Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Claudio Zambaldo"'
Autor:
Jason S. Chen, Benjamin F. Cravatt, Jonathan Iaconelli, Minseob Koh, Michael J. Bollong, Peter G. Schultz, Ekaterina V. Vinogradova, Stormi R Chadwick, Kristine Senkane, Xiaotian Qi, Peng Liu, Arnab Chatterjee, Claudio Zambaldo, Radu M. Suciu, Brittany Sanchez
Publikováno v:
J Am Chem Soc
The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd4de3fdea02c9acf05e1b892583211
https://doi.org/10.1021/jacs.0c02721
https://doi.org/10.1021/jacs.0c02721
Autor:
Sophia Z, Shalhout, Peng-Yu, Yang, Edyta M, Grzelak, Kayla, Nutsch, Sida, Shao, Claudio, Zambaldo, Jonathan, Iaconelli, Lara, Ibrahim, Caroline, Stanton, Stormi R, Chadwick, Emily, Chen, Michael, DeRan, Sijia, Li, Mitchell, Hull, Xu, Wu, Arnab K, Chatterjee, Weijun, Shen, Fernando D, Camargo, Peter G, Schultz, Michael J, Bollong
Publikováno v:
Nature chemical biology. 17(7)
The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::113abd6d43aecc5052478625d0c29143
https://pubmed.ncbi.nlm.nih.gov/33758335
https://pubmed.ncbi.nlm.nih.gov/33758335
Autor:
Claudio Zambaldo, Insha Ahmad, Luke L. Lairson, Raymond E. Moellering, Arnab Chatterjee, Gihoon Lee, Jae Won Chang, John S. Coukos, Peter G. Schultz, Emily N. Chin, Michael J. Bollong, Hwayoung Yun
Publikováno v:
Nature
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926fdff3faef8d15386b23690c872a81
http://europepmc.org/articles/PMC6444936
http://europepmc.org/articles/PMC6444936
Publikováno v:
Bioorganic & Medicinal Chemistry, Vol. 25, No 19 (2017) pp. 5171-5177
Peptide nucleic acids (PNAs) derivatized with functional molecules are increasingly used in diverse biosupramolecular applications. PNAs have proven to be highly tolerant to modifications and different applications benefit from the use of modified PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb414ffb0bb868e5a32e420a939cd5b8
https://doi.org/10.1016/j.bmc.2017.05.064
https://doi.org/10.1016/j.bmc.2017.05.064
Autor:
Yuhan Zhang, Feng Wang, Anzhi Yao, Xiaoxuan Lyu, Sean A. Reed, Xiaozhou Luo, Peng-Yu Yang, Chunhui Huang, Xueyong Zhu, Renhe Liu, Peter G. Schultz, Rongsheng E. Wang, Weimin Xuan, Ian A. Wilson, Mingchao Kang, Claudio Zambaldo, Tao Liu, Guangsen Fu, Hui Guo, Jintang Du
Publikováno v:
Nature chemical biology
Tyrosine phosphorylation is a common protein posttranslational modification, which plays a critical role in signal transduction and the regulation of many cellular processes. Using a pro-peptide strategy to increase cellular uptake of O-phosphotyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dc84c54ebf75d6a7e032304bb4e894
http://europepmc.org/articles/PMC5577365
http://europepmc.org/articles/PMC5577365
Autor:
Aaron D. Pearson, Shan Yu, Reyna Kv Lim, Peter G. Schultz, Sijia Li, Michael J. Bollong, Stephanie A. Kazane, Meredith Weglarz, Travis S. Young, Claudio Zambaldo, Eric Hampton, Timothy M. Wright, Holly Parker, Ashley K. Woods, Jiayin Shen, David T. Rodgers, Danling Wang, Matthew S. Tremblay
Publikováno v:
Molecular Therapy. 24:2078-2089
Phosphodiesterase 4 (PDE4) inhibitors are approved for the treatment of some moderate to severe inflammatory conditions. However, dose-limiting side effects in the central nervous system and gastrointestinal tract, including nausea, emesis, headache,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b6e1939ad52b6eeac97d94bcbf4124
https://doi.org/10.1038/mt.2016.175
https://doi.org/10.1038/mt.2016.175
Publikováno v:
Organic letters. 21(23)
Herein we provide a generalizable method for the cost-effective synthesis of thousands of building blocks (BBs) employing DNA-incompatible chemistries. The ability to produce large numbers of crude products via solid-phase synthesis has existed for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc51ba47414e8dd5882937f009510e77
https://pubmed.ncbi.nlm.nih.gov/31747291
https://pubmed.ncbi.nlm.nih.gov/31747291
Autor:
Claudio Zambaldo, Yuhan Zhang, Sean A. Reed, Travis S. Young, Chen Wang, Peng-Yu Yang, Tao Liu, Weimin Xuan, Tsotne Javahishvili, Xiaozhou Luo, Rongsheng E. Wang, Peter G. Schultz
Publikováno v:
Proceedings of the National Academy of Sciences. 113:3615-3620
Thiopeptides are a subclass of ribosomally synthesized and posttranslationally modified peptides (RiPPs) with complex molecular architectures and an array of biological activities, including potent antimicrobial activity. Here we report the generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d737256684bcb517214e7986fc3d8e
https://doi.org/10.1073/pnas.1602733113
https://doi.org/10.1073/pnas.1602733113
Autor:
Mihai Ciobanu, Jean-Pierre Daguer, Pierre Morieux, Claudio Zambaldo, Nicolas Winssinger, Sofia Barluenga, Heraklidia A. Ioannidou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 3 (2016) pp. 1080-1085
Bioorganic {&} Medicinal Chemistry Letters
Bioorganic {&} Medicinal Chemistry Letters
DNA display of PNA-encoded libraries was used to pair fragments containing different phosphotyrosine surrogates with diverse triazoles. Microarray-based screening of the combinatorially paired fragment sets (62,500 combinations) against a prototypica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733c10ab98821bf0d29e3719fc59196d
https://doi.org/10.1016/j.bmcl.2015.11.102
https://doi.org/10.1016/j.bmcl.2015.11.102
Publikováno v:
Medchemcomm
MedChemComm, Vol. 7, No 7 (2016) pp. 1340-1351
MedChemComm, Vol. 7, No 7 (2016) pp. 1340-1351
DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically designed with synthon filtered out for reactive functionalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37e46479809377ec445e1393a04bfd5