilian N Wunsch, Patrick A. Schweizer, Emili Manolova, Rasmus Rivinius, Tanja Heimberger, Patrick Lugenbiel, Norbert Frey, Derk Frank, Dominik Gramlich, Daniel Finke, Hugo A. Katus, Ann-Kathrin Rahm, Matthias Karck, Arjang Ruhparwar, Pascal Syren, Steffi Sandke, Fadwa A. El Tahry, Bastian Schmack, Teresa Wieder, Lorenz H. Lehmann
Publikováno v:
Basic Research in Cardiology. 116
Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechanisms in the regulation of ion channel expr
Autor:
Patrick, Lugenbiel, Katharina, Govorov, Pascal, Syren, Ann-Kathrin, Rahm, Teresa, Wieder, Maximilian, Wunsch, Nadine, Weiberg, Emili, Manolova, Dominik, Gramlich, Rasmus, Rivinius, Daniel, Finke, Lorenz H, Lehmann, Patrick A, Schweizer, Derk, Frank, Fadwa A, El Tahry, Claus, Bruehl, Tanja, Heimberger, Steffi, Sandke, Tanja, Weis, Patrick, Most, Bastian, Schmack, Arjang, Ruhparwar, Matthias, Karck, Norbert, Frey, Hugo A, Katus, Dierk, Thomas
Publikováno v:
Basic research in cardiology. 116(1)
Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechanisms in the regulation of ion channel expr
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2979 (2008)
Synaptic activity in the central nervous system undergoes rapid state-dependent changes, requiring constant adaptation of the homeostasis between excitation and inhibition. The underlying mechanisms are, however, largely unclear. Chronic changes in n
Externí odkaz:
https://doaj.org/article/99728be828824c53873c9233589625e5
Autor:
Fabrice F Darche, Hugo A. Katus, Claus Bruehl, Dirk Hose, Dierk Thomas, Julian Schröter, Richard Gabriel, Uwe Leimer, Andreas Draguhn, Manfred Schmidt, Patrick A. Schweizer, Günter Germann, Eva Köllensperger, Anja Seckinger, Michael Koenen, Rasmus Rivinius
Publikováno v:
Life Sciences
Aims Cell-based biological pacemakers aim to overcome limitations and side effects of electronic pacemaker devices. We here developed and tested different approaches to achieve nodal-type differentiation using human adipose- and bone marrow-derived m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdebd6ca1210e895800c7f90b355c00
https://www.ncbi.nlm.nih.gov/pubmed/31291594
https://www.ncbi.nlm.nih.gov/pubmed/31291594
Publikováno v:
Neuroscience. 393
Retinal ganglion cells (RGCs), a diverse body of neurons which relay visual signals from the retina to the higher processing regions of the brain, are susceptible to neurodegenerative processes in several diseases affecting the retina. Previous evide