Výsledky vyhledávání - "Claudius Pak"

Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols

Autor: Tanja Zivkovic Semren, Shoaib Majeed, Maria Fatarova, Csaba Laszlo, Claudius Pak, Sandro Steiner, Guillermo Vidal-de-Miguel, Arkadiusz Kuczaj, Anatoly Mazurov, Manuel C. Peitsch, Nikolai V. Ivanov, Julia Hoeng, Philippe A. Guy

Publikováno v: Journal of the American Society for Mass Spectrometry. 33(11)

Inhalation as a route for administering drugs and dietary supplements has garnered significant attention over the past decade. We performed real-time analyses of aerosols using secondary electrospray ionization (SESI) technology interfaced with high-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9ac41fb24c31f3b8f2b5085d373973
https://pubmed.ncbi.nlm.nih.gov/36218284

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Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro

Publikováno v: Archives of Toxicology

Aging and smoking are major risk factors for cardiovascular diseases (CVD). Our in vitro study compared, in the context of aging, the effects of the aerosol of Tobacco Heating System 2.2 (THS; an electrically heated tobacco product) and 3R4F referenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd36e7a5e84bef9b672dee515ef85d8
https://doi.org/10.1007/s00204-021-03123-y

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Real-Time Chemical Characterization of Aerosols by Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry

Autor: Tanja Zivkovic Semren, Shoaib Majeed, Maria Fatarova, Csaba Laszlo, Claudius Pak, Sandro Steiner, Guillermo Vidal, Arkadiusz Kuczaj, Anatoly Mazurov, Joanne Chua, Manuel C. Peitsch, Nikolai V. Ivanov, Julia Hoeng, Philippe A. Guy

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd0cc87ff74ffc343aba3035d28d7023
https://doi.org/10.2139/ssrn.4125879

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Impact of aerosols on liver xenobiotic metabolism: A comparison of two methods of exposure

Autor: David Bovard, Shoaib Majeed, Claudius Pak, Alexandre Beguin, Antonin Sandoz, Stefan Frentzel, Sandra Ferreira, Lucile Pinard, Anita R. Iskandar, Manuel C. Peitsch, Diego Marescotti, Kasper Renggli, Anaïs Barbier, Julia Hoeng

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 79

Assessment of aerosols effects on liver CYP function generally involves aqueous fractions (AF). Although easy and efficient, this method has not been optimized recently or comparatively assessed against other aerosol exposure methods. Here, we compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2a2534b8421e70f9cfced2408dd7f6
https://pubmed.ncbi.nlm.nih.gov/34843886

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Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES)

Autor: Arkadiusz K. Kuczaj, Claudius Pak, Antonin Sandoz, Shoaib Majeed, Julia Hoeng, Pierre Herve, Sandro Steiner

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 67

The dose of inhaled materials delivered to the respiratory tract is to a large extent a function of the kinetics of particle deposition and gas dissolution on or in the airway and lung epithelia, and therefore of the structural and functional propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c44ab45ff78bb0b852a61a9febaa5a
https://pubmed.ncbi.nlm.nih.gov/32512146

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Corrigendum to 'The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product' published in Toxicology in Vitro, Volume 50, August 2018, Pages 95-108

Autor: David Bornand, Manuel C. Peitsch, Karin Baumer, Remi Dulize, Claudius Pak, Stephanie Johne, Elena Scotti, Karsta Luettich, Marco van der Toorn, Emmanuel Guedj, Alain Sewer, Maica Corciulo, Julia Hoeng, Celine Merg, Diego Marescotti, Nikolai V. Ivanov, Florian Martin, Patrice Leroy

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3bc7746106d9f65ae58c110169fdae
https://pubmed.ncbi.nlm.nih.gov/29524472

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Systems toxicology revealed reduced impact of ths 2.2 aerosol relative to 3R4F smoke on aortic smooth muscle cell aging and exacerbation effects in aged cells in vitro

Publikováno v: Atherosclerosis. 315:e272

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e9067ee017763669ceca5e5894cf356
https://doi.org/10.1016/j.atherosclerosis.2020.10.857

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In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells

Autor: Dariusz Peric, Claudius Pak, Stefano Acali, David Bornand, Julia Hoeng, Emmanuel Guedj, Athanasios Kondylis, Nikolai V. Ivanov, Elodie Maluenda, Didier Goedertier, Alexandra Laurent, Ignacio Gonzalez Suarez, Karine Baumer, Remi Dulize, Diego Marescotti, Marco van der Toorn, Manuel C. Peitsch, Carine Poussin, Walter K. Schlage

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 120

Cigarette smoking causes cardiovascular diseases. Heating tobacco instead of burning it reduces the amount of toxic compounds in the aerosol and may exert a reduced impact on health compared with cigarette smoke. Aqueous extract from the aerosol of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e99f1474dd47de099361a9f0e58a7ea
https://pubmed.ncbi.nlm.nih.gov/30026091

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The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product

Autor: Claudius Pak, Karsta Luettich, Karin Baumer, Remi Dulize, Patrice Leroy, David Bornand, Elena Scotti, Julia Hoeng, Diego Marescotti, Stephanie Johne, Maica Corciulo, Alain Sewer, Manuel C. Peitsch, Emmanuel Guedj, Celine Merg, Marco van der Toorn, Nikolai V. Ivanov, Florian Martin

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 50

Cigarette smoking is the leading cause of preventable lung cancer (LC). Reduction of harmful constituents by heating rather than combusting tobacco may have the potential to reduce the risk of LC. We evaluated functional and molecular changes in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63ae36bd7e50dd0652b5f6d322d8cfa
https://pubmed.ncbi.nlm.nih.gov/30686568

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