Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Claudiu C. Gradinaru"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Intrinsically disordered proteins play key roles in regulatory protein interactions, but their detailed structural characterization remains challenging. Here we calculate and compare conformational ensembles for the disordered protein Sic1 from yeast
Externí odkaz:
https://doaj.org/article/d0b02bef31d5493c950fd75b93ab2a8d
Autor:
Dennis D. Fernandes, Chris Neale, Gregory-Neal W. Gomes, Yuchong Li, Aimen Malik, Aditya Pandey, Alexander P. Orazietti, Xudong Wang, Libin Ye, R. Scott Prosser, Claudiu C. Gradinaru
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states w
Externí odkaz:
https://doaj.org/article/1d5a6aaa4ef3450b9bd0c50f9ac512ec
Autor:
Jennifer E. Dawson, Alaji Bah, Zhenfu Zhang, Robert M. Vernon, Hong Lin, P. Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C. Gradinaru, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to
Externí odkaz:
https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
Autor:
Syed Mukhtar Ahmed, Hisayo Nishida-Fukuda, Yuchong Li, W. Hayes McDonald, Claudiu C. Gradinaru, Ian G. Macara
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Exocyst complex tethers vesicles to plasma membranes, but assembly mechanisms remain unclear. Here, the authors use Cas9 gene editing to tag exocyst components in epithelial cells, and find that exocyst subcomplexes are recruited to membranes indepen
Externí odkaz:
https://doaj.org/article/80e44de8f19547999c48c3abdab08f24
Autor:
Syed Mukhtar Ahmed, Hisayo Nishida-Fukuda, Yuchong Li, W. Hayes McDonald, Claudiu C. Gradinaru, Ian G. Macara
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained errors in the author affiliations. Affiliation 2 incorrectly read ‘Department of Biochemistry and Molecular Genetics and Breast Surgery, Ehime University Graduate School of Medicine, 7910295, Japan’
Externí odkaz:
https://doaj.org/article/c17b140fd2fe4c26b01b9df02eb32c3b
Publikováno v:
Biophysical Journal. 121:3175-3187
Single-molecule counting techniques enable a precise determination of the intracellular abundance and stoichiometry of proteins and macromolecular complexes. These details are often challenging to quantitatively assess yet are essential for our under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c36860ed42d49121b60bd7eedd60dd6
https://doi.org/10.1016/j.bpj.2022.07.034
https://doi.org/10.1016/j.bpj.2022.07.034
Autor:
Claudiu C. Gradinaru, Gregory-Neal W. Gomes, Aimen Malik, Alexander P. Orazietti, Aditya Pandey, Dennis D. Fernandes, Chris Neale, Libin Ye, Xudong Wang, Yuchong Li, R. Scott Prosser
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states within a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229f39b61615c1d868bea3ff9c6ae4f5
https://doaj.org/article/1d5a6aaa4ef3450b9bd0c50f9ac512ec
https://doaj.org/article/1d5a6aaa4ef3450b9bd0c50f9ac512ec
Autor:
Pavithra M. Naullage, Mojtaba Haghighatlari, Ashley Namini, João M. C. Teixeira, Jie Li, Oufan Zhang, Claudiu C. Gradinaru, Julie D. Forman-Kay, Teresa Head-Gordon
Publikováno v:
The journal of physical chemistry. B, vol 126, iss 9
J Phys Chem B
J Phys Chem B
Intrinsically disordered proteins and unfolded proteins have fluctuating conformational ensembles that are fundamental to their biological function and impact protein folding, stability and misfolding. Despite the importance of protein dynamics and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3785697e8c61865d87c34d0e3028f6b1
https://escholarship.org/uc/item/5g28b0tt
https://escholarship.org/uc/item/5g28b0tt
Autor:
Spencer Smyth, Zhenfu Zhang, Alaji Bah, Thomas E. Tsangaris, Jennifer Dawson, Julie D. Forman-Kay, Claudiu C. Gradinaru
Intrinsically disordered proteins (IDPs) play critical roles in regulatory protein interactions, but detailed structural/dynamics characterization of their ensembles remain challenging, both in isolation and they form dynamic ‘fuzzy’ complexes. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac5acc0e058cbe35ff61e526c8e8469
https://doi.org/10.1101/2022.01.14.476386
https://doi.org/10.1101/2022.01.14.476386
Publikováno v:
Biophysical Journal. 122:62a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbf079d0db174259defd74ebed0d761
https://doi.org/10.1016/j.bpj.2022.11.544
https://doi.org/10.1016/j.bpj.2022.11.544