Výsledky vyhledávání - "Claudio M. Lezama-Davila"

Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana

Autor: Abhay R. Satoskar, A. Douglas Kinghorn, MY Pech-Dzib, Cesar Terrazas, Angélica P. Isaac-Márquez, Narasimham L. Parinandi, Steve Oghumu, Joseph Barbi, Edward Calomeni, Li Pan, Claudio M. Lezama-Davila, Ricardo Isaac-Márquez

Publikováno v: Phytotherapy Research. 28:909-916

Cutaneous leishmaniasis (CL) manifests as localized skin lesions, which lead to significant tissue destruction and disfigurement. In the Yucatan Peninsula, Mayan traditional healers use Pentalinon andrieuxii Muell.-Arg. (Apocynaceae) roots for the to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::127f81e627b1931a8d9b6cb5c51b7415
https://doi.org/10.1002/ptr.5079

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In vitroLeishmanicidal and Cytotoxic Activities of the Glycoalkaloids fromSolanum lycocarpum(Solanaceae) Fruits

Autor: Angelica Patricia Isaac-Marquez, Sérgio de Albuquerque, Claudio M. Lezama-Davila, Mariana Rosa da Silva, Kelly Cristina Rodrigues, Christian Collins Kuehn, Luiz Gustavo Rodrigues Oliveira, Renata Fabiane Jorge Tiossi, Jairo Kenupp Bastos, Mariza Abreu Miranda, James D. McChesney

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Leishmaniasis is an infection caused by a protozoan parasite of the genus Leishmania and is the second most prevalent parasitic protozoal disease after malaria in the world. We report the in vitro leishmanicidal activity on promastigote forms of Leis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae805c0fb687505ff6f1d652f2f18750
https://doi.org/10.1002/cbdv.201200063

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Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse

Autor: Sanjay Varikuti, Caroline C. Whitacre, Arlene H. Sharpe, Ran Dong, Steve Oghumu, Todd Shawler, Abhay R. Satoskar, Brian M. M. Ahmer, Cesar Terrazas, Claudio M. Lezama-Davila, Sanjay Rajagopalan, Thomas Kampfrath, Richard M. Locksley

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 190, iss 5

CXCR3, expressed mainly on activated T and NK cells, is implicated in a host of immunological conditions and can contribute either to disease resolution or pathology. We report the generation and characterization of a novel CXCR3 internal ribosome en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89449dd75bf3013403c4ded5d0cd0bc9
https://doi.org/10.4049/jimmunol.1201170

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Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii

Autor: Li Pan, Angélica P. Isaac-Márquez, James R. Fuchs, Edward Calomeni, Abhay R. Satoskar, A. Douglas Kinghorn, Claudio M. Lezama-Davila

Publikováno v: Phytochemistry. 82:128-135

A new cholesterol derivative, pentalinonsterol (cholest-4,20,24-trien-3-one, 1), and a new polyoxygenated pregnane sterol glycoside, pentalinonside (2), together with 18 known compounds, including 14 sterols (3-16), three coumarins (17-19), and a tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6028e65b6fef3d0d6f7d0c5142335725
https://doi.org/10.1016/j.phytochem.2012.06.012

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Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis

Autor: Sanjay Varikuti, Stephanie Seveau, Steve Oghumu, Caroline C. Whitacre, Hannah E. Cummings, Anasuya Sarkar, Mark D. Wewers, Patrick K. Reville, Danuta Radzioch, Abhay R. Satoskar, Nicholas Zorko, Thomas Rückle, Joseph Barbi, Claudio M. Lezama-Davila, Tracy L. Keiser, Bao Lu, Christian Rommel

Publikováno v: Proceedings of the National Academy of Sciences. 109:1251-1256

Obligate intracellular pathogens such as Leishmania specifically target host phagocytes for survival and replication. Phosphoinositide 3-kinase γ (PI3Kγ), a member of the class I PI3Ks that is highly expressed by leukocytes, controls cell migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e344cedb22634cc44d4b7f33fc47b199
https://doi.org/10.1073/pnas.1110339109

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Leishmanicidal Activity of Two Naphthoquinones against Leishmania donovani

Autor: Govind J. Kapadia, Steve Oghumu, Abhay R. Satoskar, Claudio M. Lezama-Davila, Stephen M. Beverley, Katherine Owens, Angélica P. Isaac-Márquez

Publikováno v: Biological and Pharmaceutical Bulletin. 35:1761-1764

Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c96fb80388b53f04a220b4cd9a711ddd
https://doi.org/10.1248/bpb.b12-00419

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Sex Hormones and Modulation of Immunity against Leishmaniasis

Autor: James Alexander, Claudio M. Lezama-Davila, Abhay R. Satoskar, Heidi M. Snider

Publikováno v: Neuroimmunomodulation. 16:106-113

Sex-associated hormones such as estradiol, testosterone and progesterone have all been shown to modulate immune responses, which can result in differential disease outcomes between males and females, as well as between pregnant and nonpregnant female

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea34c7781ad486d1e06bf5d496bd0ce6
https://doi.org/10.1159/000180265

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A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

Autor: J de Carvalho da Costa, James D. McChesney, Renata Fabiane Jorge Tiossi, Mariza Abreu Miranda, Maria Vitória Lopes Badra Bentley, Claudio M. Lezama-Davila, S. E. Gaitan-Puch, Angélica P. Isaac-Márquez, Jairo Kenupp Bastos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Little has been done during the past 100 years to develop new antileishmanial drugs. Most infected individuals live in poor countries and have a low cash income to be attractive targets to pharmaceutical corporations. Two heterosidic steroids, solama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a266d054c4a9ac1e920e3b51a0b413
https://pubmed.ncbi.nlm.nih.gov/26883711

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Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice

Autor: Abhay R. Satoskar, Anjali A. Satoskar, Tracy L. Keiser, Lucia E. Rosas, Jennifer Kaczmarek, Joseph Barbi, Claudio M. Lezama-Davila, Alecia N. Septer

Publikováno v: International Immunology. 17:1347-1357

The experimental model of high-dose Leishmania mexicana infection is used frequently to study molecular mechanisms regulating Th2 response since most inbred mice regardless of their genetic background display Th2 cytokine-dependent susceptibility to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ac9b8280f154734978d050858cf909
https://doi.org/10.1093/intimm/dxh313

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