Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Claudio P Albuquerque"'
Autor:
Raymond T Suhandynata, Yun Quan, Yusheng Yang, Wei-Tsung Yuan, Claudio P Albuquerque, Huilin Zhou
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008477 (2019)
The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. H
Externí odkaz:
https://doaj.org/article/b4d8cdfd98514d7cafa4e1e71631908b
Autor:
Claudio P Albuquerque, Guoliang Wang, Nancy S Lee, Richard D Kolodner, Christopher D Putnam, Huilin Zhou
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006302 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1003670.].
Externí odkaz:
https://doaj.org/article/f8810fee588643df8f5476fa2ef80986
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143810 (2015)
A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzy
Externí odkaz:
https://doaj.org/article/e531dbee0d144b53b0dd22042ba1677a
Autor:
Claudio P Albuquerque, Guoliang Wang, Nancy S Lee, Richard D Kolodner, Christopher D Putnam, Huilin Zhou
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003670 (2013)
Suppression of duplication-mediated gross chromosomal rearrangements (GCRs) is essential to maintain genome integrity in eukaryotes. Here we report that SUMO ligase Mms21 has a strong role in suppressing GCRs in Saccharomyces cerevisiae, while Siz1 a
Externí odkaz:
https://doaj.org/article/9967c9ded9da46909d1f938f22715996
Autor:
Claudio P. Albuquerque, Andrew K. Shiau, Hui Huang, Kai Ge, Kevin D. Corbett, Huilin Zhou, Andrea Local, Namit Singh, Wei Wang, Ah Young Lee, Dong Wang, Chaochen Wang, Judy E. Hsia, Bing Ren
Publikováno v:
Nature Genetics. 50:73-82
Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21aa0bfa324b504c3b8591f78e3c8d53
https://doi.org/10.1038/s41588-017-0015-6
https://doi.org/10.1038/s41588-017-0015-6
Autor:
Huilin Zhou, John DeGroot, Erik P. Sulman, Frank B. Furnari, Andrew K. Shiau, Webster K. Cavenee, Ciro Zanca, Shunichiro Miki, Timothy C. Gahman, Laura Orellana, Rachel Reed, Suely Kazue Nagahashi Marie, Clark C. Chen, Jianhui Ma, Thais F. Galatro, Richard D. Kolodner, Jorge A. Benitez, Claudio P. Albuquerque, Jie Li, Tomoyuki Koga, Erik Lindahl, Nissi Varki, Antonia D. Boyer, Tim R. Fenton
Publikováno v:
Cancer Cell
Cancer cell, vol 35, iss 3
Cancer cell, vol 35, iss 3
Ionizing radiation (IR) and chemotherapy are standard of care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7401ad416b889b96c08547fea8cb25
https://europepmc.org/articles/PMC6946119/
https://europepmc.org/articles/PMC6946119/
Autor:
Claudio P. Albuquerque, Raymond T. Suhandynata, Wei-Tsung Yuan, Yusheng Yang, Yun Quan, Huilin Zhou
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008477 (2019)
PLoS Genetics
PLoS Genetics
The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb55987fa728d64c5702a509aea9b84
https://doaj.org/article/b4d8cdfd98514d7cafa4e1e71631908b
https://doaj.org/article/b4d8cdfd98514d7cafa4e1e71631908b
Publikováno v:
Journal of Biological Chemistry. 291:8825-8835
Small ubiquitin-like modifier (SUMO) E3 ligases are known to have a major role in preventing gross chromosomal rearrangements (GCRs); however, relatively little is known about the role of SUMO isopeptidases in genome maintenance and their role in con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5239eb09e4d9dd6744f472b505cd1942
https://doi.org/10.1074/jbc.m116.716399
https://doi.org/10.1074/jbc.m116.716399
Autor:
Christopher R. Carlson, Claudio P. Albuquerque, Huilin Zhou, Wei-Tsuang Yuan, Raymond T. Suhandynata
Publikováno v:
The Journal of biological chemistry, vol 293, iss 31
Ulp1 and Ulp2, in the yeast Saccharomyces cerevisiae, are the founding members of deSUMOylating enzymes. These enzymes remove s mall u biquitin-like mo difier (SUMO) from proteins and are conserved in all eukaryotes. Previous studies have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db95e6ca1da57788fc85a820a5dfbee5
https://europepmc.org/articles/PMC6078457/
https://europepmc.org/articles/PMC6078457/
Autor:
Huilin Zhou, Christopher R. Carlson, Kevin D. Corbett, Claudio P. Albuquerque, Jason Liang, Namit Singh
Publikováno v:
Genesdevelopment. 31(8)
Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but still poorly understood regulatory roles in eukaryotic cells, including as a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbLs). Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a408e896c8a941c83c793f9481df3e65
https://pubmed.ncbi.nlm.nih.gov/28512234
https://pubmed.ncbi.nlm.nih.gov/28512234