Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Claudio Mussolino"'
Autor:
Carolin Gerke, Liane Bauersfeld, Ivo Schirmeister, Chiara Noemi-Marie Mireisz, Valerie Oberhardt, Lea Mery, Di Wu, Christopher Sebastian Jürges, Robbert M Spaapen, Claudio Mussolino, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Lars Dölken, Wolfgang Paster, Florian Erhard, Maike Hofmann, Andreas Schlosser, Hartmut Hengel, Frank Momburg, Anne Halenius
Publikováno v:
eLife, Vol 13 (2024)
Human leucocyte antigen class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV) disease. To create opportunities for viral spread, several HCMV-encoded immunoevasins employ dive
Externí odkaz:
https://doaj.org/article/c867fd290b5f4af9870c2dc3f63a87b4
Autor:
Maryam Taghdiri, Claudio Mussolino
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7333 (2024)
Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled precise genome editing with unprecedented accuracy and efficiency, paving
Externí odkaz:
https://doaj.org/article/c63857ddeb6a4ef68db91a6a2ffb9a0f
Autor:
Ruba Hammad, Jamal Alzubi, Manuel Rhiel, Kay O. Chmielewski, Laura Mosti, Julia Rositzka, Marcel Heugel, Jan Lawrenz, Valentina Pennucci, Birgitta Gläser, Judith Fischer, Axel Schambach, Thomas Moritz, Nico Lachmann, Tatjana I. Cornu, Claudio Mussolino, Richard Schäfer, Toni Cathomen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 985 (2024)
The CRISPR-Cas12a platform has attracted interest in the genome editing community because the prototypical Acidaminococcus Cas12a generates a staggered DNA double-strand break upon binding to an AT-rich protospacer-adjacent motif (PAM, 5′-TTTV). Th
Externí odkaz:
https://doaj.org/article/119eb899f651407ca1f5944ad9f5c6cc
Autor:
Nikoletta Y. Papaioannou, Petros Patsali, Basma Naiisseh, Panayiota L. Papasavva, Lola Koniali, Ryo Kurita, Yukio Nakamura, Soteroula Christou, Maria Sitarou, Claudio Mussolino, Toni Cathomen, Marina Kleanthous, Carsten W. Lederer
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Introduction: Genome editing tools, such as CRISPR/Cas, TALE nucleases and, more recently, double-strand-break-independent editors, have been successfully used for gene therapy and reverse genetics. Among various challenges in the field, tolerable an
Externí odkaz:
https://doaj.org/article/0fbfbdfb3fde4f0eb2824e45f9241f24
Autor:
Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immu
Externí odkaz:
https://doaj.org/article/e1802e6cee45487398ad67ff6d224f5a
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://doaj.org/article/e8aa757ae0ec4109904f3108d8338f68
Autor:
Claudio Mussolino, John Strouboulis
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Tissue oxygenation throughout life depends on the activity of hemoglobin (Hb) one of the hemeproteins that binds oxygen in the lungs and secures its delivery throughout the body. Hb is composed of four monomers encoded by eight different genes the ex
Externí odkaz:
https://doaj.org/article/e0df94cce81c4394b15504b38433a03c
Autor:
Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely, Patrick Arbuthnot
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Chronic infection with hepatitis B virus (HBV) is a serious global health problem. Persistence of the virus occurs as a result of stability of the replication intermediate comprising covalently closed circular DNA (cccDNA). Develo
Externí odkaz:
https://doaj.org/article/43d37d072faf498288f79ace82905387
Autor:
Petros Patsali, Giandomenico Turchiano, Panayiota Papasavva, Marianna Romito, Constantinos C. Loucari, Coralea Stephanou, Soteroulla Christou, Maria Sitarou, Claudio Mussolino, Tatjana I. Cornu, Michael N. Antoniou, Carsten W. Lederer, Toni Cathomen, Marina Kleanthous
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Externí odkaz:
https://doaj.org/article/d0e06e164c7d47edb92e9f732efff970
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 112-123 (2017)
Epidermolysis bullosa simplex (EBS) is a blistering skin disease caused by dominant-negative mutations in either KRT5 or KRT14, resulting in impairment of keratin filament structure and epidermal fragility. Currently, nearly 200 mutations distributed
Externí odkaz:
https://doaj.org/article/2ff5490c1ff54dcd94602b2ca0e7101f