Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Claudio M. Sergio"'
Autor:
Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal
Externí odkaz:
https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e
Autor:
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92
Autor:
Investigators k, Kristine J. Fernandez, Serra, Paul Waring, Elgene Lim, C.E. Caldon, Danielle Ferraro, Dariush Etemadmoghadam, Wilkinson A, Diar Aziz, Sarah Alexandrou, Claudio M Sergio, Christine S. L. Lee, Aliza Yong, David D.L. Bowtell, Alba Llop-Guevara, Neil Portman
Basal-like breast cancers (BLBC) are aggressive breast cancers that respond poorly to targeted therapies and chemotherapies. In order to define therapeutically targetable subsets of BLBC we examined two markers: cyclin E1 and BRCA1 loss. In high grad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fbfc75badafe8d8f196bcd847b1e34
Autor:
Wendy Wing Yee Au, Samantha R. Oakes, Belinda Whittle, Jesse Donovan, Matthew J. Naylor, Christopher J. Ormandy, Zoya Kikhtyak, David Gallego-Ortega, Andrew M. K. Law, Stephanie L. Allerdice, Adelaide I. J. Young, Christopher C. Goodnow, Simon Junankar, Anita von Korff, Claudio M Sergio, Edward M. Bertram, Moira K O'Bryan, Lesley Castillo, Catherine L. Piggin, Daniel L. Roden, Prudence M Stanford, Alexei Korennykh
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Autor:
Andrew Burgess, Samuel Rogers, Catherine E Caldon, Marcel E. Dinger, Elizabeth A. Musgrove, Claudio M Sergio, Christine S. L. Lee, Brian S. Gloss
Publikováno v:
Cell Division
Background The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesis, splicing, centrosome duplic
Autor:
Rachael A. McCloy, Fatima Valdes-Mora, Andrew V. Biankin, David Gallego-Ortega, Susan J. Clark, Robert Ian Nicholson, Julia Margaret Wendy Gee, Mark J. Cowley, Claudio M Sergio, Cristin G. Print, C. E. Caldon, Christopher J. Ormandy, Elizabeth A. Musgrove, Andrew Stone
Publikováno v:
Molecular cancer therapeutics. 12(9)
Overexpression of the antiapoptotic factor BCL-2 is a frequent feature of malignant disease and is commonly associated with poor prognosis and resistance to conventional chemotherapy. In breast cancer, however, high BCL-2 expression is associated wit
Autor:
Elizabeth A. Musgrove, Eileen M. Rogan, Claudio M. Sergio, Robert L. Sutherland, Colin K. W. Watts, Jason S. Carroll, Owen W. J. Prall
Publikováno v:
Steroid Hormones and Cell Cycle Regulation ISBN: 9781461353270
The role of estrogen in the growth of breast cancer was recognised over a century ago when it was shown that ovariectomy in premenopausal women with breast cancer resulted in tumor regression (Beatson 1896). Subsequent research showed that estrogen e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b72371613003bdab8360ce639f30a4
https://doi.org/10.1007/978-1-4615-0965-3_4
https://doi.org/10.1007/978-1-4615-0965-3_4
Autor:
Siobhan E. Guilfoyle, John A. Morris, Scott E. Youlten, Graham R. Williams, Michael R.G. Dack, Elena J. Ghirardello, Amelia R. McGlade, Davide Komla-Ebri, John P. Kemp, Paul A. Baldock, David J. Adams, David M. Evans, J. H. Duncan Bassett, John G. Logan, Victoria D. Leitch, Fernando Rivadeneira, Eleftheria Zeggini, Michelle M. McDonald, Ryan C. Chai, Tri Giang Phan, Nenad Bartonicek, Melita Irving, Konstantinos Hatzikotoulas, Christopher J. Lelliott, Matt Jansson, Robert Brink, James T. Smith, Peter I. Croucher, Ana Beleza-Meireles, Claudio M Sergio, Sindhu T. Mohanty, J. Brent Richards, Alexander P. Corr, Natalie C. Butterfield, Emma L. Duncan, John A. Eisman, Julian M.W. Quinn
Publikováno v:
BioRxiv
Nat. Commun. 12:2444 (2021)
Nature Communications
Nature Communications, 12(1):2444. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
bioRxiv
Nat. Commun. 12:2444 (2021)
Nature Communications
Nature Communications, 12(1):2444. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
bioRxiv
Osteocytes are master regulators of the skeleton. We mapped the transcriptome of osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cellular-network. We define an os